Granulocyte colony stimulating factor receptor

R. Stoffel, S. Ziegler, N. Ghilardi, B. Ledermann, F. J. de Suvage, and R. C. Skoda, Permissive role of thrombopoeitin and granulocyte colony-stimulating factor receptors in hematopoietic cell... 

Fig. 11.2. Domain structure of cytokine receptors. Schematic representation of the domain structure of selected cytokine receptors. WS motif conserved WSXWS sequence (W tryptophan S serine X non-conserved amino add) IL interleukin EpoR receptor for erythropoietin GHR growth hormone receptor LIF-R leukemia inhibitory factor receptor G-CSFR granulocyte colony stimulating factor receptor IFNR interferon receptor TNFR tumor necrosis factor receptor NGFR nerve growth factor receptor Fas, CD40 transmembrane receptors of lymphocytes.

Avalos B. Molecular analysis of the granulocyte colony-stimulating factor receptor. Blood 1996 88 761-777. 

Layton, J. E., Hall, N. E., Connell, F., Venhorst, J., and Treudein, H. R. (2001). Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor./. Biol. Chem. 276, 36779-36787. 

Tidow N, Pilz C, Teichmann B, Muller-Brechlin A, Germeshausen M, Kasper B, Rauprich P, Sykora KW, Welte K. Clinical relevance of point mutations in the cytoplasmic domain of the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Blood 1997 89(7) 2369-75. 

Fukunaga, R., Ishizaka-Ikeda, E., Pan, C.-X., Seto, Y. and Nagata, S. (1991) Functional domains of the granulocyte colony- stimulating factor receptor. EMBO J. 10 2855-2865. 

Hortner M, Nielsch U, Mayr LM, Johnston JA, Heinrich PC, Haan S Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J Immunol 2002 169 1219-1227. 

Takahashi T, Tanaka M, Ogasawara J, Suda T, Murakami H, Nagata S. Swapping between Fas and granulocyte colony-stimulating factor receptor. J Biol Chem. 1996 271 17555-60. 

Lloyd AR, Biragyn A, Johnston JA, et al. Granulocyte-colony stimulating factor and lipopolysaccharide regulate the expression of interleukin 8 receptors on polymorphonuclear leukocytes. J Biol Chem 1995 270 28188-28192. 

Demetri, G. D., Griffin, J. D. (1991). Granulocyte colony-stimulating factor and its receptor. Blood 78,2791-808. 

Raines, M. A., Liu, L. D., Quan, S. G., Joe, V., DiPersio, J. F., Golde, D. W. (1991). Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor. Proc. Natl. Acad. Sci. USA 88, 8203-7. 

Zifovudine (AZT) treatment suppresses granulocyte-monocyte colony stimulating factor receptor type alpha (GM-CSFRa) gene expression in murine bone marrow cells. Lfe Sciences, 71, 967-978. 

Granulocyte colony stimulating factor, G-CSF 24 kD 150 kD, G-CSF-R, receptor with associated tyrosine kinase... 

Sashida G, Takaku XI, Honda S et al. Granulocyte colony-stimulating factor (G-CSF) could enhance Fcgamma receptor expression in neutrophils of patients with B-cell lymphoma treated with rituximab. Leuk Lymphoma 2005 46 789-791. 

Terashi K, Oka M, Ohdo S, et al. Close association between clearance of recombinant human granulocyte colony-stimulating factor (G-CSF) and G-CSF receptor on neutrophils in cancer patients. Antimicrob. Agents Chemother. 1999 43 21-24. 

Kotto-Kome AC, FoxSE, LuW,Yang B-B, Christensen RD, Calhoun DA. Evidence that the granulocyte colony-stimulating factor (G-CSF) receptor plays a role in the pharmacokinetics of G-CSF and PegG-CSFusing a G-CSF-R KO model. Pharm. Res. 2004 50 55-58. 

Inhorn, R. C., Carlesso, N., Durstin, M., Frank, D. A., and Griffin, J. D., Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750. Proc. Natl. Acad. Sci. USA 92, 8665-8669 (1995). 

Terashi, K., Oka, M., Ohdo, S., Furukubo, T., Ikeda, C., Fukuda, M., Soda, H., Higuchi, S., and Kohno, S., Close association between clearance of recombinant human granulocyte colony-stimulating factor (G-CSF) and G-CSF receptor on neutrophils in cancer patients, Antimicrobial Agents and Chemotherapy, Vol. 43, No. 1, 1999, pp. 21-24. 

Several cytokine receptors are present in prostate tumors and in prostate cancer cell lines. These include the granulocyte-macrophage colony-stimulating factor receptors (GM-CSF-R) and macrophage colony-stimulating factor receptor (M-CSF-R) (R7, RIO, S4). The presence of interleukin receptors in the prostate tumor which bind interleukins such as IL-2, IL-3, and IL-6 may play a role in hormone-dependent as well as in hormone-refractory prostate cancer tumors (Cl3, R6). However, the importance of these receptors needs to be illuminated. 

R7. Rivas, C. I., Vera, J. C., Delgrado-Lopez, F., Heany, M. L., Guaiquil, V. H., etal., Expression of granulocyte-macrophage colony-stimulating factor receptors in human prostate cancer. Blood 91, 1037-1043 (1998). 

The cytokine subfamily 1 includes erythropoietin (EPO) (that increases red blood cell production and has accordingly been involved in sports drug abuse), granulocyte colony stimulating factor (G-GSF) (that stimulates leucocyte differentiation), GH (used clinically for growth impairment due to GH deficiency), prolactin (PRL) (that promotes milk production), IL-4 and IL-7. The members of this family act via homodimeric receptors. The leucocyte-derived cytokines of this group variously modulate haematopoiesis and immune responses. 

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