Haematopoietic stem cell transplantation

Tabbara, I. A., Ghazal, C.D., and Ghazal, H.H. 1996. The clinical applications of granulocyte-colony-stimulating factor in haematopoietic stem cell transplantation a review. Anticancer Research 16(6B), 3901-3905. 

In accordance with the conference s main topics, the book is divided into five chapters - Haematopoietic stem cells and haematopoiesis , Biology of non-haematopoietic stem cells , Stem cells and malignancy , Cell processing expansion and genetic modification and Clinical haematopoietic stem cell transplantation . 

The final chapter comprises two reports on clinical haematopoietic stem cell transplantation (HSCT). Viktor Khomenko shares the experience of the Kiev center for stem cell transplantation. The final article in this book by Axel Zander and colleagues summarises data with the use of Antithymocyte globuline (ATG) in (HLA-mismatched) allogeneic transplantation, an approach which was promoted in the Hamburg Clinic for HSCT. 

Viens P, Penault-Llorca F, Jacquemier J, et al. High-dose chemotherapy and haematopoietic stem cell transplantation for inflammatory breast cancer pathologic response and outcome. Bone Marrow Transplant 1998 21 249-254. 

Therapy, when replacement of the marrow by allogeneic haematopoietic stem cell transplantation is not possible, comprises 500 mg of methylpred-nisolone by 8 hour intravenous infusion repeated for five consecutive days. Concurrently 15 mg/kg of antilymphocyte or antithymocyte globulin is given... 

Locatelli F, Stefano PD New insights into haematopoietic stem cell transplantation for patients with haemoglobinopathies. Br J Haematol 125 3-11,2004. 

Bind RK, Cohen BA, Russell E, Spero K, Joshi A, Oyama Y, Karpus WJ, Fuo K, Jovauic B, Traynor A, Karth K, Stefaski D, Bums WH (2003a) Haematopoietic stem cell transplantation for progressive multiple sclerosis failure of intense immune suppression to prevent disease progiession m patients with high disability scores. Blood 102 2373-2378. 

Burt RK, Marmont A, Arnold R, Heipi F, Firestein GS, Carrier E, Hahn B, Barr W, Oyama Y, Snowden J, Kalunian K, Traynor A (2003b) Development of a phase III trial of haematopoietic stem cell transplantation for systemic lupus erythmatosis. Bone Marrow Transplant Aug 23 (Suppl 1) S49-S51. 

Healey KM, Pavletic SZ, Al-Omaishi J, Leuschen MP, Pirrucello SJ, Eilipi ML, Enke C, Ursick MM, Hahn E, Bowen JD, Nash RA (2004) Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. Mult Seer 10 284-289. 

Tyndall A, Saccradi R (2005) Haematopoietic stem cell transplantation in the treatment of severe autoimmune disease Results from phase I/II studies, prospective randomized trials and future directions. Chn Exp Immunol l(l) l-9. 

Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation. Mult Scler 10 284-289. 

Donnelly, J.P. Mouton, J.W. Blijlevens, N.M.A. Smiets, A. Verweij, P.E. Depauw, B.E. Pharmacokinetics of a 14 day course of itraconazole nanocrystals given intravenously to allogenic haematopoietic stem cell transplant (HSCT) recipients. Abstr. Intersci. Conf Antimicrob. Agents Che-mother. 2001, 41, 5. 

Bracket C, Azzi N, Demulder A, et al. Hydroxyurea treatment for sickle cell disease Impact on haematopoietic stem cell transplantation s outcome. Bone Marrow Transplant 2004 33 779-803. 

Antabli BA, Bross P, Siegel RS, et al. Empirical antimicrobial therapy of febrile neutropenic patients undergoing haematopoietic stem cell transplantation. Int J Antimicrob Agents 1999 13 127-130. 

Kolve H, Ahlke E, Fegeler W, Ritter J, Jurgens H, GroU AH. Safety, tolerance and outcome of treatment with hposomal amphotericin B in paediatric patients with cancer or undergoing haematopoietic stem cell transplantation. J Antimicrob Chemother 2009 64 383-7. 

Vonk MC, Marjanovic Z, van den Hoogen FH, et al. Long-term foUow-up results after autologous haematopoietic stem cell transplantation for severe systemic sclerosis. Ann Rheum Dis 2008 67 98-104. 

A retrospective study reports the efficacy and safety of leflunomide for treatment of BK virus-associated hemorrhagic cystitis in allogeneic haematopoietic stem cell transplantation recipients (n=14). Three days of oral lOOmg/day leflunomide as loading doses followed by maintenance doses of 20mg/day resulted in complete remission in seven patients, six patients achieved partial remission and two patients had a reduction in urinary BKV-DNA load after leflunomide treatment (>l-log BKV-DNA load reduction). One patient discontinued leflunomide therapy because of GI symptoms and 2 case developed neutropenia. Al ough the role... 

Patients (n = 23) who had undergone allogeneic haematopoietic stem cell transplantation were tested for efficacy and side effects resulting from deferasirox treatment due to hyperferritinemia [25 ]. The most common side effect was nausea and vomiting (n=3). 

Serio B, RosamUio R, Giudice V, Pepe S, Zeppa P, Esposiito S, et al. Low-dose valgancyclovir as cytomegalovirus reactivation prophylaxis in allogeneic haematopoietic stem cell transplantation. Infez Med 2012 20(Suppl. 2) 26-34. 

The safety and immunogenicity of the heat-treated zoster vaccine was assessed in a randomised, double-blind, placebo-controlled, multicenter study in a diverse population of immunocompromised adults (with solid tumour malignancy (STM), haematological malignancy (HM), HIV, or recipients of autologous haematopoietic stem-cell transplant (HCT) or allogeneic HCT). Importantly, this study showed that in all groups the heat-treated zoster vaccine... 

In a study of haematopoietic stem cell transplant for chronic granulomatous disease patients who were transplanted with either matched related donor (n=4) or matched unrelated donor (n=7), four patients experienced grade I skin acute graft-versus-host disease that responded to topical treatment and all were alive (between 1 and 8 years) after transplant [169 ]. 

Immunologic In a case series of 179 paediatric allogeneic haematopoietic stem cell transplants, they had a 48% incidence of grade O-I and 52% incidence of grade II-IV acute graft-versus-host disease [175 ]. Only malignant... 

The drug interaction between oral voriconazole 400 mg and a stable dose of oral ciclosporin A (CsA) was compared in a prospective trial of 20 adult recipients of haematopoietic stem cell transplantation (HSCT). With concurrent therapy, the median concentration/dose (C/D) ratio of CsA increased significantly from 64.1 to 114.3(ng/mL)/(mg/kg) (p<0.01) [4 ]. 

Clinical trial A phase II clinical trial found that leuprolide did not have efficacy in reducing premature ovarian failure in women undergoing haematopoietic stem cell transplantation Nine of the 59 patients declined the second dose of leuprolide due to intolerable menopausal side effects (hot flushing, atrophic vaginitis and mood swings). No permanent or grade 4 side effects were observed in any of the participants. 

Rauh, M., Stachel, D., Kuhlen, M., Groschl, M., Holter, W. and Rascher, W., Quantification of busulfan in saliva and plasma in haematopoietic stem cell transplantation in children validation of liquid chromatography tandem mass spectrometry method. Clin. Pharmacokinet.,... 

Evans A, Steward CG, Lyburn ID, Grier DJ (2003) Imaging in haematopoietic stem cell transplantation. Clin Radiol 58 201-214... 

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