Granulocyte colony-stimulating factor pegylated

PEGylated human granulocyte colony stimulating factor PEGylated human interferon alpha 2a... [Pg.706]

Neutropenia associated with interferon or pegylated interferon therapy is defined as an absolute neutrophil count (ANC) of less than 1000 cells/mm3 in rare cases, an ANC less than 500 cells/mm3 maybe observed. The neutropenia is more common and in some cases more severe with pegylated interferon than with unmodified interferon. Neutropenia usually occurs within the first 2 weeks after initiating either formulation of interferon, with the WBC count stabilizing by week four or six. The neutropenia is reversible upon discontinuing therapy. Granulocyte colony-stimulating factor has been used as an adjunctive therapy for interferon-induced neutropenia in hepatitis patients.44... [Pg.356]

Rosendahl, Mary S. Doherty, Daniel H. Smith, Darin J. Bendele, Alison M. Cox, George N. Site-specific protein PEGylation Application to cysteine analogs of recombinant human granulocyte colony-stimulating factor, BioProcess International (2005), 3(4), 52-56, 58-60, 62. [Pg.400]

PEG-G-CSF PEGylated recombinant methionyl human granulocyte colony stimulating factor... [Pg.13]

C. Maullu, D. Raimondo, F. Caboi, A. Giorgetti, M. Sergi, M. Valentin , G. Tonon, A. Tramontano, Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor. FEES /., 276 (22) 6741-6750, 2009. [Pg.96]

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