Expression of Human

Schiller, P., Amin, J., Ananthan, J., Brown, M.E., Scott, W.A., Voellmy, R. (1988). Cis acting elements involved in the regulated expression of human hsp70 gene. J. Mol. Biol. 203, 97-105. 

Lores P, Boucher V, Mackay C, Pla M, Von Boehmer H, Jami J, Barre-Sinoussi E, Weill JC (1992) Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection. AIDS Res Hum Retroviruses 8 2063-2071 Maddon PJ, Dalgleish AG, McDougal JS, Clapham PR, Weiss RA, Axel R (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47 333-348... 

Malherbe P, C Kohler, M Da Prada, G Lang, V Kiefer, R Schwarcz, H-W Lahm, AM Cesura (1994) Molecular cloning and functional expression of human 3-hydroxyanthranilic-acid dioxygenase. J Biol Chem 269 13792-13979. 

Ceballos-Picot, I., Nicole, A., Briand, P., Grimber, G., Delacourte, A., Defossez, A., Javoy-Agid, F., Lafon, M., Blouin, J.L. and Sinet, P.M. (1991). Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice animal model of gene dosage effects in Down s syndrome. Brain Res, 552, 198-214. 

R2. Raben, N., Exelbert, R., Spiegel, R., Sherman, J. B Nakajima, H., Plotz, P., and Heinisch, J., Functional expression of human mutant phosphofructokinase in yeast Genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency. Am. J. Hum. Genet. 56, 131-141 (1995). 

Hinds, P. H., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I., and Weilberg, R. A. (1992). Regulation of the retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70 993-1006. 

Grinevich, V.P., Letchworth, S.R., Lindenberger, K.A. et al. Heterologous expression of human alpha 6 beta 4 beta 3 alpha 5 nicotinic acetylcholine receptors binding properties consistent with their natural expression require quaternary subunit assembly including the alpha 5 subunit. J. Pharmacol. Exp. Then 312 619, 2005. 

Bureik, M., Schiffler, B., Hiraoka, Y. et al. (2002) Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etpl. Biochemistry, 41 (7), 2311—2321. 

Kang, C.Y. (1997) Expression of human immunodeficiency virus genes using baculovirus expression system. Molecular Biotechnology, 8 (2), 173-187. 

Misaki, R., Fujiyama, K. and Seki, T. (2006) Expression of human CMP-V-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell. Biochemical and Biophysical Research Communications, 339 (4), 1184—1189. 

Ngo, L. Y., S. D. Patil, and J. D. Unadkat. Ontogenic and longitudinal activity of Na(+)-nudeoside transporters in the human intestine. Am. J. Physiol. 2001, 280, G475-G481. Chandrasena, G., etal. Functional expression of human intestinal Na+-dependent and Na+-independent nucleoside transporters in Xenopus laevis oocytes. Biochem. Pharmacol. 1997, 53, 1909-1918. 

Pennycooke, M., et al. Differential expression of human nucleoside transporters in normal and tumor tissue. Biochem. Biophys. Res. 

Fromm MF, Kauffmann HM, Fritz P, Burk O, Kroemer HK, Warzok RW et al. The effect of rifampin treatment on intestinal expression of human MRP transporters. Am J Pathol 2000 157(5) 1575—1580. 

Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y. cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3). FEBS Lett 1998 433(1—2) 149— 152. 

Kool M, van der LM, de Haas M, Baas F, Borst P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res 1999 59(1) 175 182. 

Lin M-F, Meng T-C, Rao PS, et al. Expression of human prostatic acid phosphatase correlates with androgen-stimulated cell proliferation in prostate cancer cell lines. J. Biol. Chem. 1998 273 5939-5947. 

In 2002, Ventria Bioscience published two papers describing the expression of human proteins in rice grains [74,75]. Lysozyme was expressed under the control of the glutelin 1 promoter, leader and signal peptide, and an expression level of 0.6% dry weight (equivalent to 45% of soluble proteins) was achieved [74]. As was the case for... 

Human serum albumin was the first full-length human protein to be expressed in the leaves of a transgenic plant (both tobacco and potato leaves were shown to express the protein). This report was published in 1990 [18]. Four years earlier, Barta and colleagues had demonstrated the expression of human growth hormone in tobacco and sunflower callus, and the protein was expressed as a fusion with the Agrohacterium tumefaciens nopaline synthase enzyme [17]. 

Co-expression of human tau with the fly homolog of GSK3-P resulted in accelerated neurodegeneration and the formation of tau-immunoreactive inclusions. In contrast to what has been described in FTDP-17 and mouse models of tauopathies, tau-induced neurodegeneration involved programmed cell death. Taken together, it appears that conformationally altered, nonfilamentous human tau protein is neurotoxic in invertebrates. 

P. D., Loftus, M., Stuehr, D. J., Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line H4B promotes assembly of enzyme subunits into an active dimmer, Proc. Natl. Acad. Sci. USA 92 (1995), p. 11771-11775... 

Wallner, B.P., Mattaliano, R.J., Hession, C., Cate, R.L., Tizard, R., Sinclair, L.K., Foeller, C., Chow, E.P., Browning, J.L., Ramachandran, K.L. and Pepinsky, R.B. (1986). Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 320 77-80. 

Munzel, P.A., Lehmkoster, T., Bruck, M., Ritter, J.K. and Bock, K.W. (1998) Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6. Archives of Biochemistry and Biophysics, 350, 72-78. 

A3. Axelrod, J. H., Reich, R., and Miskin, R., Expression of human recombinant plasminogen activator enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells. Mol. Cell. Biol. 9, 2133-2141 (1989). 

Nishimura M, Yaguti H, Yoshitsugu H, Naito S, Satoh T (2003) Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi 123(5) 369-375. 

Yokoyama, M., Y. Nakao, X. Yang, Q. Sun, K. Tsutsumi, A. Pater, and M. M. Pater. 1995. Alterations in physical state and expression of human papillomavirus type 18 DNA following crisis and establishment of immortalized ectocervical cells. Virus Res 37(2) 139-51. 

Apparsundaram S, Schroeter S, Giovanetti E, Blakely RD. (1998). Acute regulation of norepinephrine transport II. PKC-modulated surface expression of human norepinephrine transporter proteins. J Pharmacol Exp Ther. 287(2) 744-51. 

Yagi, K., Komura, S., Kojima, H., Sun, Q., Nagata, N., Ohishi, N., and Nishikimi, M., 1996, Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury. Biochem. Biophys. Res. Commun., 219 486-491... 

Lesuisse, C., Xu, G., Anderson, J., et al. (2001) Hyper-expression of human apoUpoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice. Hum. Mol Genet., 10, 2525-2537. 

The first system used to produce vaccines was potato plants and transgenic tubers have being employed in some clinical trials. Expression of vaccines is also reported in other hosts such as tomato, banana, carrot, lettuce, maize, alfalfa, white clover and Arabidospis. Hepatitis B surface antigen was successfully expressed in cherry tomatillo and potato. Expression of human cholera toxin p subunit was achieved in tomato and tobacco plants. ... 

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