Expression of GST in Human Tissues

The expression of the GST isoenzymes shows clear time- and tissue-specific expression during fetal, neonatal, and infant life. These changes are of interest 

The Bi subunit represents the major form of the total GST mass in the liver throughout development, with this subunit comprising approximately 80-90% of 

Developmental Changes in GST Expression in Liver, Kidney, and Lung 

GST levels were determined by radioimmunoassay and expressed as mg/g cytosolic protein. 

Immunohistochemistry of the alpha-class enzymes has shown that the tissue distribution is similar in both fetal and adult livers. Most staining is found in hepatocytes but not all hepatocytes appear to express the alpha-class enzymes. Hematopoietic and Kupffer cells, biliary epithelia, and the biliary canaliculi remain negative through development for alpha-class GST but the occasional positive cell is found in the large bile ducts of both the fetus and the adult (H40, S44). 

---