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Evaluation of Chemicals

The information included in the registration of the ca 5,000 substances exceeding a production or import volume of 100 tonnes per annum will have to be evaluated . The proposed Regulation foresees that national Competent Authorities will act on behalf of the ECA to do this work. [Pg.9]

When the volume reaches 100 tonnes per annum the manufacturer or importer has to make a proposal for a testing programme (according to Annex VII of the Regulation). The rapporteur Competent Authority, in consultation with other Competent Authorities and the ECA, agrees the final testing programme, and evaluates [Pg.9]


To become familiar with a knowledge-based reaction prediction system To appreciate the different levels in the evaluation of chemical reactions To know how reaction sequences are modeled To understand kinetic modeling of chemical reactions To become familiar with biochemical pathways... [Pg.542]

The evaluation of chemical reactions can be performed to various levels of sophistication heats of reaction allow for a consideration of the thermodynamics of a reaction, whereas reaction rates consider its kinetic aspects. [Pg.592]

R. L. WiUtias, Theoretical Evaluation of Chemical Propellants, Preatice Hall, lac.. New York, 1963. [Pg.57]

Initial evaluations of chemicals produced for screening are performed by smelling them from paper blotters. However, more information is necessary given the time and expense required to commercialize a new chemical. No matter how pleasant or desirable a potential odorant appears to be, its performance must be studied and compared with available ingredients in experimental fragrances. A material may fail to Hve up to the promise of its initial odor evaluation for a number of reasons. It is not at all uncommon to have a chemical disappear in a formulation or skew the overall odor in an undesirable way. Some materials are found to be hard to work with in that their odors stick out and caimot be blended weU. Because perfumery is an individuaHstic art, it is important to have more than one perfumer work with a material of interest and to have it tried in several different fragrance types. Aroma chemicals must be stable in use if their desirable odor properties are to reach the consumer. Therefore, testing in functional product appHcations is an important part of the evaluation process. Other properties that can be important for new aroma chemicals are substantivity on skin and cloth, and the abiHty to mask certain malodors. [Pg.84]

The evaluation of chemical-based veterinary medicines rests with the Center for... [Pg.35]

Evaluation of Chemical Characteristics of Irrigation Water Under Water Scarcity... [Pg.163]

Lewis DFV, loannides C, Parke DV. Validation of a novel molecular-orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the United States NCI NTP. Mut Res 1993 291 61-77. [Pg.493]

Cost factor. The calculation of CE is similar to current approaches of LCC analyses, again tailored to the evaluation of chemical synthesis strategies. CE includes (i) the costs of the supply of reactants, solvents and auxiliaries (ii) costs resulting from synthesis, (iii) workup, (iv) application and (v) disposal. Again, this effort is related to the molarity (or mass) of the product. [Pg.264]

Hoffmann, V.H., Hungerbuhler, K., McRae, G.J. (2001) Multiobjective Screening and Evaluation of Chemical Process Technologies. Industrial Engineering and Chemical Research, 40(21), 4513M524. [Pg.269]

Evaluation of chemical reaction hazards Industrial partner Reference... [Pg.371]

Promote the systematic application of all relevant scientific disciplines to the evaluation of chemical hazards. [Pg.219]

Shin JE. 1989. Evaluation of chemically-sensitive field-effect transistors for detection of organophosphorus compounds. Wright-Patterson AFB, OH Air Force Institute of Technology. NTIS No. AD-A215-536. [Pg.153]

Noda T, Mortia S, Ohgaki S. 1984. A Safety Evaluation of Chemicals Used in Household Products (V) Teratological Studies in 2-Ethylhexyl Diphenyl Phosphate in Rats. Annu Rep. Osaka City Inst. Public Health Environmental Science 46 82-88. [Pg.347]

Tomar M, Abdullah THA. 1994. Evaluation of chemicals to control the generation of malodorous hydrogen sulfide in waste water. Water Res 28 2545-2552. [Pg.202]

The advantages of developing such correlations is that once any of the parameters is known it is then a simple process to estimate the others. This is particularly useful in early evaluation of chemical partitioning in the environment. From a limited amount of information on a chemical, for example, its vapor pressure, water solubility and melting point, other partitioning parameters can be estimated and used in simple ecosystem models to evaluate the chemical s expected environmental distribution. [Pg.109]

At the fundamental level of equilibrium modeling the advantages are many. The model can combine a number of compartments through simple relationship to describe a realistic environment within which chemicals can be ranked and compared. Primary compartments that chemicals will tend to migrate toward or accumulate in can be identified. The arrangement of compartments and their volumes can be selected to address specific environmental scenarios. Data requirements are minimal, if the water solubility and vapor pressure of a chemical are known, other properties can be estimated, and a reasonable estimate of partitioning characteristics can be made. This is an invaluable tool in the early evaluation of chemical, whether the model be applied to projected environmental hazard or evaluation of the behavior of a chemical in an environmental application, as with pesticides. Finally, the approach is mathematically very simple and can be handled on simple computing devices. [Pg.121]

Act on the Evaluation of Chemical Substances and Regulation of Their Manufacture, etc. (Act No. 117 of October 16,1973 amended in 2009)], as well as their continued use by the U.S. Environmental Protection Agency (EPA) [Kavlock R, Dix D. J Toxicol Environ Health B Crit Rev 13(2-4) 197-217, 2010] and U.S. Food and Drug Administration (FDA) [U.S. Environmental Protection Agency (EPA) and U.S. Food and Drug Administration (FDA) TSCA (1976) Toxic Substances Control Act. United States Publ. Law 94-469, 90 Stat 2003, USA],... [Pg.74]

Among the possible alternative methods, in vitro assay (for ATMs) and quantitative structure-activity relationships (QSARs) models (for ANTMs) are the most applied approaches in the toxicological and ecotoxicological evaluation of chemicals profiles, even in the field of environmental research and risk assessment. [Pg.174]

We have already emphasized our view that the evaluation of chemical reactions and synthetic pathways is of preeminent importance in any system for computer-assisted synthesis design or reaction prediction. The quality of the evaluation process will determine to a large extent the overall quality of such a system. [Pg.38]

Since homolytic or radical processes are largely governed by the effects of bond dissociation energies, a knowledge of BDE is required for the evaluation of chemical reactivity in such reactions. However, we have found, as we mention later, that BDE s are also an important factor influencing other types of reactions involving bond heterolyses. [Pg.45]

Watson, A., D. Opresko, and V. Hauschild. Evaluation of Chemical Warfare Agent Percutaneous Vapor Toxicity Derivation of Toxicity Guidelines for Assessing Chemical Protective Ensembles, ORNL/TM-2003/180. July 2003. [Pg.104]

These QM/MM calculations are in contrast to a standard evaluation of chemical shielding for gas phase water clusters where the classical point charge environment is omitted entirely. The same solvation shell criterion as before was applied, and the system was treated purely quantum mechanically. [Pg.32]

Krzystyniak, K., Tryphonas, H. and Fournier, M., Approaches to the evaluation of chemical-induced immunotoxicity, Environ. Health Perspect., 103 Suppl. 9, 17, 1995. [Pg.16]

Kier, L. D. et al., Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro, Mutat. Res., 549, 101, 2004. [Pg.91]

In addition to the evaluation of chemical process hazards, and the proper applications of the evaluation to process design and operation, the management systems are important to assure operation of the facilities as intended. Brief introductions into hazard identification and quantification, and into management controls from the perspective of process safety are presented in Chapter 4. Future trends are also briefly reviewed here. [Pg.3]

The intent of this Guidelines book is to provide the principles for the evaluation of chemical reactivity and for use of this information to design and operate safer chemical plant processes. Special emphasis is placed on the use of state-of-the-art methodology in the areas of theory, testing methods, and applications in design and operation of inherently safer processes. [Pg.247]

Shimizu M, Noda T, Yamano T, et al. 1992. Safety evaluation of chemicals for use in household products (XVII). A teratological study on hexachloroethane in rats. Osaka City Institute of Public Health and Environmental Sciences 54 70-75. (Japanese) [translation in progress]... [Pg.159]

Kuri, C. J. and A. B. Corripio. Two Computer Programs for Equipment Cost Estimation and Economic Evaluation of Chemical Processes. Chem Engr Educ pp. 14-17 (Winter, 1984). [Pg.629]

An Overview of Quantitative Methods for Assessment and Evaluation of Chemical Risks... [Pg.184]

Zbinden, G. and Flury-Roversi, M. (1981). Significance of the LD50 Test for the toxicological evaluation of chemical substances. Arch. Toxicol. 47 77-99. [Pg.175]

David F. V. Lewis, Computer-Assisted Methods in the Evaluation of Chemical Toxicity. [Pg.441]

Plan Representation in SECS. The SECS Simulation and Evaluation of Chemical Synthesis program explicitly represents its plans(2) as a list structure of goal instructions with logical connectives. A goal instruction can specify one of the following ... [Pg.189]


See other pages where Evaluation of Chemicals is mentioned: [Pg.639]    [Pg.18]    [Pg.52]    [Pg.25]    [Pg.52]    [Pg.113]    [Pg.936]    [Pg.39]    [Pg.666]    [Pg.9]    [Pg.46]    [Pg.184]    [Pg.146]   


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