Basal cell

The role of the basal cells as stem cells for ciliated, goblet, and brush cells is expressed in their high mitotic capacity. Previously Drasch (1879) by 

Boers et al. (1998) studied normal human lungs (24-84 years) using the prohferation marker MlB-1 (Ki-67) on sections to stain for a labelhng index equivalent. Over 101000 were cells scored between 

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Interferons (lENs) (52,53), a family of species-specific vertebrate proteins, confer nonspecific resistance to a broad range of viral infections, affect cell proliferation, and modulate immune responses. AH three principal interferons, a-interferon (lEN-a) produced by blood leucocytes, P-interferon (lEN-P) by fibroblasts, and y-interferon (lEN-y) by lymphocytes, also have antiviral activity. The abiUty of interferons to inhibit growth of transplantable and carcinogen-induced tumor led to research showing the direct antiproliferative and indirect immune-mediated antitumor activities (see Chemotherapeutics, anticancer). IENs have been found to be efficacious in certain malignancies and viral infections, eg, hairy cell leukemia (85% response) and basal cell carcinoma (86% response). However, the interferons do have adverse side effects (54). 

There are hundreds of topical steroid preparations that are available for the treatment of skin diseases. In addition to their aforementioned antiinflammatory effects, topical steroids also exert their effects by vasoconstriction of the capillaries in the superficial dermis and by reduction of cellular mitosis and cell proliferation especially in the basal cell layer of the skin. In addition to the aforementioned systemic side effects, topical steroids can have adverse local effects. Chronic treatment with topical corticosteroids may increase the risk of bacterial and fungal infections. A combination steroid and antibacterial agent can be used to combat this problem. Additional local side effects that can be caused by extended use of topical steroids are epidermal atrophy, acne, glaucoma and cataracts (thus the weakest concentrations should be used in and around the eyes), pigmentation problems, hypertrichosis, allergic contact dermatitis, perioral dermatitis, and granuloma gluteale infantum (251). 

Basal cells Stem cells for other airway cell types that do not interface with... 

TLR7 Aldara Agonist Basal cell carcinoma Genital warts Approved... 

Basal cell carcinoma nodule with telan-... 

The physiological role of the ICOR is not clear and may be heterogeneous in the various tissues. In the thick ascending limb of the loop of Henle this channel appears to serve as the exit for CP at the basal cell pole [16,65,66], This conductive mechanism, therefore, is required for the reabsorption of Na and CP by this segment of the nephron [16]. In the rectal gland of Squalus acanthias a very similar channel is utilized for Na" and CP secretion. In these latter cells the CP-channel is present in the luminal membrane and is controlled by cytosolic cAMP [15,56,71]. It has been claimed that this kind of channel is also responsible for the secretion of CP in the colonic crypt cell, in colonic carcinoma cells and in respiratory epithelial cells [17,19,20,22]. Recent data have cast some doubt on this concept ... 

Fig. 2.16 Comparison of the fine structure of VNOR (right) with OR (left) cells. A = axon BL = basal layer C = cilia D = dendrite G = golgi GC = glial cell MV = microvilli, PC = primordial (basal) cell SER = smooth endoreticulum. TEM, scale bar 1.0 pm (from Mendoza, 1993).

RRM, relative risk for melanoma BCC, basal cell carcinoma NMSC, nonmelanoma skin cancer MM, malignant melanoma. 

O Exposure to ultraviolet radiation from the sun is recognized as one of the primary triggers for skin carcinogenesis. Based on their wavelengths, UV radiation is divided into three components UVA (320 00 nm), UVB (280-320 nm), and UVC (200-280 nm).15 UVB accounts for only 5% of the solar radiation that reaches the earth, but it is the primary carcinogenic component in the UV spectrum.15 The following sequence of events describes the process in which UV radiation causes skin cancer (1) UV radiation reaches the earth, and on the skin, it reaches the cells in the epidermal layer (i.e., squamous cells, basal cells, and melanocytes),16 (2) the UV radiation (specifically... 

Superficial Spreading Nodular Lentigo Maligna Melanoma Acral Lentiginous Basal Cell Carcinoma Squamous Cell Carcinoma... 

Three principal cell types exist in the corneal epithelium, namely, superficial cells, wing cells, and basal cells. A single layer of cuboidal basal cells is the sole site of cell division in the corneal epithelium. By necessity, these cells have more prominent mitochondria and Golgi apparatuses and hence high levels of metabolic and synthetic activities. Immediately above the basal cells is a zone comprising two to three layers of wing cells that are in an intermediate state of differentiation. 

The superficial cells are irregular arrays of polygonal cells with a diameter of 40-60 pm and a thickness of 2-6 pm each. These cells, the most differentiated cells of the epithelium, possess microvilli in their apical surfaces, which are covered with a glycocalyx. It is, however, controversial whether mucus exists on their surface [58,59], As cell division occurs in the basal cells of the cornea, the daughter cells move toward the surface while becoming more differentiated. As the daughter cells migrate toward the outermost layer, the superficial cells are... 

Evidence for the presence of a K+/H+ exchanger in the basal cells of corneal epithelium was also obtained by Bonanno [137], Elevated levels of intracellular K+ maintained by the basolateral Na+/K+-ATPase are utilized by K+/H+... 

While the lactate-H+ symporter and the K+/H+ exchanger are involved in acidification of the cell, the Na+/H+ exchanger present in the basal cells exports protons out of the cell in exchange for Na+ [139]. It was observed that removal of Na+ from the Ringer s solution decreased intracellular pH by 0.5 unit in basal cells, possibly due to inhibition of the Na+/H+ exchanger. As the basal cells are the precursors for the superficial cells of the corneal epithelium, it is quite likely that similar exchange processes are also present in the superficial layer, the principal barrier to ion and drug transport [99,103],... 

Basal cell carcinoma nodule with telangiectatic surface or ulcerated lesion with a pearly translucent border... 

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