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Endocarditis, treatment

Treatment — Various antibiotics are useful in treating Coxiella infections. They include tetracycline, doxycycline, and erythromycin. In cases of endocarditis, treatments with doxycycline combined with rifampin, and trimethoprim-sulfamethoxazole combined with doxycycline or tetracycline for 12 months or longer have been successful.3... [Pg.99]

Dodek P, Phillip P. Questionable history of immediate-type hypersensitivity to penicillin in staphylococcal endocarditis Treatment based on skin test results versus empirical alternative treatment—A decision analysis. Clin Infect Dis 1999 29 1251-1256. [Pg.2013]

Ampicillin (with gentamicin for immunosuppressed patients with meningitis) and penicillin G are the drugs of choice for infections with L. monocytogenes. The dose of penicillin G is 15-20 million units parenterally per day for at least 2 weeks. With endocarditis, treatment is for at least 4 weeks. [Pg.736]

When chronic Q fever infection is manifested by infective endocarditis, treatment is very difficult the mortality is 24% even when patients receive appropriate treatment.73 At least 2 years of therapy are required, usually with a tetracycline combined with rifampin or a quinolone, although tri-methoprim-sulfamethoxazole has also been used.84 Quinolones alone or in combination have also been effective. Most recently, the addition of hydroxychloroquine to tetracycline has shown promising results both in vitro87 and in a small number of patients.88... [Pg.531]

Infective endocarditis caused by these streptococci typically has a subacute clinical course. The current cure rate is often over 90% unless complications occur, which is the case in more than 30% of patients.17 The majority of viridans streptococci remain very susceptible to penicillin, with most strains having a minimum inhibitory concentration (MIC) of less than 0.125 mcg/mL.15,18 Organisms with decreased susceptibilities are increasing. Therefore, antibiotic susceptibilities need to be assessed in order to determine the most appropriate treatment regimen. [Pg.1093]

In patients with endocarditis of prosthetic valves or other prosthetic material caused by viridans streptococci and Streptococcus bovis, treatment courses are extended to 6 weeks (Table 37-5). [Pg.416]

ELISA) followed by Western blotting are used. As for treatment, doxicycline and rifampin for a minimum of six weeks. Ofloxacin plus rifampin is also effective. Therapy with rifampin, a tetracycline, and an aminoglycoside is indicated for infections with complications such as endocarditis or meningoencephalitis. [Pg.140]

Q fever endocarditis, and other firms of chronic Q fever (which is very rare) is much more difficult to treat. Such treatment is very complex, even controversial, and beyond the scope of this volume. [Pg.159]

Tetracycline 500 mg every six hours or doxycycline 100 mg every twelve hours for five to seven days will shorten the duration of illness, and fever usually disappears within one to two days after treatment is begun. Ciprofloxacin and other quinolones are active in vitro and should be considered for victims unable to take tetracycline or doxycycline. Successful treatment of Q fever endocarditis is much more difficult. Tetracycline or doxycycline given in combination with trimethoprim-sulfamethoxazole (TMP-SMX) or rifampin for twelve months or longer has been successful in some cases. However, valve replacement is often required to achieve a cure. [Pg.160]

Yes, but treatmert can be difficult, Doctors car prescribe effective antiiiotics. Usually, doxycvcline and rifampin are used in combination for 6 weeks to prevent reoccuring infection, Depending on the timing of treatment and severity of Blness, recovery may lake a few weeks to several months. Mortality is low (<2%), and is usually associated with endocarditis. [Pg.389]

Even newer is the natural product daptomycin (Cubicin), a complex cyclic lipopeptide structure, approved for use in the United States in 2003. Daptomycin has a spectrum similar to that of linezolid and specifically includes MRSA and VRE. In contrast to linezolid, daptomycin is bactericidal for these Gram-positive organisms. It is, like vancomycin, a parenteral antibiotic and is given intravenously. It is indicated for treatment of complicated skin and skin structure infections and for some cases of bacteremia, including endocarditis. Daptomycin may be thought of as an alternative to vancomycin. [Pg.328]

Duration - Duration of therapy varies with the type and severity of infection as well as the overall condition of the patient therefore, determine duration by the clinical and bacteriological response of the patient. In severe staphylococcal infections, continue nafcillin therapy for at least 14 days. Continue therapy for at least 48 hours after the patient has become afebrile and asymptomatic and cultures are negative. The treatment of endocarditis and osteomyelitis may require a longer duration of therapy. [Pg.1455]

IM Treatment of serious infections of mild to moderate severity where IM therapy is appropriate. Not intended for severe or life-threatening infections, including bacterial sepsis or endocarditis, or in major physiological impairments (eg, shock). [Pg.1529]

Clinical improvement, especially the disappearance of fever or defervescence, is the best parameter to judge the response to therapy. However, clinical improvement can be difficult to monitor objectively in critically ill patients with multi-system disease. Also, clinical improvement can be very slow for certain infections, e.g. tuberculosis. The peripheral blood leukocyte count including the presence of early stages in leucocyte differention and the level of serum C-Reactive Protein (CRP, an acute phase protein) are parameters that can be sequentially determined to monitor improvement. For monitoring the effect of treatment of chronic infections such as endocarditis or osteomyelitis, weekly determination of the erythrocyte sedimentation rate has been proven useful. [Pg.524]

The minimally required duration of treatment is only known for a limited number of infections. Clinical trials have shown the effectiveness of a single dose in the treatment of gonorrhoea or uncomplicated urinary tract infection in women and in surgical prophylaxis. The more precise duration of treatment has been studied for endocarditis, meningitis and staphylococcal bacteraemia. More often, guidelines for duration of treatment have been based on clinical experience with similar infections and on the parameters of response mentioned above. Failure of treatment should be recognised early. It can be due to a variety of reasons (Table 2). [Pg.525]

Empiric treatment for subacute endocarditis likely to be caused by penicillin-sensitive streptococci consists of high dose penicillin G (6 x 3 million units i.v. daily) plus gentamicin (1x3 mg/kg). In acute endocarditis a staphylococcal etiology is more likely and, therefore, gentamicin is combined with (flu)cloxacillin (6 x 2 g i.v. daily). [Pg.533]

In severe bacterial infections that are difficult to eradicate, such as endocarditis or osteomyehtis, it may be important to ensure that the patient s serum remains bactericidal at the lowest, or trough, concentration in the dosing interval. Dilutions of patient s serum can be incubated with the organism isolated from the patient and the minimum bactericidal concentration determined through serial dilutions. Treatment is considered adequate if the serum remains bactericidal at a dilution of 1 8. [Pg.511]

Vancomycin is also an effective alternative therapy for the treatment of staphylococcal enterocolitis and endocarditis. The combination of vancomycin and either streptomycin or gentamicin acts synergisticaUy against enterococci and is used effectively for the treatment or... [Pg.553]

Rifampin is a first-line antitubercular drug used in the treatment of all forms of pulmonary and extrapul-monary tuberculosis. Rifampin is an alternative to isoniazid in the treatment of latent tuberculosis infection. Rifampin also may be combined with an antileprosy agent for the treatment of leprosy and to protect those in close contact with patients having H. influenza type b and N. meningitidis infection rifampin is also used in methicillin-resistant staphylococcal infections, such as osteomyelitis and prosthetic valve endocarditis. [Pg.559]

Unlabeled Uses Treatment of bacterial endocarditis gonorrhea meningitis septicemia sinusitis and biliary tract, bone, joint, chancroid, chlamydial, intra-abdominal, skin, and soft tissue infections... [Pg.298]

Treatment of Bone, respiratory tract, skin and soft-tissue infections, endocarditis, peritonitis, and septicemia prevention of bacterial endocarditis in those at risk (if peniciiiin is contraindicated) when undergoing biliary, dental, GI, GU, or respiratory surgery or invasive procedures IV 500mgq6hor lgql2h. [Pg.1297]

It is used in all forms of tuberculosis along with other antitubercular drugs. Other indications are tularemia, plague, brucellosis, bacterial endocarditis, entero-coccal endocarditis. Used concomitantly with penicillin G for synergistic effect in the treatment of enterococcal endocarditis when other antibiotics are ineffective or contraindicated. [Pg.328]

It is used in the treatment of severe anaerobic infections caused by bacteroides and other anaerobes. It is also used in combination with aminoglycoside in the treatment of abdomen and GIT wounds, infections of female genital tract, pelvic abscesses, aspiration pneumonia and septic abortion. It is also used for prophylaxis of endocarditis. It is also used along with primaquine in Pneumocystis carinii pneumonia in AIDS patients and with pyrimethamine for toxoplasmosis. [Pg.333]


See other pages where Endocarditis, treatment is mentioned: [Pg.1997]    [Pg.2005]    [Pg.1997]    [Pg.2005]    [Pg.425]    [Pg.1023]    [Pg.1031]    [Pg.1095]    [Pg.1212]    [Pg.415]    [Pg.416]    [Pg.420]    [Pg.291]    [Pg.30]    [Pg.416]    [Pg.530]    [Pg.540]    [Pg.541]   
See also in sourсe #XX -- [ Pg.315 ]




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Endocarditis

Enterococcal endocarditis, treatment

Infective endocarditis treatment

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