Methoprim/sulfamethoxazole

When chronic Q fever infection is manifested by infective endocarditis, treatment is very difficult the mortality is 24% even when patients receive appropriate treatment.73 At least 2 years of therapy are required, usually with a tetracycline combined with rifampin or a quinolone, although tri-methoprim-sulfamethoxazole has also been used.84 Quinolones alone or in combination have also been effective. Most recently, the addition of hydroxychloroquine to tetracycline has shown promising results both in vitro87 and in a small number of patients.88... 

Alappan R, Perazella MA, Buller GK. Hyperkalemia in hospitalized patients treated with tii-methoprim-sulfamethoxazole. nn//itemMe[Pg.20]

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