Antileprosy agents

Rifampin is a first-line antitubercular drug used in the treatment of all forms of pulmonary and extrapul-monary tuberculosis. Rifampin is an alternative to isoniazid in the treatment of latent tuberculosis infection. Rifampin also may be combined with an antileprosy agent for the treatment of leprosy and to protect those in close contact with patients having H. influenza type b and N. meningitidis infection rifampin is also used in methicillin-resistant staphylococcal infections, such as osteomyelitis and prosthetic valve endocarditis. 

Use in conjunction with other antileprosy agents to prevent development of resistance... 

The development of diethyl dithioAophtalate (Etisul ) as an antituberculosis and antileprosy drug originated from the observation that ethyl mercaptan, an evil smelling, low boiling, inflammable liquid was active as an antitubercular agent. 

Reviews — Mayr s overview of chemotherapy has an excellent section on antibacterial chemotherapy. During the year antituberculous agents from the clinical viewpoint were reviwed, an assessment of isonlazid as a prophylactic was given, and a clinical review.of leprosy chemotherapy was given. The background and clinical activity of the antileprosy phenazine compound B-66, was reviewed by Chang and discussed by him as a vindication of his murine leprosy test. The status of leprosy prophylaxis with dap-sone and with BCG vaccination was discussed. The field of antiseptics and disinfectants was covered by Kretschmer. ... 

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