Diseases erythema

Perioral dermatitis is characterized by erythema, scaling and small papules and pustules symmetrically distributed around the mouth, sometimes extending to the nasolabial folds and the cheeks. This condition typically occurs in females 20-40 years of age. Topical corticosteroids can exacerbate the disease and should be avoided. 

In most instances, external-beam radiation therapy used in conjunction with breast-conserving procedures involves 4 to 6 weeks of radiation therapy directed to the breast tissue to eradicate residual disease. Complications associated with radiation therapy to the breast are minor and include reddening and erythema of the breast tissue and subsequent shrinkage of total breast mass beyond that predicted on the basis of breast tissue removal. Some clinical situations also require postmastectomy radiation therapy as well (see section on locally advanced breast cancer). 

Monitoring for disease resolution and side effects is critical to successful therapy. A positive response is noted with the normalization of involved areas of skin, as measured by reduced erythema and scaling, as well as reduction of plaque elevation. 

The common systemic manifestations of IBD include arthritis, anemia, skin manifestations such as erythema nodosum and pyoderma gangrenosum, uveitis, and liver disease. 

RT is administered to the entire breast over 4 to 6 weeks to eradicate residual disease after BCT. Reddening and erythema of the breast tissue with subsequent shrinkage of total breast mass are minor complications associated with RT. 

On significant inhalation of metallic mercury vapors, some people (primarily children) exhibit a syndrome known as acrodynia, or pink disease. Symptoms include severe leg cramps, irritability, erythema, and subsequent peeling of the hands, nose, and soles of the feet. ... 

Dermatologic diseases Pemphigus bullous dermatitis herpetiformis severe erythema multiforme (Stevens-Johnson syndrome) mycosis fungoides severe psoriasis angioedema or urticaria exfoliative, severe seborrheic, contact, or atopic dermatitis. 

The most common adverse reaction to etanercept is mild to moderate erythema, pain, or pruritus at the injection site (37%). Headaches and abdominal pain can also occur. New positive autoantibodies, such as antinuclear antibodies (ANA), anti-dsDNA antibodies, and anticardiolipin antibodies, can develop in patients treated with etanercept. Although there is so far no association between this and the development of autoimmune diseases or malignancies, long-term studies have yet to be done. Rare cases of pancytopenia may be associated with this drug. Although clinical trials showed no increased risk of infection with etanercept treatment, postmarketing reports of serious infections, sepsis, and associated fatalities exist. 

Thalidomide is approved for use in the United States for the treatment of cutaneous manifestations of erythema nodosum leprosum, a potentially life-threatening systemic vasculitis that occurs in some patients with leprosy. Although not approved for other indications, thalidomide has also been shown to be very effective in the management of Behget s disease, HIV-related mucosal ulceration (aphthosis), and select cases of lupus erythematosus. 

Intracutaneous Prepare a 10-international units/ml dilution withdraw 0.05 ml from a 200-international units/ml vial in a tuberculin syringe fill up to 1 ml with 0.9% NaCl. Take 0.1 ml and inject intracutaneously on inner aspect of forearm. Observe after 15 min a positive response is the appearance of more than mild erythema or wheal. Paget s disease IM, Subcutaneous Initially, 100 international units/day. Maintenance 50 international units/day or 50-100 international units every 1-3 days. Intranasal 200-400 international units/day... 

Unlabeled Uses Prevention and treatment of discoid lupus erythematosus, erythema multiforme, graft vs host reactions following bone marrow transplantation, rheumatoid arthritis treatment of Behget s syndrome, Crohn s disease, G1 bleeding, multiple myeloma, pruritus, recurrent aphthous ulcers in HIV patients, wasting syndrome associated with HIV or cancer... 

Salicylism and death have occurred following topical application. In an adult, 1 g of a topically applied 6% salicylic acid preparation will raise the serum salicylate level not more than 0.5 mg/dL of plasma the threshold for toxicity is 30-50 mg/dL. Higher serum levels are possible in children, who are therefore at a greater risk for salicylism. In cases of severe intoxication, hemodialysis is the treatment of choice (see Chapter 58). It is advisable to limit both the total amount of salicylic acid applied and the frequency of application. Urticarial, anaphylactic, and erythema multiforme reactions may occur in patients who are allergic to salicylates. Topical use may be associated with local irritation, acute inflammation, and even ulceration with the use of high concentrations of salicylic acid. Particular care must be exercised when using the drug on the extremities of patients with diabetes or peripheral vascular disease. 

A 33-year-old woman developed acute pancreatitis together with mild cholestatic hepatitis and erythema nodosum 1 month after starting carbimazole for Graves disease rechallenge with a single dose of carbimazole (10 mg) 7 days after initial recovery led to a further episode of acute pancreatitis, from which she recovered (54). 

Marazuela M, Sanchez de Paco G, Jimenez I, Carraro R, Fernandez-Herrera J, Pajares JM, Gomez-Pan A. Acute pancreatitis, hepatic cholestasis, and erythema nodosum induced by carbimazole treatment for Graves disease. Endocr J 2002 49(3) 315-8. 

Bleomycin (Blenoxane) causes chain scission and fragmentation of DNA. With the exception of the skin and lungs, most tissues can enzymatically inactivate bleomycin. Bleomycin is used in the management of squamous cell carcinoma of the head, neck, and esophagus in combination with other drugs in patients with testicular carcinoma, and in the treatment of Hodgkin s disease and other lymphomas. Bleomycin causes stomatitis, ulceration, hyperpigmentation, erythema, and pulmonary fibrosis. 

Workers are potentially exposed to a variety of substances during daily industrial operations. The OSHA estimates that a large segment of workers are simultaneously exposed to more than one substance and suffer from adverse effects. Adverse effects include many acute and chronic diseases (e.g., allergic sensitization, cancer, cardiovascular diseases, dermatitis, erythema, edema, irritation of the mucous membrane, irritation of the skin, kidney disease, liver disease, metabolic interferences, narcosis, neuropathy, ocular effects, odor effects, respiratory diseases, systemic toxicity). These should be properly addressed by concerned management and the individual worker to improve chemical safety. Workers come in contact directly or indirectly during different work conditions hence it is important to understand the possible adverse effects that these chemicals may cause vis-a-vis chemical safety. 

Vitamin A (in excessive doses) produces toxicity such as nausea, vomiting, erythema, dermatitis, hair loss, bone and joint pains, loss of appetite, bleeding, and chronic liver diseases. Excess vitamin A is teratogenic in animals and humans daily intake should not exceed 20,000 IU. 

Lyme disease, first reported in 1975, typically begins with a unique skin lesion, erythema chronicum migrans, accompanied by systemic symptoms. Late sequelae include neurologic or cardiac complications and arthritis. The disease is caused by a spirochete and is transmitted by ticks (S34). The majority of patients have Clq-reactive material in their sera early in the course of disease. In most patients immune complex levels subside. However, in those likely to develop neurologic or cardiac sequelae, immune complex levels persist, and, thus, the test is of prognostic value. Those patients... 

Groups of Special Interest. The responses of all 38 soldiers who experienced erythema or blisters as a result of exposure to mustard gas were examined in detail, because of the carcinogenic and mutagenic potential of this chemical (see Appendix A). None of the 38 mentioned cancer in response to the question of whether any health professional attributed a health problem to exposure (question 9) or the question of whether any disease or hospitalization had occurred in the preceding 5 years (question 13). One person mentioned cellulitis as a recent health problem, but his physician had not attributed this to the exposure. The mustard-damaged skin site (shoulder) was in a different location from the cellulitis (lower leg). 

Cirrhosis is often asymptomatic until complications of liver disease are present. Mrs MW may present with itching, jaundice, dark urine, pale fatty stools, abdominal pain, nausea, fatigue, bleeding - such as nose bleeds, hepatic encephalopathy, hepatomegaly, ascites, distended abdominal veins, spider angiomata, palmar erythema and asterixis. She may also present with the signs and symptoms of alcohol withdrawal, which include irritability, anxiety, tachycardia, tremor, sweating, confusion and hallucinations. 

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