Curcumin diabetes

Curcumin (diferuloyl methane) is the main pigment of turmeric. It is widely used as a colorant and preservative agent. No data regarding its daily intake in western countries are available intake may reach 80 to 200 mg in adult Indians. To date, no study has explored the effect of curcumin consumption on the incidence of diseases, but many beneficial effects on health have been reported in cell and animal models. These include anti-carcinogenic, anti-diabetic, anti-atherosclerotic, and anti-Alzheimer s disease properties. ... 

Sharma S, Chopra K, Kulkami SK. 2007. Effect of insulin and its combination with resveratrol or curcumin in attenuation of diabetic neuropathic pain Participation of nitric oxide and TNF-alpha. Phytother Res 21 278-283. 

Curcumin also enhances wound healing in diabetic rats and mice (Sidhu et al., 1999) and in H202-induced damage in human keratinocytes and fibroplasts (Phan et al., 2001). The wound healing effect is expressed by inhibiting the activation of NF-kappaB transcription factor through the prevention of the p65 unit of the factor. 

Dietary curcumin can alleviate dangerous secondary complications induced by diabetes. The beneficial effects of dietary curcumin on diabetic nephropathy are probably mediated through the hypolipidaemic effects of curcumin (Babu and Srinivasan, 1997). 

Curcumin has been proved to be an effective hypolipidaemic agent (Babu and Srinivasan, 1997). One study validated the role of dietary curcumin in maintaining healthy serum cholesterol levels in diabetic rats. Employing a high-cholesterol diet for the diabetic rats, curcumin exhibited a lowering of cholesterol and phospholipid in treated animals as compared with curcumin-free controls. Liver cholesterol, triglycerides and phospholipid elevated under diabetic conditions were lowered by dietary curcumin. Curcumin induces a... 

Babu, P.S. and Srinivasan, P. (1997) Hypolipidemic action of curcumin, the active principle of turmeric Curcuma longa in streptozotocin induced diabetic rats. Molecular and Cellular Biochemistry 166(1-2), 169-1 75. 

Sidhu, G.S. et a/. (1999) Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair and Regeneration 7, 362-374. 

From all these studies, it is clear that curcumin exhibits activities against cancer, cardiovascular diseases, and diabetes, the major ailments in the U.S. This dmg has also shown therapeutic effects against Alzheimer s disease, multiple sclerosis, cataract formation, HIV, and drag-induced nonspecific toxicity in the heart, lung, and kidney. Several of the studies estabhshing curcumin s potential were carried out in animals. Further testing of curcumin in humans is required to confirm these observations. A clinical development plan for using curcumin to treat cancer was recently described by the NCI. Studies also show that in countries such as India where curcumin is consumed. 

Babu, P.S. and Srinivasan, K., Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat. Mo/. Cell. Biochem., 152 (1), 13-... 

Morales J, Dunbar JC, Ram JL (2002) Effect of aldose reductase inhibition on interleukin-ip-induced nitric oxide (NO) synthesis in vascular tissue. Int J Exp Diabetes Res 3(1) 11-20 Muthenna P, Suryanarayana P, Gunda SK, Petrash JM, Reddy GB (2009) Inhibition of aldose reductase by dietary antioxidant curcumin mechanism of inhibition, specificity and significance. EEBS Eett 583(22) 3637-3642... 

Weisberg SP, Leibel R, Tortoriello D V (2008) Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 149 3549-3558. doi 10.1210/en.2008-0262... 

Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of diabetes mellitus. There is evidence for increased levels of circulating ROS in diabetics, as inferred by the increased lipid peroxidation. Streptozotocin-induced diabetic rats maintained on a 0.5% curcumin diet for 8 weeks showed lowered lipid peroxidation in plasma and urine when compared to control diabetic group (Babu and Srinivasan 1995). The effect of chronic curcumin treatment (200 mg/kg) on the oxidative stress in streptozotocin-diabetic rats was studied at four weekly intervals up to 24 weeks (Majithiya and Balaraman 2005). Curcumin treatment significantly reduced lipid peroxidation. 

Dietary curcumin (0.002% and 0.01%) and turmeric (0.5%) are found to be effective against the development of diabetic cataracts in diabetic rats (Suryanarayana et al. 2005). Curcumin and turmeric supplements... 

Majithiya, J.B. and Balaraman, R. 2005. Time-dependent changes in antioxidant enzymes and vaseular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcumin. J. Cardiovasc. Pharmacol., 46 697-705. 

Sajithlal, G.B., Chithra, P., and Chandrahasan, G. 1998. Effect of curcumin on the advanced glyca-tion and cross-linking of collagen in diabetic rats. BiochemFharmacol. 56 1607-1614. 

Sidhu, G.S., Mani, H., Gaddipati, J.P., Singh, A.K., Seth, P., Banaudha, K.K., Patnaik, G.K., and Maheshwari, R.K. 1999. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen. 7 362-374. 

Srinivasan, M. 1972. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J. 

Suryanarayana, P., Saraswat, M., Mrudula, T., Krishna, T.P., Krishnaswamy, K., and Reddy, G.B. 2005. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest. Ophthalmol Vis. Sci., 46 2092-2099. 

Turmeric exfracfs have recenfly exhibited efficacy in managing fype-2 diabetes hyper-glycemia and reducing fhe side effecls (nephrofoxicify and cafaracf) of induced hy-perglycemia by fargefing fhe peroxisome proliferalor-aclivaled receptor (PEAR) and due to fheir anfioxidanf acfivify, respecfively. Curcumin was also able fo reduce hyperlipidemia in diabefic rafs by increasing cholesterol cafabolism. ... 

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