DNA damage inducible

Possible Mechanisms of DNA Damage Induced by Oxidative Stress... 

Breimer, L.H. (1991). Repair of DNA damage induced by reactive oxygen species. Free Rad. Res. Commun. 14, 159-171. 

Epe, B., Pflaum, M., Haring, M., Hegler, J. and Rudiger, H. (1993). Use of repair endonucleases to characterize DNA damage induced by reactive oxygen species in cellular systems. Toxicol. Lett. 67, 57-72. 

Kasai, H. and Nishimura, S. (1984). DNA damage induced by asbestos in the presence of hydrogen peroxide. Gann 75, 841-844. 

Oikawa, S. Hirosawa, I. Hirakawa, K. Kawanishi, S. Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol. Carcinogenesis 2001, 22, 1239-1245. 

Sakano, K. Inagaki, Y. Oikawa, S. Hiraku, Y. Kawanishi, S. Copper-mediated oxidative DNA damage induced by eugenol possible involvement of O-demethylation. Mutat. Res. 2004, 565, 35 44. 

Oxaliplatin (Eloxatin ) is similar to other platinum analogs (e.g., cisplatin) in that it binds to the N-7 position of guanine, which results in cross-linking of DNA and double-stranded DNA breaks.26,40 Oxaliplatin differs from cisplatin in that the DNA damage induced by oxaliplatin may not be as easily recognized by DNA repair genes often seen in colorectal cancer. Oxaliplatin, in combination with 5-FU-based regimens, is indicated for the first- and second-line treatment of metastatic colon cancer, as well as the adjuvant treatment of colon cancer. 

Zhu, L. et al. (2007) DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Letters Issues, 7 (12), 3592-3597. 

McCarroll, N.E., C.E.Piper, and B.H.Keech. 1981. An E. coli microsuspension assay for the detection of DNA damage induced by direct-acting agents and promutagens. Environ. Mutagen. 3 429-444. 

Human sperm chromosomes retain a high fertilizing ability after a high dose of X-irradiation, although mammalian spermatozoa have little capacity to repair DNA damage induced by radiation (Kamiguchi et al. 1990). Radiation-induced death of lymphoid cells in rats is associated with damage to the cell itself but may also be due to secretions from irradiation-activated natural killer cells that induce pycnosis and interphase death in lymphoid cells (Eidus et al. 1990). 

Figure 5.9 Comparison of DNA damage induced by [Ru( s-p-cymene)Cl2(pta)] incubated at different pH values shown by DNA migration in an agarose gel. Reproduced by Permission of the Royal Society of Chemistry...

Kawai, H., et al., DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem,... 

M., Divita, G., and Reed, S. I., UBA domains of DNA damage-inducible proteins interact with ubiquitin, Nat. Struct. Biol, 2001, 8, 417. 

Acetylation levels of histone and non-histone proteins are regulated upon DNA damage. Retinoblastoma protein pRb controls Gl-S phase transition and phosphorylation of pRb regulates it function. DNA damage induced acetylation of pRb near the phosphorylation sites prevents it phosphorylation and keep pRb in active form thereby leading to growth repression. DNA damage dependant association... 

Blander G, Zalle N, Daniely Y, Taplick J, Gray MD (2002). DNA Damage-induced Translocation of the Werner helicase is regulated by acetylation. J Biol Chem 277(52) 50934-50940... 

Eernandez-Capetillo O, Allis CD, Nussenzweig A (2004) Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med 199(12) 1671—1677 Eernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A (2002) DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4(12) 993-997... 

S. Janssens and J. Tschopp, Signals from within the DNA-damage-induced NF-kappaB response. Cell. Death Differ., 2006, 13(5), 773. 

Figure 5.16 Association of DNA damage-inducible gene (GADD45) expression during tetracycline induction of the BRCAl gene. (From Mullan, RB. et al., Biochem. Soc. Trans., 29, 678-683, 2001. With permission.)...

Weber E, Bannasch P Dose and time dependence of the cellular phenotype in rat hepatic preneoplasia and neoplasia induced by continuous oral exposure to N-nitrosomorpholine. Carcinogenesis 15 1235-42, 1994 Robbiano L, Mereto E, Corbu C, et ah DNA damage induced by seven N-nitroso compounds in primary cultures of human and rat kidney cells. Mutat Res 368(l) 41-7, 1996... 

Blattner C, Tobiasch E, Litfen M, Rahmsdorf HJ, Herrlich P (1999) DNA damage induced p53 stabilization no inchcation for an involvement of p53 phosphorylation. Oncogene 18 1723-1732... 

Terrell J, Shih S, Dunn R, Hicke L (1998) A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell 1 193-202 Tomoda K, Kubota Y, Kato J (1999) Degradation of the cydin-dependent-kinase inhibitor p27 is instigated by Jabl. Nature 398 160-165 Toyoshima F, Moriguchi T, Wada A, Fukuda M, Nishida, E (1998) Nudear export of cydin Bl and its possible role in the DNA damage-induced G2 checkpoint. EMBO J 17 2728-2735... 

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