Streptozotocin diabetics

FIGURE 12 Effect of insulin released from microspheres of PCPP-SA 50 50 injected subcutaneously in streptozotocin-diabetic rats. Details were as described in the text. 

YANG J A, CHOI J H and RHEE s J (1999) Effect of green tea catechin on phospholipase A2 activity and antithrombus in streptozotocin diabetic rats , JNutr Sci Vitaminol (Tokyo), 45 (3), 337-46. 

Schein, P.S., Cooney, D.A. and Veron, M.L. (1967). The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumour activity Cancer Res. 27, 2324-2332. 

Yew, M.S. (1983). Effect of streptozotocin diabetes on tissue ascorbic acid and dehydroascorbic acid. Horm. Metab. Res. 15, 158. 

It should be mentioned that the inhibition of superoxide overproduction and lipid peroxidation by lipoic acid has been recently shown in animal models of diabetes mellitus. The administration of LA to streptozotocin-diabetic rats suppressed the formation of lipid peroxidation products [213], In another study the supplementation of glucose-fed rats with lipoic acid suppressed aorta superoxide overproduction as well as an increase in blood pressure and insulin resistance [214]. 

Sanders et al. [133] found that although quercetin treatment of streptozotocin diabetic rats diminished oxidized glutathione in brain and hepatic glutathione peroxidase activity, this flavonoid enhanced hepatic lipid peroxidation, decreased hepatic glutathione level, and increased renal and cardiac glutathione peroxidase activity. In authors opinion the partial prooxidant effect of quercetin questions the efficacy of quercetin therapy in diabetic patients. (Antioxidant and prooxidant activities of flavonoids are discussed in Chapter 29.) Administration of endothelin antagonist J-104132 to streptozotocin-induced diabetic rats inhibited the enhanced endothelin-1-stimulated superoxide production [134]. Interleukin-10 preserved endothelium-dependent vasorelaxation in streptozotocin-induced diabetic mice probably by reducing superoxide production by xanthine oxidase [135]. 

Choi JS, Yokozawa T, Oura H. (1991) Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prams davidiana stems and its main component, prunin. Planta Med 57 208-211. 

Baluchnejadmojarad T, Roghani M. (2008) Chronic administration of genistein improves aortic reactivity of streptozotocin-diabetic rats Mode of action. Vascul Pharmacol 49 1-5. 

Andrade-Cetto A, Wiedenfeld H. (2001) Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J Ethnopharm 78 145-149. 

Muruganandan S, Srinivasan K, Gupta S, Gupta PK, Lai J. (2005) Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats. J Ethnopharm 97 497-501. 

Chandramohan G, Ignacimnthn S, Pngalendi KV. (2008) A novel componnd from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats. Eur J Pharmacol 590 437-443. 

Tchemyashova V, Olestchuk O, Nikolaev V et al (2008) Study of efficacy of use of Enterosgel in a model of experimental streptozotocine diabetes. Visnyk Farmakologh i Farmatsh 3 33-37 (In Ukrainian)... 

Jensen LJ, Denner L, Schrijvers BF, Tilton RG, Rasch R, Flyvbjerg A. 2006. Renal effects of a neutralising RAGE-antibody in long-term streptozotocin-diabetic mice. J Endocrinol 188(3) 493-501. 

Weber, L.P., and K.M. Macleod. 1997. Influence of streptozotocin diabetes on the alpha-1 adrenoceptor and associated G proteins in rat arteries. J. Pharmacol. Exp. Ther. 283 1469-1478. 

Chang et al. (1983) studied ciglitazone in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. 

Similarly, Coriandrum sativum (coriander) has also been used as a traditional treatment of diabetes. The coriander incorporated into the diet and drinking water could reduce the hyperglycaemia of the streptozotocin-diabetic mice. Administration of the aqueous extract of coriander increased the 2-deoxyglucose transport (1.6-fold), glucose oxidation (1.4-fold) and incorporation of glucose into glycogen (1.7-fold) of the isolated murine abdominal muscle, more efficiently than insulin. In acute 20 min tests, the aqueous... 

In the ob/ob mouse, the KK mouse and the Zucker rat, CS-045 reduces the levels of blood glucose, insulin, triglycerides, lactate, and free fatty acids, while in the normal rat and the streptozotocin-diabetic rat, no effect on blood glucose is observed. The effect on blood glucose in KK mice can be observed after a single 50 mg/kg dose within 2.5 hours and lasts as long as... 

A newer agent, RC-160 (59), was tested in streptozotocin-diabetic rats. Injection of RC-160 subcutaneously inhibits glucagon release and lowers plasma glucose levels [303]. 

Ro 16-8714 (84) is a tertiary amine also developed as an antiobesity agent. It normalizes blood glucose in ob/ob mice [376] and in streptozotocin-diabetic rats [377] by increasing glucose oxidation. A euglycaemic clamp in fa/fa rats determined that the compound increases both basal and insulin-stimulated glucose utilization in brown adipose fat, the tissue in... 

Kastin AJ, Akerstrom V (2001) Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice. Neuroendocrinology 73 237-242. 

Fig. 6 Plasma metformin concentrations following the administration of metformin (450mg/kg) as PO bolus, duodenal infusion, and gastroretentive CR tablets (CR I or CR II) to streptozotocin-diabetic rats. (From Ref...

Miric G, Dallemagne C, Endre Z, Margolin S, Taylor SM, Brown E Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats. Br J Pharmacol 133 687-94,2001... 

Anderson T, Schein PS, McMenamin MG, and Gooney DA. Streptozotocin diabetes. Correlation with extend of depression of pancreatic islet nicotinamide adenine dinucleotide. J Clin invest 54 672-677,1974... 

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