Anti-diabetics

Antidiabetic Drugs other than Insulin. Table 4 Main exclusions, adverse events and precautionary monitoring required for clinical use of oral anti-diabetic drugs... 

List some nursing diagnoses particular to a patient taking an anti diabetic drug. 

SUMMARY DRUG TABLE ANTI DIABETIC DRUGS... 

Sabu, M.C. Ramadasan, K (2002). Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. Journal of Ethnopharmacology, Vol. 81, No.2, (July 2002), pp. 155-160, ISSN 0378-8741. 

Diabetic patients have reduced antioxidant defences and suffer from an increased risk of free radical-mediated diseases such as coronary heart disease. EC has a pronounced insulin-like effect on erythrocyte membrane-bound acetylcholinesterase in type II diabetic patients (Rizvi and Zaid, 2001). Tea polyphenols were shown to possess anti-diabetic activity and to be effective both in the prevention and treatment of diabetes (Choi et al, 1998 Yang et al, 1999). The main mechanism by which tea polyphenols appear to lower serum glucose levels is via the inhibition of the activity of the starch digesting enzyme, amylase. Tea inhibits both salivary and intestinal amylase, so that starch is broken down more slowly and the rise in serum glucose is thus reduced. In addition, tea may affect the intestinal absorption of glucose. 

FUJITA H, YAMAGAMi T (2001) Fermented soybean-derived Touchi-extract with anti-diabetic effect via alpha-glucosidase inhibitory action in a long-term administration study with KKAy mice. Life Sci. 70 219-27. 

Curcumin (diferuloyl methane) is the main pigment of turmeric. It is widely used as a colorant and preservative agent. No data regarding its daily intake in western countries are available intake may reach 80 to 200 mg in adult Indians. To date, no study has explored the effect of curcumin consumption on the incidence of diseases, but many beneficial effects on health have been reported in cell and animal models. These include anti-carcinogenic, anti-diabetic, anti-atherosclerotic, and anti-Alzheimer s disease properties. ... 

Jager and coworkers have used the TBAF catalyzed-stereoselective nitro-aldol reaction for the synthesis of cyclic amino alcohols such as iminopolyols, imino sugars, and cyclic amino acids. They are important classes of compounds and have the potential utility as anti-diabetic,... 

Methylpyrazine-2- Glipicide Anti-diabetic Oxidation Pseudomonas putida Single-stage fermentation [6]... 

Insulin was first identified as an anti-diabetic factor in 1921, and was introduced clinically the following year. Its complete amino acid sequence was determined in 1951. Although mature insulin is a dimeric structure, it is synthesized as a single polypeptide precursor, i.e. preproinsulin. This 108 amino acid polypeptide contains a 23 amino acid signal sequence at its amino terminal end. This guides it through the endoplasmic reticulum membrane, where the signal sequence is removed by a specific peptidase. 

Misoprostol, bromocriptine, metformin and valproate. Anti-diabetic agents... 

Although significant in vivo anti-diabetic effects have been reported, this did not translate into strong in vitro anti-glycation and antioxidant activities. There may be stronger in vivo antioxidant and anti-glycation activities, which will be an important area of future investigation. 

Anti-Diabetic Agents of Natural Origin A Retrospective Account of Some Promising Chemotypes... 

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