Beta-catenin

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Haet, M. et al. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol 1999, 9, 207-10. 

PoiAKis, P. The oncogenic activation of beta-catenin. Curr Opin Genet Dev 1999, 9, 15-21. 

Hubee, a. H., Nelson, W. J. and Weis, W. 1. Three-dimensional structure of the armadillo repeat region of beta-catenin. Cdl 1997, 90, 871-82. 

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Zhang, Z., Hartmann, H., Minh Do, V., et al. (1998) Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature, 395, 698-702. 

Fischer AN, Fnchs E, Mikula M, Huber H, Beug H, Mikulits W (2006). PDGF essentially links TGF beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene [Epub ahead of print]. 

Koh, S.S., Li, H., Lee, Y.H., Widelitz, R.B., Chuong, C.M. and Stallcup, M.R. (2002) Synergistic coactivator function by coactivator-assodated arginine mefhyltransferase (CARM) 1 and beta-catenin with two different dasses of DNA-binding transcriptional activators. The Journal of Biological Chemistry, 277, 26031-26035. 

Stucke VM, Corses D, Hofmann F (2008) DEAD-box RNA helicase p68 is not required for nuclear translocation of beta-catenin in colon cancer cells. Cell Cycle 7 830-832... 

Fig. 4. Protein contact surface representation of the beta-catenin/Tcf4 protein compiex interface near Tcf4 (D16). The QSURF coior-coded surface highiight two protein micro-cavities that anchor the ligand PNU-74654 at two opposite sites orange dot circle) involving a methyl-furan moiety and a benzene ring.

Poy F, Lepomcelet M, Shivdasani RA et al (2001) Sttucture of a hiunan Tcf4-beta-catenin complex. Nat Struct Biol 8 1053-1057... 

Trosset J-Y, Dalvit C, Knapp S et al (2006) Inhibition of protein-protein interactions the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 64 60-67... 

FasoKni M, Wu X, Flocco M et al (2003) Hot spots in Tcf4 for the interaction with beta-catenin. J Biol Chem 278 21092-21098... 

Verma UN, Surabhi RM, Schmaltieg A et al (2003) Small interfering RNAs directed against beta-catenin inhibit the in vitro and in vivo growth of colon cancer cells. Clin Cancer Res 9 1291-1300... 

Moon RT, Bowerman B, Boutros M et al (2002) The promise and perils of Wnt signaling through beta-catenin. Science 296 1644-1646... 

Lamarre, M. and Desrosiers, R. R. (2008). Up-regulation of protein L-isoaspartyl methyl-transferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization. Neuropharmacology 55, 669-676. 

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Robbins PF, El-Gamil M, Li YF, Kawakami Y, Loftus D, Appella E, Rosenberg SA (1996) A mutated beta-catenin gene encodes a melanoma-specific antigen recognized by tumor infiltrating lymphocytes. J Exp Med 183(3) 1185—1192... 

Murga C, Fukuhara S, Gutkind JS (2000) A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J Biol Chem 275(16) 12069-12073 Novak A, Dedhar S (1999) Signaling through beta-catenin and LelTTcf. Cell Mol Life Sd 56(5-6) 523-537... 

Meigs, T. E., Fields, T. A., McKee, D. D., and Casey, P.J. (2001). Interaction of G alpha 12 and G alpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta-catenin release. Proc. Natl. Acad. Sci. USA 98, 519-524. 

Chen, X., Bonne, S., Hatzfeld, M., van Roy, F., and Green, K.J. (2002). Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta-catenin signaling. J. Biol. Chem. 277, 10512-10522. 

Miravet, S., Piedra, J., Castano, J., Raurell, I., Franci, C., Dunach, M., and Garcia de Herreros, A. (2003). Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription. Mol. Cell. Biol. 23, 7391-7402. 

Nelson, W. J., and Nusse, R. (2004). Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303, 1483-1487. 

Matsuzawa SI, Reed JC. 2001. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. Mol Cell 7(5) 915—926. 

Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Salter DM. 2000. Integrin and mechanosensitive ion channel-dependent tyrosine phosphorylation of focal adhesion proteins and beta-catenin in human articular chondrocytes after mechanical stimulation. J Bone Miner Res 15 1501-9. 

Chesire DR, Dunn TA, Ewing CM, Luo J, Isaacs WB. Identification of aryl hydrocarbon receptor as a putative Wnt/beta-catenin pathway target gene in prostate cancer cells. Cancer Res 2004 64 2523-2533. 

Yuan, J., Zhang, J., Wong, B.W., Si, X., Wong, J., Yang, D., and Luo, H. (2005). Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin. Cell Death Differ 12, 1097-1106. 

Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., et al. 1993. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cehs transformed with a temperature-sensitive v-SRC gene. J. Cell Biol. 120 757-766. 

Kaidanovich-Beilin, O., Milman, A., Weizman, A., Pick, C.G., and Eldar-Finkelman, H., 2004, Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol. Psychiatry 55 781-784. 

B. M. Gumbiner. Signal transduction of beta-catenin. Curr Opin CeU Biol, 7, (5), 634 640, 1995. 

B. Rubinfeld, I. Albert, E. Porfiri, C. Fiol, S. Munemitsu, and P. Polakis. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly [see comments]. Science, 272 (5264), 1023-1026, 1996. 

M. J. Hart, R. de los Santos, I. N. Albert, B. Rubinfeld, and P. Polakis. Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Bid, 8, (10), 573-581, 1998. 

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