Collaborative development process

Many aspects of the Catalysis process can be modeled using the concepts of type, collaboration, and refinement. When you re modeling the development process itself, the interesting development objects and actions include the following ... 

The development process starts with a thorough planning step in which a development plan is generated by the collaboration of all stakeholders, such as quality assurance (QA), QC sourcing sites, stability, development, and regulatory functions. Planning should also include information gathering to obtain ... 

FIGURE I Schematic overview of an advanced method development process. Method development is a continuous process in which all stakeholders collaborate intensively to design the final method. Reprinted with permission from reference I. 

In the case of HR-NMR the main stipulation is that all samples introduced to the analyzer must be in an entirely liquid form in order for the protons in the entire molecular distribution to be observed. Solids will not provide observable H signals and their presence will therefore reduce the efficacy of the on-line predictions or the model development. A sampling tap from the process lines must deliver separate streams (up to five) to the sample system at a flow rate of 260-340 liters per hour. The sample system must be designed to provide each sample stream to the NMR probe with a temperature variation of less than 3°C. Each sample system is custom designed to meet the above criteria by working in close collaboration with process engineers on the temperature, flows, pressures, viscosities, and solids content found in the various process lines. 

Development is the conversion of a biologically active compound into a safe marketable product. It is a multi-disciplinary process, which requires the collaboration of teams of workers from many different disciplines. Its success is dependent on their skills and judgement. This chapter will outline the work carried out by these teams in the main areas of the development process. The activities in many of these areas are interdependent, which means that they should take place consecutively or at the same time. Consequently, as speed is of the essence in all development work, these activities will require careful planning and coordination. 

Other companies showing strong interest in the production of biobased succinic acid and its derivatives are Mitsubishi Chemical and Ajinomoto Company, Inc., which have agreed to collaboratively develop a biobased process to convert sugars into succinic acid. These companies plan to construct a succinic acid plant in Japan with an initial capacity of 30,000 metric t/yr (MT) by 2006 (42). Table 4 shows the current market estimates for the fossil-based chemicals, as well as 2020 market estimates for the biobased products potentially based on biobased succinic acid. 

Background. Once indicators are selected, baseline practice data must be measured in order to determine current practices. This step is important to objectively denote the current practice, make sure all major stakeholders are involved in the improvement process, and set the stage for problem solving. CQI should be data driven, so that measurement of current practice by collaboratively developing quality indicators clearly defines the extent of the problem. It is important to measure the baseline data at several time... 

In summary, there is a wealth of molecular information and stractural diversity available from a wide variety of suppliers of screening libraries. These resources are becoming more and more a key part of the pharmaceutical research and development process and are no longer simply regarded as a source of cheap or poor quality structures. Those providers who recognise the need for better quality molecules that fit descriptors for lead- or drug-likeness will be the ones who are likely to benefit the most from this recognition. In turn, those benefits will be passed back to the research and development community as a further improvement in supply and collaboration. 

Process chemistry is a large functional area that can have major impacts on a drug s developability, but it will not be covered in this book. Although the developability criteria in this area will not be discussed here, it is important to point out that quite often collaboration with process chemists is also required early on in order to find the right salt and solid state form. 

Collaborative Virtual Reality environments are needed for such complex tasks as designing and optimizing an extruder by studying the flow phenomena in detail. Although visualization is much more complex in this case, it was shown that event sharing can be used also in distributed VR applications. Studying the impact on and the possibilities of VR in specific development processes is a rather new field of research in engineering and computer science. 

These areas of application were not yet fully foreseeable when the scenario was compiled. This contributed to the fact that the scenario had to be expanded in the final phase of IMPROVE in order to even realize a simulation. This extension was done in collaboration with process engineering experts. Besides temporal information about individual activities, it also encompasses the influence of tool usage and the competences of the developers involved. This information can be accounted for in the simulation, though it is not based on a valid foundation. For this reason, it is necessary to collect additional information by modeling new design processes in this transfer project to... 

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