5-chloro-2- -1 -methyl

Pyran, 3,4-dihydro-, 55, 63 Pyran, tetrahydro-, 2,3-dichIoro- [2//-Pyran, tetrahydro-, 2,3-dichloro-], 55, 63 Pyran, tetrahydro-, 3-chloro-2-methyl- [2H-Pyran, tetrahydro-, 3-chloro-2-methyl-], 55 63... 

Pyran, tetrahydro 3 chloro 2 methyl [Pyran, tetrahydro-3-chloro-2-mcth-... 

CN yV-[3 Chloro-2-[[methyl[2-(4-morpholinyl)-2-oxoethyl]aminoJmethyl]phenyl]benzamide... 

Methallyl chloride 1-Propene, 3-chloro-2-methyl- (8,9) (563-47-3) 2-(Hydroxymethylene)cyclododecanone Cyclododecanone, 2-(hydroxymethylene)-(9) (949-07-5)... 

The best alternative preparation of 3-chloro-2-(chloromethyl)-1-propene involves the direct chlorination of 3-chloro-2-methyl-1-propene using elemental chlorine.4 This method leads to a mixture of products that must be purified by a tedious spinning band distillation, and only yields 34% of the desired product. 

In another paper from the Jackson Laboratories of the du Pont Company (Calcott et al., 34) there is reported a repetition of some of the reactions of Simons and Archer, as well as additional ones. Mono-, di-, and 1,2,4,5 tetraisopropylbenzene were obtained from propylene and benzene both l -chloro-i-butylbenzene and di-(l/-chloro)-d-butylben-zene were obtained from 3-chloro-2-methyl-propene-l and benzene p-f-butyltoluene and di-i-butyltoluene were obtained from diisobutylene and toluene tetraisopropylnaphthalene was obtained from propylene and naphthalene naphthyl-stearic acid was obtained from oleic acid and naphthalene mixed isopropyltetrahydronaphthalene was obtained from propylene and tetrahydronaphthalene 2,4,6-triisopropylphenol was obtained from propylene and phenol a mixture of monoisopropylated m-cresols was obtained from propylene and wi-cresol and di-(s-hexyl)-diphenyl oxide was obtained from hexene-3 and diphenyl oxide. 

Irradiation of compound 357 (R = Me) in methanol and ethanol at 300 nm gave ethyl 2-methyl-4-oxo-4//-pyrimido[2,l-a]isoquinoline-3-car-boxylate (371) and 3-alkoxy-2-methyl 4//-pyrimido[2,l-a]isoquinoline-4-ones (369, R = Me, R1 = Me, Et) along with two imidazo[2,l-a]isoquino-lines (368, R = Me and 372) and a ring-opened product (92AJC1811). At 254 nm the yields of 4//-pyrimido[2,l-a]isoquinolin-4-ones (369, R = Me and 371) and 368, (R = Me) were lower no formation or trace of them was observed in acetonitrile, acetone, acetic acid, and ethyl acetate. Irradition of compound 357 (R = Me) at 300 nm in acetonitrile containing 36% hydrochloric acid afforded 3-chloro-2-methyl-4//-pyrimido[2,l-a]isoquinolin-4-one (373) in 31-81% yields and other products. 

TABLE 10 Chiral Resolutions of Some Drugs on 3-Chloro-4-methyl (CSPs 8 and 15, Bonded to Silica via the Narrow Opening of CD) and 3-Chloro-2-methyl (CSPs 13 and 16, Bonded to Silica via the Wider Opening of CD) Phenylcarbamate Derivatives of... 

Chloromethylphenyl acetate, (4-Acetoxyphenyl)methyl chloride, see 4-Acetoxybenzyl chloride, 3132b 2-Chloro-5-methylphenylhydroxylamine, 2792 Chloromethylphenylsilane, 2806 f 3-Chloro-2-methyl-l-propene, 1548 2-Chloromethylthiophene, 1836 A-Chloro-3-morpholinone, 1485 /V- C h I o ro -4 - n i t ro a n i I i n e, 2224 2-Chloro-5-nitrobenzaldehyde, 2645 2-Chloro-6-nitrobenzaldehyde, 2646... 

Irradiation of 3-chloro-2-phenethyl-1 -isoquinolinone (203) in methanol afforded 8-oxo-protoberberine (205) in 56% yield591. A solvent-caged biradical (204) formed by homolytic fission of the C—Cl bond is proposed as intermediate (equation 148). In support of this, irradiation of 3-chloro-2-methyl-l-isoquinolinone in benzene results in the formation of 2-methyl-3-phenyl-l -isoquinolinone in 79% yield, though a much longer reaction time was needed than for the intramolecular reaction. When 203 was irradiated in... 

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