Methyl chloro form

OCH3 6-Methoxy-3-meth-oxycarbonyl-2-methyl-5-nitro-... 76 180-182 (Chloro- form/ Hexan) ... 

Temper- ature °C Chloro- form Methyl acetate Ethyl acetate Cyclo- hexa- none Nitro- benzene Pyridine Mesityl oxide... 

LXVI 6-Acetamido- 3-methyl- capronsaure- methylamid 10 20- 2 2 200,3 Chloro- form 0,46 25 589 +24,57... 

LXXXI (+)(R)-6-Meth- oxy-4-methyl- hexanal-di- athylacetal c12h26o3 218,3 Chloro- form 0,0962 25 589 +3,78 ... 

LXXVIII a (R)-3,7-Di- methyl- octanal-di- vinylacetal l34h26u2 226,4 Chloro- form 10,703 26 589 + 3,04 ... 

The sodium salt of enamine 8 is formed by deprotonation with NaHMDS followed by selective TV-protection with methyl chloro-formate at -78 °C to give carbamate 9 in 52-60 % yield. 

PEIs were synthesised from pyromellitic anhydride and CO-aminoacids, condensed first to form a di-acid (13) and subsequently reacted with a range of mes-ogen forming diols, e.g. 4,4 -biphenyldiol, 2,6-dihydroxynaphthalene, methyl-, chloro- and phenylhydroquinone. None of the polymers were found to contain a liquid crystal phase [27]. 

Reaction diagrams are considered especially for the circumstance of progressive substitution (or addition) on a fixed molecular skeleton, and it is noted that these naturally form Hasse diagrams for a partially ordered set (or poset) of the substituted structures. The possibility that different properties are similarly ordered is a further natural consideration, and is here illustrated for several different properties for (methyl chloro) substituted benzenes. 

Addition of Alkyl Groups. Katrizky reported that in the presence of bismuth(lll) chloride-metallic aluminum, alkyl (as well as allyl) halides react with A-(alkylamino)benzotriazoles at 20°C in THF-water to give the corresponding homoalkylated amines in high yields (Eq. 11.48). Competitive addition of CCI3 anions to N-alkyl-pyridinium salts was studied in a two-phase system of chloro-form/concentrated aqueous NaOH and in a homogeneous medium. Aminomethylation of 1-alkylpyrroles by aqueous formaldehyde and dimethylamine hydrochloride, followed by reaction with iodomethane, affords the l-alkyl-2,5- A[(trimethylammonio)methyl]pyrrole diiodide... 

Figure 3.13. An example of bonds ambiguity at the same azeotropes and components boiling temperatures for methyl-ethyl ketone(l)-benzene(2)-chloro-form(3) mixture. Arrows, directions of residium curves.

The process of chlorination takes place in a stepwise manner, methyl chloro-formate being formed first and then, successively, the monochloro-, dichloro-, and trichloromethyl chloroformates. Methyl formate reacts readily with chlorine in the dark, giving methyl chloroformate. Further chlorination in the dark without the aid of a catalyst gives some chloromethyl chloroformate, but the reaction is slow and the yield is poor. Complete conversion can only be achieved by photochlorination at near the boiling point of the liquid [51, 70]. 

Also obtained by oxidation of 6-chloro-5-methyl-2,3-diphenylbenzofuran with chromium trioxide in boiling acetic acid for 2 h, followed by saponification of the 2-(benzoyloxy)-4-chloro-5-methyl-benzophenone formed with 2 N sodium hydroxide in boiling ethanol for 15 min [515]. 

Cacchi etal. developed a novel Cul-catalyzed construction of the 2-quinolones from 3,3-diarylacrylamides via an intramolecular C-H functionalization/C-N bond-forming process (Scheme 8.95). High selectivity was observed for unsym-metrical 3,3-diarylacrylamides through using substrates where one aromatic ring bears o-methyl, chloro, or bromo substituents [167]. 

P. Cieplak, J. Caldwell, and P. Kollman,/. Comput. Chem., 22(10), 1048-1057 (2001). Molecular Mechanical Models for Organic and Biological Systems Going Beyond the Atom Centered Two Body Additive Approximation Aqueous Solution Free Energies of Methanol and N-Methyl Acetamide, Nucleic Acid Base, and Amide Hydrogen Bonding and Chloro-form/Water Partition Coefficients of the Nucleic Acid Bases. 

CH2 CH C CH. Colourless gas with a sweet odour b.p. 5°C. Manufactured by the controlled low-temperature telomerization of ethyne in the presence of an aqueous solution of CuCI and NH Cl. Reduced by hydrogen to butadiene and, finally, butane. Reacts with water in the presence of HgSO to give methyl vinyl ketone. Forms salts. Forms 2-chloro-butadiene (chloroprene) with hydrochloric acid and certain metallic chlorides. 

A mixture of 0.10 mol of freshly distilled 3-methyl-3-chloro-l-butyne (see Chapter VIII-3, Exp. 5) and 170 ml of dry diethyl ether was cooled to -100°C and 0.10 mol of butyllithium in about 70 ml of hexane was added at this temperature in 10 min. Five minutes later 0.10 mol of dimethyl disulfide was introduced within 1 min with cooling betv/een -100 and -90°C. The cooling bath vjas subsequently removed and the temperature was allowed to rise. Above -25°C the clear light--brown solution became turbid and later a white precipitate was formed. When the temperature had reached lO C, the reaction mixture was hydrolyzed by addition of 200 ml of water. The organic layer and one ethereal extract were dried over potassium carbonate and subsequently concentrated in a water-pump vacuum (bath... 

The same two alcohols are formed m the hydrolysis of 1 chloro 3 methyl 2 butene... 

The carbocation formed on ionization of 1 chloro 3 methyl 2 butene is the same allylic carbocation as the one formed on ionization of 3 chloro 3 methyl 1 butene and gives the same mixture of products... 

Bromination of isoprene using Br2 at —5 ° C in chloroform yields only /n j -l,4-dibromo-2-methyl-2-butene (59). Dry hydrogen chloride reacts with one-third excess of isoprene at —15 ° C to form the 1,2-addition product, 2-chloro-2-methyl-3-butene (60). When an equimolar amount of HCl is used, the principal product is the 1,4-addition product, l-chloro-3-methyl-2-butene (61). The mechanism of addition is essentially all 1,2 with a subsequent isomerization step which is catalyzed by HCl and is responsible for the formation of the 1,4-product (60). The 3,4-product, 3-bromo-2-methyl-1-butene, is obtained by the reaction of isoprene with 50% HBr in the presence of cuprous bromide (59). Isoprene reacts with the reactive halogen of 3-chlorocyclopentene (62). 

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