Cyclohexanone, 2-chloro-2-methyl

Methyl-2-(l-methyl-1-phenylethyl)cyclohexanone, (2S.5R)- Cyclohexanone, 5-methyl-2-(l-methyl-l-phenylethyl-, (2S-cis)- (65337-06-6), 65, 203 5-Methyl-2-(l-methyl-l-phenylethyl)cyclohexyl chloroacetate, (1R,2S,5R)- Acetic acid, chloro-, 5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl ester, [lR-(la,Z0,5a)]- (71804-27-8), 65, 203 5-Methyl-2-[l-methyl-l-(phenylmethylthio)ethyl]cyclohexanone, cis- and trans 65, 215... 

The only published method for producing pure 2-chloro-2-methyl-cyclohexanone is by the action of sulfuryl chloride on 2-methylcyclo-licxanone.3 Direct chlorination gives mixtures of the 2- and 6-chloro compounds.3... 

AI3-00040, see Cyclohexanol AI3-00041, see Cyclohexanone AI3-00045, see Diacetone alcohol AI3-00046, see Isophorone AI3-00050, see 1,4-Dichlorobenzene AI3-00052, see Trichloroethylene AI3-00053, see 1,2-Dichlorobenzene AI3-00054, see Acrylonitrile AI3-00072, see Hydroquinone AI3-00075, see p-Chloro-rrr-cresol AI3-00078, see 2,4-Dichlorophenol AI3-00085, see 1-Naphthylamine AI3-00100, see Nitroethane AI3-00105, see Anthracene AI3-00109, see 2-Nitropropane AI3-00111, see Nitromethane AI3-00118, see ferf-Butylbenzene AI3-00119, see Butylbenzene AI3-00121, see sec-Butylbenzene AI3-00124, see 4-Aminobiphenyl AI3-00128, see Acenaphthene AI3-00134, see Pentachlorophenol AI3-00137, see 2-Methylphenol AI3-00140, see Benzidine AI3-00142, see 2,4,6-Trichlorophenol AI3-00150, see 4-Methylphenol AI3-00154, see 4,6-Dinitro-o-cresol AI3-00262, see Dimethyl phthalate AI3-00278, see Naphthalene AI3-00283, see Di-rj-butyl phthalate AI3-00327, see Acetonitrile AI3-00329, see Diethyl phthalate AI3-00399, see Tributyl phosphate AI3-00404, see Ethyl acetate AI3-00405, see 1-Butanol AI3-00406, see Butyl acetate AI3-00407, see Ethyl formate AI3-00408, see Methyl formate AI3-00409, see Methanol AI3-00520, see Tri-ocresyl phosphate AI3-00576, see Isoamyl acetate AI3-00633, see Hexachloroethane AI3-00635, see 4-Nitrobiphenyl AI3-00698, see IV-Nitrosodiphenylamine AI3-00710, see p-Phenylenediamine AI3-00749, see Phenyl ether AI3-00790, see Phenanthrene AI3-00808, see Benzene AI3-00867, see Chrysene AI3-00987, see Thiram AI3-01021, see 4-Chlorophenyl phenyl ether AI3-01055, see 1.4-Dioxane AI3-01171, see Furfuryl alcohol AI3-01229, see 4-Methyl-2-pentanone AI3-01230, see 2-Heptanone AI3-01231, see Morpholine AI3-01236, see 2-Ethoxyethanol AI3-01238, see Acetone AI3-01239, see Nitrobenzene AI3-01240, see I idine AI3-01256, see Decahydronaphthalene AI3-01288, see ferf-Butyl alcohol AI3-01445, see Bis(2-chloroethoxy)methane AI3-01501, see 2,4-Toluene diisocyanate AI3-01506, see p,p -DDT AI3-01535, see 2,4-Dinitrophenol AI3-01537, see 2-Chloronaphthalene... 

S 5-isopropyl-2-chloro-2-(3-methyl-2-buteny )cyclohexanone(,i yield 47% d.r. (cisitrans) 83 17... 

Chemicals and Standard Solutions. Cyclohexanone, cyclohexanol, 1,3,5-trichlorobenzene, 1,2,4-trichlorobenzene, phenol, 4-methylphenol, 4-chloro-phenol, 1,2,3,4-tetrahydroisoquinoline, 1-chlorohexane, 1-chlorododecane, and 1-chlorooctadecane were obtained from Aldrich. Acetone, tetrahydrofuran, ethyl acetate, toluene, dimethyl sulfoxide, and methanol were obtained from J. T. Baker. Distilled-in-glass isooctane, methylene chloride, ethyl ether, and pentane were obtained from Burdick and Jackson. Analytical standard kits from Analabs provided methyl ethyl ketone, isopropyl alcohol, ethanol, methyl isobutyl ketone, tetrachloroethylene, dodecane, dimethylformamide, 1,2-dichlorobenzene, 1-octanol, nitrobenzene, 2,4-dichlorophenol, and 2,5-dichlorophenol. All chemicals obtained from the vendors were of the highest purity available and were used without further purification. High-purity water... 

A six-membered nitrogen-sulfur heterocycle, namely, a 2,3-dihydro-2-imino-4//-benzo[e thiazin-4-one, is produced on reaction of methyl 2-chloro-3,5-dinitrobenzoatc with thiourea in basic medium 373 furthermore, a tetrahydrospirobenzothiazine 213 is formed in addition to its hexahydrospiroquinazoline analog on interaction of cyclohexanone with thiourea in hydrochloric acid.329... 

This microflow processing was also demonstrated using other P-keto esters such as ethyl 2-chloro-3-oxobutanoate [309,273] or ethyl 2-methyl-3-oxobutanoate [273]. Five-and six-ring P-ketoester derivatives such as 3-acetyl-3,4,5-trihydrofuran-2-one (1) [273], 2-acetyl cyclohexanone [273] and ethyl 2-oxocydohexane carboxylate (2) [273] were directly fluorinated as well. 

Draw the structural formula for (2.R,3.R,4R)-3-chloro-4-isopropyl-2-methyl-cyclohexanone in its chair form with the lowest energy. 

Alkylation of cyclohexanone enamines with methyl chloro(methoxy)acetate, followed by alkaline hydrolysis, affords the y-keto acid 30, which readily cyclizes to the unsaturated lactone 31 on treatment with hydrogen chloride in acetic acid (equation 20)40. 

Favorskil rearrangement of 2-chloro-cyclohexanone, 39, 37 Ferric chloride, 36, 31 37, 77 Ferric nitrate hydrate, 39, 73 Ferrocene, 36, 31, 34 Ferrous chloride solution in tetrahy-drofuran, 36, 31, 34 Fischer indole synthesis, of 1,2-benzo-3,4-dihydrocarbazole, 30, 91 of 1,2,3,4-tetrahydrocarbazole, 30, 90 Flavone, 32, 72 Flavylium chloride, 32, 75 Flow meter, 34, 7 Fluorene, 34, 32 39, 44 Fluorene, 9-methyl-, 39, 43 9-Fluorenecarboxylic acid, 33, 37 o-Fluorobromobenzene, 39, 75... 

The reaction of 2-chloro-2-methylcyclohexanone with dimethyl sodiomalonate carried out at ice-bath temperature did not give the expected l-methylbicyclo[3.1.0]hexane derivative 24 (R = Me) but afforded only the substitution products 25 and 26 (R = Me) as a 52 48 mixture in 50% yield. The reaction with diethyl sodiomalonate likewise afforded a 27 73 mixture of the corresponding esters 25 and 26 (R = Et) in 43% yield. These results have been explained by the occurrence of a zwitterionic intermediate. By contrast, reaction of 2-chloro-4-methy 1-cyclohexanone with diethyl sodiomalonate under similar conditions gave 6-[bis(ethoxycar-bonyl]-3-methylbicyclo[3.1.0]hexan-6-ol (27) in 59% yield. This compound was tentatively assigned to have a more preferable boatlike conformation, which allows the bulky diester moiety to take the more favorable equatorial orientation. In a similar way, a 44 56 mixture of cn(/u-2-methyl- and exo-2-methyl-6-[bis(ethoxycarbonyl)methyl]-2-methylbicyclo-[3.1.0]hexan-6-ol (28) was obtained from the reaction of 2-chloro-5-methylcyclohexanone and diethyl sodiomalonate in 49% yield. 

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