5 -Chloro-3 -methyl-1 -phenethyl

Irradiation of 3-chloro-2-phenethyl-1 -isoquinolinone (203) in methanol afforded 8-oxo-protoberberine (205) in 56% yield591. A solvent-caged biradical (204) formed by homolytic fission of the C—Cl bond is proposed as intermediate (equation 148). In support of this, irradiation of 3-chloro-2-methyl-l-isoquinolinone in benzene results in the formation of 2-methyl-3-phenyl-l -isoquinolinone in 79% yield, though a much longer reaction time was needed than for the intramolecular reaction. When 203 was irradiated in... 

INDOLE, 3-(2-AMIN0PR0PYL) -6-CHLORO-, HYDROCHLORIDE INDOLE, 5-AMINO-3-(l-PYRROLIDINYLMETHYL)-INDOLE, 5-NETHOXY-3-)l-PHENETHYL- -PIPERIDYL)METHYL-INDOLE, 3- ( 3-piperidylmethyl)-INDOLE, 5-(DIMETHYLAMINO)-... 

INDOLE, l-METHYL-3-(ll-PIPERIDYLMETHYL)-, HYDROCHLORIDE INDOLE, 3- (2-AMINOPROPYL)-ft-CHLORO-, HYDROCHLORIDE INDOLE, 2-(2-AMINOBUTYL)- -CHLORO-, HYDROCHLORIDE INDOLE, 3 (2-AMINOBUTYL)-6-CHLORO-, HYDROCHLORIDE INDOLE, 3-((DIMETHYLAMINO)METHYL)-7-NITRO-INDOLE, 3-(2-(HYDROXYAMINO)PROPYL)-, HYDROCHLORIDE, ( -)-INDOLE, 3-(2-AMINOETHYL)-5-METH0XY-, HYDROCHLORIDE INDOLE, 5-METHOXY-3- ( -PIPERIDYLMETHYL) -INDOLE, 3 (l-PHENETHYL- t-PIPERIDYLMETHYL) -... 

SYNS BENZENESULFONAMIDE, N-(3-CHLORO-2-OXO-l-(PHENYLMETHYL)PROPYL)-4-METHYL-.(S)- 1-N-(a-(CHLOROACETYL)PHENETHYL)-p-TOLUENE-SULFONAMIDE p-TOLUENESULFONAMIDE, N-(a-(CHLOROACETYL)PHENETHYL)-, (-)-... 

Other selected examples are summarized in Table 1-10. In addition to aldehydes, both cyclic and acyclic ketones can be reduced equally well. jf c-Phenethyl alcohol (59, R=Ph) as hydride source works more effectively than i-PrOH. Based on this finding, the asymmetric MPV reduction of unsymmetrical ketones [63] with chiral alcohol in the presence of catalyst 58 was examined. Treatment of 2-chloroacetophenone (60) with optically pure (f )-(-t-)-sec-phenethyl alcohol (1 equiv) under the influence of catalytic 58 afforded (5)-(-t)-2-chloro-1 -phenyletha-nol (61) with moderate asymmetric induction (82%, 54% ee). Switching chiral alcohols from (/ )-(-f)-sec-phenethyl alcohol to (/ )-(-i-)-a-methyl-2-naphthalene-methanol and (f )-(-H)- fcc-o-bromophenethyl alcohol further enhanced the optical yields of 61 in 70 and 82% ee, respectively [62]. 

R)-m-[(E)-2- 7-Chloro-2-quinolyl)vinyl]-a-[o-(1-hydtoxy-1-methylethyl)phenethyl]benzyl]thio]methyl]-cyclopropane acetic acid. Montelukast. Selective leukotriene 04 receptor antagonist. Used as an antiasthmatic. Merck Co.Inc. 

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