Chloro methyl benzyl ether

Chloro-3-hydrox34oluene, see p-Chloro-ro-cresol 2-Chloroisopropyl ether, see Bis(2-chloroisopropyl) ether p-Chloroisopropyl ether, see Bis(2-chloroisopropyl) ether Chloromethane, see Methyl chloride (Chloromethyl)benzene, see Benzyl chloride Chloromethyl bromide, see Bromochloromethane Chloromethyl ether, see sym-Dichloromethyl ether (Chloromethyl)ethylene oxide, see Epichlorohydrin (2-Chloro-l-methylethyl) ether, see Bis(2-chloroisoprop-yl)... 

The above iodides have been used as 1 -labelled building blocks in the preparations of [3-nC]tyrosine, (9-methyl[3-nC]tyrosine, /7-chloro[3-nC]phenylalanine and / -fluoro[3-JlC]phenylalanine by alkylations of glycine derivatives241. The [nC]ethyl ether derivatives (using sodium ethoxide as nucleophile) and 3-nitrophenyl-4-methoxy[(Z-nC]benzyl ether (using sodium 3-nitrophenolate) have been synthesized also, employing 4-methoxy(ar-14C)benzyl iodide 18324. ... 

Heptakis 6-0-t-butyldimethylsilyl-P-cyclodextrin, on reaction with 4-chloro-methyl-A -methyl-2-nitroaniline, affords the mono-3-substituted benzyl ether. P-Cyclodextrin carrying a 2-(naphthylmethyl) group at 0-6 exists with the aromatic rings within the cavity to an extent which is very temperature dependent. Temperature can therefore be used to control the degree of complexing of the aromatic system with a fluorescent naphthalene compound. Heptakis-[2,3-di-0-acetyl-6-deoxy-6-iodo]-P-cyclodextrin treated with 6-methoxycarbonyl-2-naphthol allowed access to the compound having naphthoic acid substituents at all of the primary positions, and this forms a very stable 1 1 complex with a merocyanine laser dye which is a mimic of the antenna function in photosynthesis and shows promise as a photochemical microreactor. Mono-[6-0-(8-qui-nolyl)]-P-cyclodextrin has been reported, and the stabilities of inclusion complexes with amino acid guests have been described. ... 

Model compounds of high ortho-ortho resoles have been prepared by Kammerer et al from the condensation of p-chloro-substituted phenols followed by subsequent dehalogenation. They also prepared a series of p-methyl-substituted benzylic ether-containing compounds and analyzed their structures by IR and UV. 

The second order nature of quaternization reactions in our system was confirmed by rate studies on model compounds. Although benzyl chloride is usually selected as the model for chloro-methylated polymers , we chose to synthesize a difunctional model that would be sensitive to neighboring group effects. Condensation of 4-chlorophenyl phenyl sulfone with the disodlum salt of bis-phenol-A yielded an excellent model for the polysulfone segment, Quantitative chloromethylation of with a chloromethyl methyl ether/ methyl acetate mixture in the presence of stannic chloride afforded the corresponding bischloromethyl adduct,... 

Preparation by hydrogenolysis of 6-(benzyloxy)-3,3 -dichloro-2,4,4, 6 -tetramethoxy-2 -methyl-benzo-phenone (SM) under hydrogen in the presence of 10% Pd/C at 25°. SM was obtained by condensation of 3-chloro-4,6-dimethoxy-2-methyl-benzoic acid with 4-chloro-3, 5-dimethoxyphenol benzyl ether in the presence of trifluo-roacetic anhydride in methylene under nitrogen for 80 min (50%) [1179]. m.p. 196-197° [1179] H NMR [1179], IR [1179], MS [1179]. 

Related Reagents. Benzyl Chloromethyl Ether Benzyl Chloromethyl Sulfide r-Butyl Chloromethyl Ether 2-Chloro-ethyl Chloromethyl Ether Chloromethyl Methyl Sulfide Dimethoxymethane (p-Methoxybenzyloxy)methyl Chloride 2-Methoxyethoxymethyl Chloride 2-(Trimethylsilyl)ethoxymethyl Chloride. 

Both methyltriethylphosphonium fluoride and methyltributylphospho-nium fluoride have been prepared The latter generates benzyl fluoride from benzyl chloride in 80% yield and ethyl fluoroacetate from ethyl bromoacetate in 53% yield Methyltnbutylphosphonium fluoride converts 1-bromododecane to a 50 50 mixture of 1-fluorododecane and 1-dodecene Methyltnbutylphosphonium fluoride also quantitatively forms styrene from 1-bromo-1-phenylethane [26] Methyl-tnbutylphosphonium fluonde is the reagent of choice for the conversion of N,N dimethylchloroacetamide to its fluoride, but it is not able to convert chloro-acetonitnle to fluoroacetomtrile Methyltnbutylphosphonium fluoride changes chloromethyl octyl ether to the crude fluoromethyl ether in 66% yield The stereoselectivity of methyltnbutylphosphonium fluoride is illustrated by the reac tions of the 2-tert-butyl-3-chlorooxiranes [27] (Table 2)... 

The enantiomerically pure l-[(benzyl(dimethyl)silyl)methyl]pyrrolidine, obtained from ben-zyl(chloro)(dimethyl)silane and (5,)-2-(methoxymethyl)pyrrolidine , afforded after deprotonation and subsequent alkylation the diastereomerically pure (by NMR spectroscopy) (a-alkylben-zyl)silanes2. To obtain this high degree of diastereoselectivity, the alkylation had to be performed in the weakly complexing solvent diethyl ether. In THF a diastereomeric ratio of only 3 1 was found with iodomethane as alkylating agent. 

Benzylchlorobis(triphenylphosphine)-, trans- Palladium, benzylchlorobis-(triphenylphosphine)-, trans- Palladium, chloro(phenylmethyl)bis(tri-phenylphosphine)-, (SP-4-3)- (22784-59-4), 67, 86 ( )-Benzyl 2,3-epoxypropyl ether Oxirane, [(phenylmethoxy)methyl]- ... 

A 2-(trimethylsilyl)ethyl glycoside is convertible into a glycosyl chloride by treatment with 1,1-dichloromethyl methyl ether in the presence of zinc(II) chloride, tin(IV) chloride, or iron(III) chloride. Normally an a-chloro sugar is the product. If a (3-chloro product is formed first (kinetic product) by participation from a 2-O-substituent, this is rapidly equilibrated into the thermodynamically more stable a product (anomeric effect, Section VI). The transformation is compatible with acetyl, benzoyl, and benzyl protecting groups and most importandy, also with the presence of inter-residue glycosidic bonds 229,230... 

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