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Methyl 6-chloro-2-pyrazinecarboxylate

Methyl 3-oxo-3,4-dihydro-2-pyrazinecarboxylate (22) gave methyl 3-chloro-2-pyrazinecarboxylate (23) (S02C1, trace Me2NCHO, PhMe, 80°C, N2, 3 h 80%) 54 the isomeric substrate, methyl 5-oxo-4,5-dihydro-2-pyrazinecarboxy-late, gave methyl 5-chloro-2-pyrazinecarboxylate (24, R = H) (neat POCl3, trace Me2NCHO, reflux, 2 h 68%) 85 and the homologous methyl 5-chloro-6-methyl-2-pyrazinecarboxylate (24, R = Me) (77%) was made similarly.85... [Pg.141]

Chloro-5-methylpyrazine 2-Chloro-6-methylpyrazine 6-Chloro-A,-methyl-2-pyrazinecarboxamidine 6-Chloro-5-methyl-2-pyrazinecarboxylic acid 5-Chloro-6-methyl-2-pyrazinecarboxylic acid 1-oxide... [Pg.393]

Ethyl 3-amino- l-benzyl-5-isobutyl-6-oxo-1,6-dihydro-2-pyrazinecarboxylate 4-oxide Ethyl 3-amino-6-benzyloxy-5-isobutyl-2-pyrazinecarboxylate 4-oxide Ethyl 3-amino-6-chloro-5-ethoxy-2-pyrazinecarboxylate Ethyl 6-amino-3-chloromethyl-5-cyano-2-pyrazinecarboxylate Ethyl 6-amino-3-chloromethyl-5-cyano-2-pyrazinecarboxylate 1-oxide Ethyl 3-amino-5-chloro-6-methyl-2-pyrazinecarboxylate Ethyl 3-amino-5-chloro-6-phenyl-2-pyrazinecarboxylate Ethyl 5-amino-6-cyano-3-methyl-2-pyrazinecarboxylate Ethyl 6-amino-5-cyano-3-methyl-2-pyrazinecarboxylate Ethyl 6-amino-5-cyano-3-methyl-2-pyrazinecarboxylate 1-oxide Ethyl 3-amino-5,6-dimethyl-2-pyrazinecarboxylate 5-Ethylamino-6-ethylcarbamoyl-3-methylami no-2-pyrazinecarboxamide... [Pg.419]

Methyl 3-chloroformyl-2-pyrazinecarboxylate Methyl 6-chloro-5-methoxy-3-oxo-3,4-dihydro-2-pyrazinecarboxylate Methyl 6-chloro-3-methoxy-2-pyrazinecarboxylate Methyl 3-chloro-5-methyl-2-pyrazinecarboxylate Methyl 5-chloro-6-methyl-2-pyrazinecarboxylate Methyl 5-chloro-6-methyl-2-pyrazinecarboxylate 1-oxide Methyl 6-chloro-3-nitro-2-pyrazinecarboxylate Methyl 6-chloro-3-oxo-3,4-dihdyro-2-pyrazinecarboxylate... [Pg.444]

Propyl 5-chloro-2-pyrazinecarboxylate Propyl 5-methyl-2-pyrazinecarboxylate Propyl 3-propoxy-2-pyrazinecarboximidate Propyl 3-propoxy-2-pyrazinecarboxylate... [Pg.454]

Methyl 6-benzyloxy-3-chloro-5-isobutyl-2-pyrazinecarboxylate 4-oxide (134, R = Cl) gave methyl 6-benzyloxy-5-isobutyl-3-methoxy-2-pyrazinecar-boxylate 4-oxide (134, R = OMe) (MeONa, MeOH, 20°C, 30 min 71%).337... [Pg.164]

Methyl 6-chloro-2-pyrazinecarboxylate 4-oxide gave methyl 6-thioxo-l,6-dihy-dro-2-pyrazinecarboxylate 4-oxide (138) (NaHS, EtOH, 20°C, 3 h 46%).89 2-Chloropyrazine gave 2( l//)-pyrazincthione [NaHS/MeOH (made in situ), reflux, 1 h 91%].1602... [Pg.165]

Methyl 3-chloro-2-pyrazinecarboxylate (173, R = Cl) gave methyl 3-azido-2-pyrazinecarboxylate (173, R = N3) (NaN3, Me2NCHO, 120°C, N2, 1 h ... [Pg.171]

Methyl 3-bromo-6-chloro-5-(4-methylpiperazin-l-yl)-2-pyrazinecarboxylate (177) gave methyl 6-chloro-5-(4-methylpiperazin-l-yl)-2-pyrazinecarboxy-late (178) (H2, Pd/C, THF, 20°C, 2 days 70% note selective debromination and intramolecular supply of the base).645... [Pg.172]

Methyl 3-amino-6-chloro-5-ethoxalyl-2-pyrazinecarboxylate oxime (56) gave 3-amino-5-(a-amino-a-ethoxycarbonylmethyl)-6-chloro-2-pyrazinecarboxylate (57) [Rh/C, H2 (2 atm), AcONH4, AcOH—EtOH, 20°C, 2.5 h 70%].808 Also other examples.683... [Pg.268]

Methoxy- 2(1 77)-pyrazinethione 3 -Methoxy- 2(1 77)-pyrazinone 6-Methoxy-2(177)-pyrazinone 2-Methoxy-3-trimethylsilylpyrazine Methyl 6-acetamido-2-pyrazinecarboxylate Methyl 3-acetoxy-2-pyrazinecarboxylate Methyl 5-acetoxy-2-pyrazinecarboxylate Methyl 6-acetoxy-2-pyrazinecarboxylate Methyl 5-acetyl-3-amino-2-pyrazinecarboxylate Methyl 6-acetyl-3,5-diamino-2-pyrazinecarboxylate Methyl 5-allylamino-3-amino-6-chloro-2-pyrazinecarboxylate... [Pg.438]

Methyl 3-allylamino-6-chloro-5-ethylamino-2-pyrazinecarboxylate 3 - (2-Methylallyl)- 5,6-diphenyl-... [Pg.438]

Methyl 5- (A-allyl-A-ethylamino)-3-amino-6-chloro-2-pyrazinecarboxylate Methyl 5-(iV-allyl-iV-methylamino)-... [Pg.438]

Methyl 3-amino-5-anilino-2-pyrazinecarboxylate Methyl 3-amino-5-benzoyl-6-bromo-2-pyrazinecarboxylate Methyl 3-amino-5-benzoyl-2-pyrazinecarboxylate Methyl 3-amino-5-benzylamino-6-chloro-2-pyrazinecarboxylate Methyl 3-amino-5-benzylamino-2-pyrazinecarboxylate Methyl 3-amino-6-benzyloxy-5-isobutyl-2-pyrazinecarboxylate 4-oxide Methyl 3-amino-6-bromo-5-chloro-2-pyrazinecarboxylate Methyl 3-amino-6-bromo-5-diethylamino-2-pyrazinecarboxylate... [Pg.438]

Methyl 3-amino-6-bromo-2-pyrazinecarboxylate Methyl 3-amino-6-bromo-2-pyrazinecarboxylate 4-oxide Methyl 3-amino-5-butylamino-6-chloro-2-pyrazinecarboxylate... [Pg.438]

Methyl 3-amino-5-(fV-butyl-fV-ethylamino)-6-chloro-2-pyrazinecarboxylate — (H 426)... [Pg.439]

Methyl 3-amino-6-chloro-5-(cyclopropylmethyl)amino-2-pyrazinecarboxylate (H 427)... [Pg.439]

Methyl 3 - amino- 6- chloro- 5 - (N- ethy 1-N-isopropylamino)-2-pyrazinecarboxylate — (H 428)... [Pg.439]

See other pages where Methyl 6-chloro-2-pyrazinecarboxylate is mentioned: [Pg.319]    [Pg.440]    [Pg.444]    [Pg.444]    [Pg.102]    [Pg.147]    [Pg.147]    [Pg.157]    [Pg.260]    [Pg.354]    [Pg.438]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]    [Pg.439]   
See also in sourсe #XX -- [ Pg.172 ]

See also in sourсe #XX -- [ Pg.172 ]



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2-pyrazinecarboxylate

3-chloro-2-methyl

Chloro methylation

Methyl 2-pyrazinecarboxylate

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