4-Chloro-2-methyl-1 -phthalazinone

Hydroxyethyl)-3-methyl-l,4(2//,3/l)-phthalazinedione (27, R = OH) gave 2-(2-chloroethyl)-8-methyl-l,4(2//,3/l)-phthalazinedione (27, R = Cl) (SOCI2, CHCI3, reflux, 16 h 75%) " likewise, 7-hydroxymethyl- gave 7-chloro-methyl-2-phenyl-l(2//)-phthalazinone (neat SOCI2, reflux, 1 h 78%)." "... 

Amino-6-chloro-3-hydroxy-l-isoindolinone (259) with hydrazine gave 6-amino-7-chloro-l(2//)-phthalazinone (260, R = H) (H2O, 95°C, N2, 2h 77%) or with methylhydrazine gave 6-amino-7-chloro-2-methyl-l(277)-phthalazinone (260, R = Me) (H2O, 90°C, 3 h 60%) analogs likewise. " ... 

Methyl-1,4(277,37/)-phthalazinedione (9) gave 4-chloro-2-methyl-1(277)-phthalazinone (10) (POCI3, reflux, 2h % note the immunity of the nontautomeric 0x0 substituent to halogenolysis). ... 

Dihydro-l(2/i)-phthalazinone (81) with 3-chloro-3-diethylaminomethacry-loyl chloride (82) gave 3-diethylamino-2-methyl-5,10-dihydro-l//-pyra-zolo[l,2-fe]phthalazine-l,5-dione (83) (substrate, EtsN, PhMe, 0°C synthon in PhMeJ, during 30 min then 20°C, 2 h 81%) analogs likewise. ... 

Chloromethyl-7-methoxy-1 (2H)-phthalazinone l-Chloro-4-(A -methyl-A -methylenehydrazino)phthalazine 1 -Chloro-3-methyl-4-methylimino-3, 4-dihydrophthalazine... 

Chloromethyl-4-phenyl-1 (2H)-phthalazinone 1 -Chloro-4-methyl-7-nitrophthalazine 7-Chloro-2-methyl- 1-oxo-1,2-dihydro-6-phthalazinesulfonamide 7-Chloro-3-methyl-4-oxo-3,4-dihydro-6-phthalazinesulfonamide 7-Chloro-2-methyl-1 -oxo-1,2-dihydio-6-phthalazinesulfonyl chloride... 

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