5- Chloro-l-methyl-4-nitroimidazole

Chloro-l-methyl-4-nitroimidazole (204) was also used as a heterocyclic component in the Turpin reaction. Intermediate 205 was formed under mild conditions and its cyclization was achieved by heating with ethanolic dimethylamine in a sealed tube to give a blue-colored substance, which was attributed structure 206 (Scheme 32) (52JCS784). 

Azathioprine Azathioprine, 6-[(l-methyl-4-nitroimidazol-5-yl)thio]purine (31.2.1), is synthesized by heteroarylation of the sulfhydrile group of 6-mercaptopurine (30.1.2.9) with 5-chloro-l-methyl-4-nitroimidazol in the presence of sodium acetate as a weak base [13]. 

Oxidative dimerization of the lithium derivatives of 1-substituted 4,5-dicyanoimidazoles give (71) <91JA6178>. Chromium trioxide in acetic acid converts 5-chloro-l-methyl-4-nitroimidazole into the... 

It is prepared by treating 6-mercaptopurine with 5-chloro-l-methyl-4-nitroimidazole. 

Allopurinol (ethyl ethoxymethylene cyanoacetate), 0.01% pet Azathioprine (5-chloro-l-methyl-4-nitroimidazole), 0.01% pet Bumetanide (sulfonyl benzoic acids), 1% pet Chlorodiazepoxide (2-chloromethyl-4-phenyl-6-chlorquinazoline-3-oxide), 1% pet (44 controls neg) Chloroquine (4,7-dichloroquinoline), 5% pet Clenbuterol (4-amino-(x-bromo-3,5-dichloroacetophenone), 0.5% pet... 

Jolanki R, Kanerva L, Estlander T, Tarvainen K (1994) Concomitant sensitization to triglycidyl isocyanurate, diaminodiphe-nyl methane and 2-hydroxyethyl methacrylate from silk-screen printing coatings in the manufacture of circuit boards. Contact Dermatitis 30 12-15 Jolanki R, Tarvainen K, Tatar T, Estlander T, Henriks-Eckerman M-L, Mustakallio KK, Kanerva L (1996) Occupational dermatoses from exposure to epoxy resin compounds in a ski factory. Contact Dermatitis 34 390-396 Jolanki R, Alanko K, Pfaffli P, Estlander T, Kanerva L (1997) Occupational allergic contact dermatitis from 5-chloro-i-methyl-4-nitroimidazole. Contact Dermatitis 36 53-54 Kalimo K, Jolanki R, Estlander T, Kanerva L (1989) Contact allergy to antioxidants in industrial greases. Contact Dermatitis 20 151-152... 

Jolanki R, Alanko K, Pfaffli P, Estlander T, Kanerva L (1997) Occupational allergic contact dermatitis from 5-chloro-i-methyl-4-nitroimidazole. Contact Dermatitis 36 53-54... 

N,N -Dimethyloxaldiamide is reacted with PCI5, to give 4-chloro-l-methyl imidazole. This is nitrated with HN03 to give 5-nitro-l-methyl-4-chloroimidazole. Then, a mixture of 4.6 grams of anhydrous 6-mercaptopurine, 5 grams of l-methyl-4-chloro-5-nitroimidazole and 2.5 grams of anhydrous sodium acetate in 100 ml of dry dimethyl sulfoxide was heated at 100°C for 7 hours. 

The recent development of anhydrous highly nucleophilic fluoride salts has made such nucleophilic substitutions a facile transformation. l-Methyl-5-chloro-4-nitroimidazole 108, one of the several substrates that underwent rapid nucleophilic... 

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