Isothiazole. 5-chloro-3-methyl

Chloro-4-inethylisothiazole is formed by chlorination of 4-methyl-isothiazole under the influence of irradiation, together with an equal quantity of 4-chloromethylisothiazole. Side-chain halogenation of... 

Chloromethylbenzene. See Monochlorotoluene (ChloromethyO benzene. See Benzyl chloride (ChloromethyO ethylene oxide. See Epichlorohydrin Chloromethylisothiazolinone 5-Chloro-2-methyl-4-isothiazolin-3-one 5-Chloro-2-methyl-2H-isothiazol-3-one. SeeMethylchlorolsothlazolinone Chloromethyloxirane 2-(Chloromethyl) oxirane. See Epichlorohydrin (Chloromethyl) oxirane, 4,4 -(1-methylethylidene) bisphenol copolymer. 

Chloromethylisothiazolinone 5-Chloro-2-methyl-4-isothiazolin-3-one 5-Chloro-2-methyl-2H-isothiazol-3-one. See Methylchloroisothiazolinone Chloromethylmercury. See Methyl mercury (II) chloride... 

Diehl, M. A. and Chapman, J. S., 1999. Association of the biocide 5-chloro-2-methyl-isothiazol-3-one with Pseudomonas aeruginosa and Pseudomonas fluoreseens. International Biodeterioration Biodegradation 44, 191-199. 

The mixture of 5-chloro-2-methyl-2H-isothiazol-3-one [EC No 247-500-7] and 2-methyl-2H-isothiazol-3-one [EC No 220-239-6] (3 1) ( CAS N° 55965-84-9) (II, 15.3.) is widely used for tank side preservation of water diluted coolants. The efficiency for a long term preservation is limited. The environment of a coolant contains many possibilities to inactivate these molecules. 

For example, ammonia, amines, thiols and sulphites very strongly influence efficacy, especially of the mixture of 5-chloro-2-methyl-2H-isothiazol-3-one and 2-methyl-2H-isothiazol-3-one, which can lead to loss of effect. Use in coolant concentrates is therefore ruled out from the outset. 

Already alkaline pH values lead to a rapid break down of the 5-chloro-2-methyl-2H-isothiazol-3-one (II, 15.2.)(Figure 6), which is the main active compound in that mixture. It is c. 50-times more active than the 2-methyl-2H-isothiazol-3-one (II, 15.1.). 

The formulation of 2,l-benzisothiazolin-3-one as ketonic tautomers (see Vol. 3, p. 558) has been confirmed by the preparation of its N- and O-alkylated derivatives, by unambiguous routes, and examination of their u.v. spectra. The same conclusions have been reached about 5-chloro-2,l-benzisothiazolin-3-one. Other nucleophilic displacements of the 3-halogen in 3-chloro- and 3,5-dichloro-2,1-benzisothiazole have been reported the auxin analogue (72 R = CHgCOaH) was obtained in the course of this work. The results of a comparative study of the rates of A -methylation are included under isothiazoles (p. 344). 

Synonyms Chloromethyllsolhlazollnone 5-Chloro-2-methyl-4-lsothlazolln-3-one Chloro-2-methyl-3(2H)-isothiazotone 5-Chtoro-2-melhyl-2H-isothiazol-3-one CIT ... 

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