Chloro-acetic acid methyl ester

Chloro-indole-3-acetic acid, methyl ester Pisum sativum (see 2)... 

C3H4C1F02 chloro-fluoro-acetic acid methyl ester 433-52-3... 

S-Chloro-a-methyl-l, 3,4-tetrahydrocarbazole-2-acetic acid ethyl ester... 

CN [[8-chloro-3-[2-(diethylamino)ethyl]-4-methyl-2-oxo-2ff-l-benzopyran-7-yl]oxy]acetic acid ethyl ester hydrochloride... 

Cyclohexylmethylpropiolaldehyde diethyl acetal, 39, 60 1,2-Cyclononanedione, 36, 78 Cyclopentadiene, 32, 41 36, 32, 35 Cyclopentanecarboxylic acid, METHYL ESTER, 39, 37 Cyclopentanol, 2-chloro-, irans-,... 

Chloro-benzoyl)-5-methoxy-2-methyl-1 H-indol-3-yl]-acetic acid carboxymethyl ester, C21H18CIN06, Mr 415,82, mp 150-153 °C (fine pale yellow crystals)... 

CHLORO-2-CYCLOPROPYLIDENACETIC ACID, METHYL ESTER ACETIC ACID,... 

A mixture of 34.9 g of 6-chloro-a-methyl-l,2,3,4-tetrahydrocarbazole-2-acetic acid ethyl ester (mixture of diastereomers), 350 ml CP xylene and 56.0 g of p-chloranil was stirred and heated under an atmosphere of dry nitrogen. The reaction flask was wrapped in aluminum foil in order to keep out any extraneous light. After the reaction mixture had stirred at reflux temperature for 6 hours, heating and stirring were stopped and the reaction mixture was left overnight at room temperature. The supernatant liquid was decanted... 

A mixture of 5-chloromethyl salicylate, 3-chloro-2-methylpropene, potassium carbonate, and acetone was heated at reflux overnight. After cooling, the mixture was extracted with diethyl ether and ethyl acetate. The organic extracts were combined, washed twice with a 10% sodium chloride solution and water, dried over sodium sulfate, and concentrated in vacuum. The resulting liquid was vacuumed distilled. The fraction collected and the desired 5-chloro-2-(2-methyl-2-propenyloxy)benzoic acid, methyl ester was obtained. 

A mixture of the 2-hydroxy-5-chloro-3-(2-methyl-2-propenyl)benzoic acid, methyl ester and 1 L of methanol was saturated with 90% formic acid and then refluxed overnight. The solution was concentrated in vacuum, added to water, and extracted with ethyl acetate. The organic layer was washed with water, dried over sodium sulfate, and concentrated in vacuum, providing the desired 2,2-dimethyl-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid, methyl ester as an oil. 

The zinc procedure has been extended to CF3CCI3 to form 2 chloro-l,l,l,-trifluoro-2-alkenes (84 equation 19). and a-fluoro-a,p-unsaturated carboxylic acid methyl esters (87) with methyl dichlorofluo-roacetate (8jS equation 20). Both of these transformations are carried out with zinc and acetic anhydride. Several variations of this reaction have appeared in the literature." The mechanism appears to dramatically different from the Oshima methylenation. In this case, the reaction proceeds through the alcohol intermediate, which is converted to the acetate and reductively cleaved. 

The pyrimidine part (4,5-dichloro-6-methylpyrimidine, 11) is synthesized in a two-step sequence starting with the condensation of 2-chloro-3-oxobutanoic acid methyl ester (8) and formamidine acetate 9 [15] to give 5-chloro-4-hydroxy-6-methylpyrimidine (10) in high yield, followed by the chlorination of the hydroxy group using standard synthesis methodology [15-18]. Synthesis of the sub-... 

Another important derivative of m-cresol used in the manufacture of plant protection agents is m-phenoxytoluene, which can be produced from m-cresol and chloro- or bromobenzene at temperatures of 200 °C, with copper catalysts. m-Phenoxytoluene is converted into m-phenoxybenzoic acid methyl ester by oxidation with a cobalt acetate/KBr catalyst and subsequent esterification m-phenoxybenzoic add methyl ester serves as an intermediate in the production of m-phenoxybenzaldehyde, which is used as the raw material in the production of the synthetic pyrethroid insecticide, fenvalerate (see Chapter 6.3.2). The cyanohydrin is formed in-situ, then made to react with 2-isopropyl-(4-chlorophenyl) acetic acid chloride to yield fenvalerate, which was developed by Sumitomo Chemical in 1972. Pyrethroid insecticides are distinguished by their low toxicity and high activity. 

CDX-026 (9.2 kg) and the cofactor NADP-Na (0.23 kg) were added to the reaction mixture and the reaction was carried out at 40-45°C under stirring for 40-45 h. At the end of the reaction, saturated NaCi soiution (4 voi) and ethyi acetate (10 voi) were added to the reaction mixture. The enzyme was fiitered at 60-70°C using a pressure nutsche. The organic phase containing the product was separated. The aqueous iayer was extracted with ethyi acetate (2 voi), and the organic phase was combined with the product layer. The combined organic phase was dried and concentrated to give the crude (S)-2-[3-2[7-chloro-2-quinolinyl]ethenyl]phenyl-3-hydroxypropyl]benzoic acid methyl ester 64. The crude product was purified by recrystallisation from 70% aqueous methanol (14 voi) to get pure product 64 as monohydrate 3 (233 kg), 97.2% yield, >99.9% ee [125,126]. 

Acetic acid, (4-chloro-2-oxobenzothiazolin-3-yl)- — see Benazolin Acetic acid, cyano-methyl ester... 

B) Preparation of 7-Chloro-3-Methoxycarbony/-5-Phenyl-2-0xo-2,3-Dihydro-iH-Benzo [fl-1,4-Diazepine (4347 CB) A solution of 9.2 g (0.04 mol) of compound 4356 CB in 20 ml of methanol is added dropwise, in the course of one hour and 30 minutes, to a boiling solution of 9.2 g (0.05 mol) of the hydrochloride of methyl aminomalonate in 30 ml of methanol. When this is completed, heating under reflux is continued for 30 minutes and the product then concentrated to dryness under reduced pressure. The residue is taken up in water and ether, the ethereal layer separated, the product washed with water and dried over sodium sulfate. The solvent is evaporated under reduced pressure. The residue, which consists of the methyl ester, could not be obtained in the crystalline state. It is dissolved in 25 ml of acetic acid, heated under reflux for 15 minutes, the product evaporated to dryness and the residual oil taken up in ether. A colorless solid separates which... 

Phosphoryl chloride [10025-87-3], 4 Phthalamic acid, A V-diethyl-, methyl ester [2659344-2],63 Piperidine [110-894], 86, 118 acetate [4540-334], 118 Piperidine, 1 chloro- [2156-71-0], 118 Potassium cyanide [151-50-8], 20... 

Acetic acid, anhydride, [108-24-7], 58,157 bromo-, methyl ester [96-32-2], 57, 60 chloro-, 1,1-dimethylethyl ester, 55, 94 cyano-, ethyl ester [105-56-6], 55, 58,... 

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