Methallyl chloride

The checkers obtained a heavy slurry at this stage which became heavier during addition of methallyl chloride. They found it necessary to dilute with more tetrahydrofuran (about 450 ml. for the scale given in the procedure) before methallyl chloride was added. 

Chloro-2-methylpropene (methallyl chloride) is available from Fluka A G and Eastman Organic Chemicals. The chloride, b.p. 72° (760 mm.), was distilled before use. 

Chemical Designations - Synonyms gamma-Chloroisobutylene 3-Chloro-2-methylpropene beta-Methallyl chloride beta-Methylallyl chloride Chemical Formula CH2=C(CH3)CH2C1. 

In a 1-1. round-bottomed flask equipped with a condenser are placed 78.0 g. (0.56 mole) of commercial anhydrous potassium arbonate, 45.0 g. (0.50 mole) of methallyl chloride (Note 1), 55.0 g. (0.55 mole) of 2,4-pentanedione (Note 1), and 300 ml. of anhydrous ethanol (Note 2). The mixture is refluxed on a steam bath for 16 hours. The condenser is replaced by a distilling head and condenser, and about 200 ml. of ethanol is distilled from the mixture (Note 3). Ice water (600 ml.) is added to dissolve the salts, and the mixture is extracted three times with ether. The... 

Eastman Organic Chemicals practical grade methallyl chloride was distilled (b.p. 70-71°) Union Carbide Chemicals Co. 2,4-pentanedione was distilled (b.p. 134.5-135.5°). 

Methyl-5-hexen-2-one has been prepared by alkylation of acetoacetic ester with methallyl chloride, followed by cleavage the overall yield in the two steps was 51%.2... 

Alkylation, of 2,4 pentanedione, with methallyl chloride and potassium carbonate, 47, 87... 

Malonyl dichloride, 33, 20 2-Mercaptobenzimidazole, 30, 56 2-Mercaptobenzoxazole, 30, 57 Mercuric cyanide, 32, 31 Methallyl chloride, 32, 90 MeTHANEPHOSPHORIC ACID, DnSOPRO-PYL ESTER, 31, 33 Methanesulfonic acid, 30, 58 Methaneshlfonyl chloride, 30, 58 Methanol, 30, 31 32, 79 Methone, 31, 40... 

Methallyl chloride 1-Propene, 3-chloro-2-methyl- (8,9) (563-47-3) 2-(Hydroxymethylene)cyclododecanone Cyclododecanone, 2-(hydroxymethylene)-(9) (949-07-5)... 

Methallyl chloride (obtained from Aldrich Chemical Company, Inc.) was distilled (bp 71-72°C) from phosphorus pentoxide prior to use. 

Tab. 5.8 Reaction of catechol with /J-methallyl chloride (8 mmol) in the presence of base (2 mmol) and phase-transfer catalyst (0.2 mmol) under microwave irradiation.

Rates of reaction and the course of each step depended upon the structures of the species. With a-methylstyrene and with methallyl chloride, steps (b) and (c) were not detectable perhaps (a) did not happen and the product was that of direct addition with no exchanges or isomerization. With 1-hexene, 3-methyl-1-butene-1,3-methyl-2-butene, and cyclohexene the exchanges and isomerization were much faster than step (d). By step (d) the product left the coordination sphere of the metal and no longer participated in any of the processes. 

Mercaptobutane 2-Mercaptoethanethiol 2-Methallyl Chloride 2-Methylallyl Chloride 2-Methyl-Allylchlorid 2-Methylbutanoic Acid 2-Methylbutyric Acid... 

Metanilic acid, all6 Methacholine chloride, a49 Methacrolein, m27 Methacrolein diacetate, m32 Methallyl alcohol, m400 Methallyl chloride, cl82... 

Methacrylonitrile process, 16 256—257 Methacryloyl chloride, in polyhydric alcohol formation, 2 46 Methacycline, 24 592 Methallyl chloride, production from butylenes, 4 427... 

Some cyclopropenes have been synthesized by refluxing methallyl chloride with sodium amide in the medium of THF. 

The electrosynthesis of homoallyl alcohols (193) or 8-hydroxy esters (196) has been carried out by the reaction of methallyl chloride (190) (Scheme 75) or... 

Scheme 75 Homoallyl alcohol by nickel-catalyzed addition of methallyl chloride to carbonyl...

Benzyloxy-2-methylpropane-l,2-diol, a desymmetrized form of 2-methylpropane-1,2,3-triol with its terminal hydroxy being protected as a benzyl ether, was prepared using the B. subtilis epoxide hydrolase-catalyzed enantioselective hydrolysis of the racemic benzyloxymethyl-l-methyloxirane readily available from methallyl chloride and benzyl alcohol. The preparation of the racemic epoxide, a key intermediate, was described in Procedures 1 and 2 (Sections 5.6.1 and 5.6.2), its overall yield being 78 %. The combined yield of enantiomerically pure (7 )-3-benzyloxy-2-methylpropane-l,2-diol was 74 % from ( )-benzyloxymethyl-l-methyloxirane, as described in Procedures 3-5 (Sections 5.6.3 and 5.6.5), with the overall procedures leading to the biocatalytic dihydroxylation of benzyl methallyl ether . 

Mesitylene, condensation with dichloro-methyl methyl ether, 47, 1 oxidation with peroxytrifluoroacetic acid and boron trifluoride, 48, 90 Methallyl chloride in alkylation of 2,4-pentanedione with potassium carbonate, 47, 87... 

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