5-Chloro-3-methyl-4-nitro

C3H10N2O 1,3-diamino-2-hydroxypropane 616-29-5 25.00 0,9217 2 2531 C4H4CIN302 5-chloro-3-methyl-4-nitro-1H-pyrazole 6814-58-0 25.00 1.5356 2... 

Chloro-3-methyl-4-nitro-lH-pyrazole (Release) has no auxin-, gib-berellin-, or cytokinin-like activity, yet it is an ejffective abscission agent. At the present, there is no evidence to indicate that Release retards auxin, gibberellin, or cytokinin activity. It does stimulate and enhance the tissue production of ethylene (105). Release is fairly stable, and there is no indication that it is degraded by the tissue to ethylene per se (106). 

The reaction of anilines (R = H, m- and p-CHg, m- and p-halo-geno, W-NO2, P-OCH3, P-OC2H5) with 2-chloro-3-nitro-, 2-chloro-5-nitro-, 2-chloro-3-cyano-5-nitro-, 2-chloro-3-cyano-6-methyl-5-nitro-, and 2-chloro-3-cyano-4,6-dimethyl-5-nitro-pyridines. ... 

Benzofurazan (benz-1,2,5-oxadiazole) reacted with bromine by addition to give a4,5,6,7-tetrabromo adduct. Bromine in hydrobromic acid solution 4-brominated both 5-methyl- and 5-bromo-benzofurazans (74JHC8I3). When 4,7-dinitrobenzofurazan was treated with ammonium chloride in refluxing acetic acid, nucleophilic displacement gave rise to the 4-chloro-7-nitro derivative (83URP1004375). Naphtho[l, 2-c]furazans (42) are mainly 4-halogenated, but there is minor substitution in the 8-position (73CHE1331). 

First of all, there are the two products of O-coupling addition of methoxide ion to the diazonium ion, the (Z)- and (jE)-diazo methyl ethers. As discussed in Section 6.2, they are formed in reversible reactions with half-lives of the order of a fraction of a second (Z) to a minute (E). The two diazo ethers are, however, decomposed rapidly to the final dediazoniation products. We show in Scheme 8-47 the products obtained by Broxton and McLeish (1983 b) in the dediazoniation of 4-chloro-3-nitrobenzenedi-azonium ion (8.64) with methoxide ion in CH3OH. The products are 4-chloro-3-nitro-anisole (8.65, 49 9o), 2-chloro-nitrobenzene (8.66, 449o), and 2-nitroanisole (8.67). 

Figure 12.10 Pyrogram of acrylic emulsion paints containing different organic pigments (a) PR5 (b) PR112 (c) PR4 (d) PY3 (e) PR 251 (f) PY74. Peak assignments 1, EA 2, MMA 3, nBA 4, 4 chloro 2 nitro benzenamine 5, 2 chloro benzenamine 6, 1 chloro 2 isocya nato benzene 7, 2 methoxy 4 nitro benzenamine 8, 2 methoxy benzenamine 9, 1 isocya nato 2 methoxy benzene 10, 1 chloro 4 nitro benzenamine 11,1 chloro 2 nitro benzene 12, 2 naphthalenol 13, 3 amino 4 methoxy N,N diethyl benzenesulfonamide 14, 4 meth oxy N,N diethyl benzenesulfonamide 15, 5 chloro 2,4 demethoxy benzenamine 16, 2,4,5 trichloro benzenamine 17, 1,3,4 trichloro benzene 18, 2 methyl benzenamine 19,...

Puig et al. [450] determined ng/1 levels of priority methyl-, nitro-, and chloro-phenols in river water samples by an automated on-line SPE technique, followed by liquid chromatography-mass spectrometry (LC-MS) using atmospheric pressure chemical ionization (APCI) and ion spray interfaces. 

The observed data reveals that these spiro-(3-lactams are antifungal in nature and the introduction of chloro, methyl and methoxy group further enhances the antifungal activity whereas, nitro group reduces it. The spiro-(3-lactams I were also found to exhibit strong antibacterial activity against E. coli, S. typhi, and B. aureus. 

In this section, consideration will be given to the actual processes of acetal- or ketal-formation and not to the more indirect methods by which acetals and ketals of the polyhydric alcohols may be synthesized from compounds (e.g. derivatives of the monosaccharides) containing preformed alkylidene or arylidene groupings. The condensation of a carbonyl compound with a glycol is facilitated by acidic catalysts, and, since the reaction is reversible, by dehydration. The catalysts most frequently employed are concentrated sulfuric, hydrochloric and hydro-bromic acids, gaseous hydrogen chloride, zinc chloride and cupric sulfate others are phosphorus pentoxide, sulfosalicylic acid, and anhydrous sodium sulfate. The formation of benzylidene compounds is promoted less efficiently by phosphorus pentoxide than by either concentrated sulfuric acid or concentrated hydrochloric acid 1" the reaction is assisted by chloro- and nitro-substituents on the aromatic nucleus, but hindered by methyl- and methoxy-groups.18... 

Azine approach. The parent cation and substituted derivatives are available by acid-catalyzed cyclization of 2-/3-oxoalkylthiopyridines (401) using an acid such as sulfuric, phosphoric or PPA. Chloro or nitro substituents in the pyridine ring do not seriously interfere (66JHC27). The cyclization of 3-hydroxypyridine analogues (402) is also at the nitrogen to yield the thiazole derivatives. The cyclization, however, is sensitive to the peri interaction between 3- and 5-substituents. In 3,5-dimethyl derivatives (403 R2 = R3 = Me) the steric repulsion is apparent by the unusually low field signals for the methyl protons <81H(15)1349>. 

Methyl 3-chloroformyl-2-pyrazinecarboxylate Methyl 6-chloro-5-methoxy-3-oxo-3,4-dihydro-2-pyrazinecarboxylate Methyl 6-chloro-3-methoxy-2-pyrazinecarboxylate Methyl 3-chloro-5-methyl-2-pyrazinecarboxylate Methyl 5-chloro-6-methyl-2-pyrazinecarboxylate Methyl 5-chloro-6-methyl-2-pyrazinecarboxylate 1-oxide Methyl 6-chloro-3-nitro-2-pyrazinecarboxylate Methyl 6-chloro-3-oxo-3,4-dihdyro-2-pyrazinecarboxylate... 

Table IV shows compounds which were of interest because of their anti-schistosomiasis effect. In all these compounds paramethylaniline is a common structural unit, and we believe that activity depends on transport to a site of metabolism, where hydroxylation of the methyl group occurs. An electronegative group ortho to the methyl is necessary for activity, as is an aminoalkyl side chain. In Compounds 1 and 3 this side chain is fixed in its position by ring formation alternatively, the chain may be conformationally less rigid, as in Compounds 2 and 4. Log F measurements show that additivity principles do hold for all of these compounds and also suggest that an optimum log F exists this log P0 is about 4.0, as in Compounds 1 and 2 which are the most active. Compound 3 is too lipophilic, and 4 is not lipophilic enough both are less active than 1 and 2. It would seem that either a chloro or a nitro group would activate the methyl to hydroxylation differences in activity between chloro and nitro derivatives are the result of different w effects of these groups on transport.

---