Chemical ionization reaction time-of-flight mass

Source Cordell, R.L.W., Kerry, A., Wyche, K.R, Blake, R.S., Ellis, A.M., Monks, PS. (2007) Detection of chemical weapon agents and simulants using chemical ionization reaction time-of-flight mass spectrometry. Analytical Chemistry, 79,8359 366. 

Blake RS, Wyche KP, Ellis AM, et al. Chemical ionization reaction time-of-flight mass spectrometry multi-reagent analysis for determination of trace gas composition. Int J Mass Spec-trom. 2006 254 85-93. 

Wyche, K. P., Blake, R. S., Ellis, A. M. et al. (2007) Technical Note Performance of Chemical Ionization Reaction Time-of-Flight Mass Spectrometry (CIR-TOF-MS) for the measurement of atmospherically significant oxygenated volatile organic compounds. Atmos. Chem. Phys. 7, 609. 

It is of interest to mention some detailed mass spectrometric results that were obtained by performing distinct experiments (a) ion-molecule reactions in mixtures of haloben-zenes and ammonia under chemical ionization conditions (b) ion-molecule reactions of mass-selected ionized halobenzenes toward ammonia in a quadrupole collision cell of a hybrid tandem mass spectrometer (c) ion-molecule reactions of phenyl diazonium cations with ammonia in the same quadrupole collision cell and, finally, (d) electrospray ionization of anilines in a hybrid quadrupole-time of flight mass spectrometer (QTof). Characterization of the product ions relies on collisional activation experiments in the low or high kinetic energy regime98. 

TISP, turbo ion spray MRM, multiple reaction monitoring UHPLC, ultra-high-pressure liquid chromatography TOP, time-of-flight mass analyzer ISP, ion spray SRM, selected reaction monitoring ESI, electrospray interface APCI, Atmospheric pressure chemical ionization. 

Ion attachment mass spectrometry (lAMS) has proven to be a rMque method that complements electron-impact ionization mass spectrometry for the determination of components in chemical processes and environments, such as microwave discharge plasma. The identification of intermediate free radicals and other species in chemical reactions is particularly challenging. One of the greatest advantages of lAMS is that it can be used to directly analyze gaseous compounds. The features that allow this system to detect the intermediate free radicals (refer to Sect. 5.2.4) and novel molecular species produced in various plasmas have been extensively explored (Sect. 5.2.7), and lAMS techniques can be used to identify and quantify compounds and mixtures under plasma and pyrolysis (Sect. 6.4) conditions. To extend the ion attachment technique to ion trap mass spectrometry (Sect. 6.5) or time-of-flight mass spectrometry (Sect. 6.6) has been realized. 

See also Atmospheric Pressure Ionization in Mass Spectrometry Biochemical Applications of Mass Spectrometry Chemical Ionization in Mass Spectrometry Chemical Structure Information from Mass Spectrometry Fast Atom Bombardment Ionization in Mass Spectrometry Forensic Science, Applications of Mass Spectrometry Hyphenated Techniques, Applications of in Mass Spectrometry Ion Molecule Reactions in Mass Spectrometry Ion Trap Mass Spectrometers Isotopic Labelling in Mass Spectrometry Medical Applications of Mass Spectrometry MS-MS and MS" Peptides and Proteins Studied Using Mass Spectrometry Quadrupoles, Use of in Mass Spectrometry Sector Mass Spectrometers Thermospray Ionization in Mass Spectrometry Time of Flight Mass Spectrometers. 

GC-FID, gas chromatography flame ionization detection GCMS, gas chromatography mass spectrometry APcI-TOFMS, atmospheric pressure chemical ionization-time of flight mass spectrometry PTRMS, proton-transfer-reaction mass spectrometry. 

Abend, Block, Cocke, Time-of-Right] Abend, Gunter/Jochen H. Block/David L Cocke The Field Ionization Time-of-Flight Mass Spectrometer. A Tool for Chemical Kinetic Investigations as Shown by Elemental Sulphur Reactions, Advances in Mass Spectrometry 7 (1979), p. 703-705. 

Various analyzers have been used to analyze phenolic compounds. The choice of the MS analyzer is influenced by the main objective of the study. The triple quadrupole (QqQ) has been used to quantify, applying multiple reaction monitoring experiments, whereas the ion trap has been used for both identification and structure elucidation of phenolic compounds. Moreover, time-of-flight (TOF) and Fourier-transform ion cyclotron resonance (FT-ICR) are mainly recommended for studies focused on obtaining accurate mass measurements with errors below 5 ppm and sub-ppm errors, respectively (Werner and others 2008). Nowadays, hybrid equipment also exists, including different ionization sources with different analyzers, for instance electrospray or atmospheric pressure chemical ionization with triple quadrupole and time-of-flight (Waridel and others 2001). 

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