Medical applications mass spectrometry

Lindinger, W., Fall, R., Karl, T.G. (2001) Environmental, food and medical applications of proton-transfer-reaction mass spectrometry (PTR-MS). Adv. Gas Phase Ion Chem. 4 1-48. 

Biological and medical imaging from single proteins to the whole human brain to provide graphic displays of anatomic detail and physiological function. Several applications in imaging mass spectrometry in human brain research are summarized in Section 9.5.7 ... 

The goal of Chapter 6 is to familiarize investigators in biological and medical research with mass spectrometry and its potential applications in these fields, with the anticipation that it will encourage and enable them to utilize MS in their research. An attempt has been made to provide a clear basic description of the modern mass spectrometers and of the most relevant types of experiments that they can perform. Discussed also are the advantages and drawbacks of the different methods in the context of biological research with examples of the ability of mass spectrometry to solve problems in this field of research. 

The application of speciated isotope dilution mass spectrometry (SIDMS) in speciation analysis was described and discussed by Huo et al. [236]. According to Encinar [237], isotopic analysis of a solution can be used to evaluate the application of various speciation forms of elements in food and in medications. 

Zhan, X., Duan, J., Duan, Y. Recent developments of proton-transfer reaction mass spectrometry (PTR-MS) and its applications in medical research. Mass Spectrom. Rev. 32, 143-165 (2013)... 

JA Loo, DE De-John, RRO Loo, PC Andrews. Application of mass spectrometry for characterizing and identifying ligands from combinatorial libraries. Ann Rep Medic Chem 31 319-325, 1996. 

ENVIRONMENTAL, EOOD AND MEDICAL APPLICATIONS OF PROTON-TRANSFER-REACTION MASS SPECTROMETRY (PTR-MS)... 

The development of proton-transfer-reaction mass spectrometry (PTR-MS) as a tool for the analysis of volatile organic compounds (VOCs) is described. PTR-MS is based on the rapid, non-dissociative transfer of protons from H30 to most common VOCs, but not to the principal gases in the air sample. Recent developments in the design of PTR-MS instruments allow detection of some VOCs in the parts per trillion by volume range. This sensitivity and the capability of PTR-MS instruments to be operated for extended periods in both laboratory and field settings has allowed exploration of many aspects of VOC analysis in environmental, food and medical applications. 

We have briefly mentioned the use of data on IMR in plasma modeling and for the understanding of interstellar molecular synthesis as well as of ionospheric chemistry, and we also want to point out the applications of IMR in various methods of chemical ionization. The most recent one, developed in our laboratory, namely proton-transfer reaction mass spectrometry (PTR-MS), allows for on-line monitoring of volatile organic compounds at levels as low as a few parts per trillion and is therefore applicable for environmental, food, and medical research involving investigations of fast metabolic and enzymatic processes. 

FDMSi " is a soft ionization technique which expands the applicability of mass spectrometry to highly polar and/or thermally labile compounds and therefore has found numerous analytical applications in biochemical, medical and environmental research Although originally designed and developed for ionization of organic compounds of low volatility the technique has unexpectedly proved to be a powerful tool in the analysis of a large number of metals. 

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