Ion-attachment mass spectrometry

M. Nakamura et al.. In situ analysis of perfluoro compounds in semiconductor process exhaust Use of Li+ ion-attachment mass spectrometry, J. Vac. Sci. TechnoL, A, 19, 1105, 2001. 

This feature has recently permitted the development of ion attachment mass spectrometry in the ion trap with sodium ion as a reagent ion (Section 16.4.3.2). 

Those are, for instance, known as active chemical ionization mass spectrometry (ACIMS) for atmospheric trace-gas measurements in the chemosphere, proton transfer reaction mass spectrometry (PRT-MS), selected ion flow tube mass spectrometry (SIFT-MS), ion-molectrle reaction mass spectrometry (IMR-MS), ion attachment mass spectrometry (lAMS), and ion mobility spectroscopy (IMS). Those have now become part of the exterrsive resources of experimental techniques dedicated to all the scientific fields, especially such as fundamentals of gas-phase ion kinetics and thermochentistry, physical organic chemistry, atmospheric chemistry, interstellar chemistry, plasma, and combustion chemistry, radiation chemistry, analytical chemistry, and irltimately even medicine and biology. 

Sablier M, Fujii T. Mass spectrometry office radicals. Chem. Rev. 2002 102 2855-924. Fujii T. Ion attachment mass spectrometry. In Gross LM, Caprioli, RM. Editors. Encyclopaedia of mass spectrometry. American Society for Mass Spectroscopy. Vol. 6. New York Elsevier, 2007. pp. 327-34. 

Selvin PC, Fujii T. Fithium ion attachment mass spectrometry instrumentation and features. Rev Sei Instrum. 2001 72 2248-52. 

Alkali metal ion/molecule association reactions have been exploited in various mass spectrometric methods since the early 1970s. Initial studies were to determine metal ion affinities of simple compounds, with use of Fourier transform ion cyclotron resonance (FTICR) mass spectrometers. Alkali ions offer unique and interesting potential in analytical chemistry and studies of chemical dynamics. Consequently, the use of metal ions as reagents for Cl mass spectrometry has been developed. The major advances in the apphcation of MS as a routine analytical instmment using the complex ion/molecule chemistry came arotmd in the past decades. They include atmospheric pressure chemical ionization (APCI), proton transfer reaction mass spectrometry (PTR-MS), selected ion flow tube mass spectrometry (SIFT-MS), ion attachment mass spectrometry (lAMS) and ion molecrtle reaction mass spectrometry (IMM-MS). 

Fig. 5.8 Simulation system for the diagnosis of diamond deposition CVD with Li ion attachment mass spectrometry. (Reprinted with permission from [93]. 2001, American Institute of Physics)...

Fujii T. Ion attachment mass spectrometry, Vol 6 ionization methods. In Gross M, editors. Encyclopedia of mass spectrometry. America society for mass spectrometry. New York Elsevier 2007. pp 327-34. 

Fujii T. A new method for thermal analysis ion-attachment mass spectrometry (lAMS). J Therm Anal Calorim. 2012 110 17-25. 

Kitahara Y, Takahashi S, Tsukagosi M, Juhasz M, Fujii T. Ion attachment mass spectrometry for environmental analysis. In Gauglitz G, Moore DS, editors. Handbook of spectroscopy, 2nd edn vol 3. London Wiley-VCH 2014. pp. 1287-312. 

Fujii T, Selvin PC, Sablier M, Iwase K. Lithium ion attachment mass spectrometry for on-line analysis of trace components in air direct introduction. Int J Mass Spectrom. 2001 209 39-45. 

Fuji T, Arulmozhiraja S, Nakamura N, Shiokawa Y. Detection of Cu(hfacXtmvs) by ion attachment mass spectrometry. Chem Phys Lett. 2006 425 134-7. 

Fujii T, Arulmozhirqa S, Nakamura M, Shiokawa Y. Chemistry of Cu deposition by Cu(hfacXtmvs) monitored by Li+ ion attachment mass Spectrometry. J Appl Phys. 2006 100 084912. 

Sato Y, Oki M, Kondo A, Takenaka M, Satake H. Rapid analysis of polybrominated diphenyl ethers by ion attachment mass spectrometry. Anal Methods. 2010, 2 701-6. 

Maruyama H, Homma K, Wada A, Shiokawa Y. The rapid analysis of PBDEs (poly brominated diphenyl ethers) utilizing the ion attachment mass spectrometry. Organohalogen Compd. 2007 69 2767-68. 

Vitamin C and Ion attachment mass spectrometry with a temperature-pro-grarmned direct probe allows the detection of irrtact pyrolysis products. It, therefore, offers the opportunity to monitor directly thermal byproducts on a real-time basis and potentially to detect thermally imstable products. EGA-IAMS is used to study the real-time, non-isothermal decomposition of vitamin C [30]. The results were compared with those obtained in a similar study on thermal decomposition of vitamin C using pyrolysis GC/MS. Significant differences were found between the two techniques, in terms of the nature and relative amoimts of products formed. A major difference between the two techniques was in the transportation time of the pyrolysis products out of the pyrolysis chamber (or hot zone). The time was significantly shorter in EGA-IAMS than in pyrolysis GC/MS, which reduces the occmrcnce of secondary reactions of the primary pyrolysis products. Some decomposition products formed in the EGA-IAMS system were not detected in the previous pyrolysis GC/MS study [38] and thus were detected for the first time. For instance, dehydro-L-ascorbic acid was observed as a decomposition product. This compoimd was the main degradation product detected by means of EGA-IAMS. While it is an important compoimd because it possesses some biological activity, dehydro-L-ascotbic acid is difficult to measure due to its chemical instabihty. 

Ion attachment mass spectrometry (lAMS) has proven to be a rMque method that complements electron-impact ionization mass spectrometry for the determination of components in chemical processes and environments, such as microwave discharge plasma. The identification of intermediate free radicals and other species in chemical reactions is particularly challenging. One of the greatest advantages of lAMS is that it can be used to directly analyze gaseous compounds. The features that allow this system to detect the intermediate free radicals (refer to Sect. 5.2.4) and novel molecular species produced in various plasmas have been extensively explored (Sect. 5.2.7), and lAMS techniques can be used to identify and quantify compounds and mixtures under plasma and pyrolysis (Sect. 6.4) conditions. To extend the ion attachment technique to ion trap mass spectrometry (Sect. 6.5) or time-of-flight mass spectrometry (Sect. 6.6) has been realized. 

Tsugoshi T, Nagaoka T, Nakamura M, Shiokawa Y, Watari K. Application of ion attachment mass spectrometry to evolved gas analysis for in situ monitoring of porous ceramic processing. Anal Chem. 2006 78 2366-9... 

Juhasz M, Kitahara Y Fujii T. Thermal decomposition of vitamin C an evolved gas analysis-ion attachment mass spectrometry study. Food Chem. 2011 129 546-50. 

Tutas M, Saglam M, Yuksel M, Guler C. Investigation of the thermal decomposition kinetics of polyacrylamide using adynamic TG technique. Thermochim Acta. 1987 111 121-6. Kitahara Y, Okuyama K, Ozawa K, Suga T, Takahashi S, Fujii T. Thermal decomposition of acrylamide from polyacrylamide time-resolved pyrolysis with ion-attachment mass spectrometry. J Therm Anal Calorim. 2012 110 423-9. 

Takahashi S, Suga T, Kitahara Y, Eujii T. Evolved gas analysis of Ti(C5H5)2Cl2 by means of Li Ion attachment mass spectrometry. J PhysChem A 2012 116 865-9. 

Takahashi S, Kitahara Y, Nakamura M, Shiokawa Y, Fujii T. Temperature-resolved thermal analysis of cisplatin by means of Li ion attachment mass spectrometry. Phys Chem Chem Phys. 2010 12 3910-3. 

Kitahara Y Takahashi S, Fujii T. Thermal analysis of polyethylene glycol evolved gas analysis with ion attachment mass spectrometry. Chemosphere. 2012 88 663-9. 

Takahashi S, Nakamura M, Fujii T. Design and performance of a compact Li ion attachment mass spectrometry system with an atmospheric sampling device. J Am Soc Mass Spectrom. 

The characterization of reactive intermediate, flee radical has been one of the most important challenges for the scientist in the history of chemistry. In early times, MS has appeared as a direct method to study radical intermediates due to its irmnediate response in the analysis. Among the variorrs original methods developed in the prrrpose of detecting and characterizing free radicals in dynamic chemical systems such as plasmas and combustion, the ion attachment mass spectrometry... 

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