Cervical carcinoma cell

Hietanen, S., et al., Activation of p53 in cervical carcinoma cells by small molecules. Proc Natl Acad Sci USA, 2000, 97(15), 8501-6. 

M. W. R. Robertson, M. Wang, G. P. Siegal, M. Rosenfeld, R. S. N. Ashford, R. D. Alvarez, R. I. Garver, and D. T. Curiel, Use of a tissue-specific promoter for targeted expression of the herpes simplex virus thymidine kinase gene in cervical carcinoma cells, Cancer Gene Ther. 5 331 (1998). 

Goodwin, E. C., and DiMaio, D. (2001). Induced senescence in HeLa cervical carcinoma cells containing elevated telomerase activity and extended telomeres. Cell Growth Differ. 12 525-534. 

KB (human epidermoid carcinoma) and HeLa (human cervical carcinoma) cell lines are purchased from DSMZ, Germany. 

Another group of closely related compounds is the phenstatins. Phenstatin (6a) and hydroxyphenstatin (6b) resulted from a SAR-study on combretastatin A-4 and exhibited potent inhibition of cancer cell growth [29]. Further modifications have been performed, resulting in highly potent agents, namely 243869 (6c) with in vitro toxicity of IC5o = 0.58 nM towards HeLa cervical carcinoma cells [40,41]. 

Schneider Berlin KR, Ammini CV, Rowe TC (1998) Dequalininm induces a selective depletion of mitochondrial DNA frinn HeLa human cervical carcinoma cells. Exp Cell Res 245 137-145 Schneider E, Hsiang YH, liu LF (1990) DNA topoisomerases as anticancer drag targets. Adv Pharmacol 21 149—183... 

Zacharewski et al. (1998) found that di- -butyl phthalate induced reporter gene (luciferase) activity in MCF-7 human breast cancer cells, but not HeLa human cervical carcinoma cells, transfected with human estrogen receptor, although approximately 3,000-fold less potent than 17p-estradiol. Additionally, Zacharewski et al. (1998) found that di- -butyl phthalate was capable of supporting a very modest amount... 

In a screening on the effects of poria on chemotherapy drug uptake in human cervical carcinoma cells, an aqueous extract of poria enhanced the target cell sensitivity to the p-glycoprotein (P-gp) substrate paclitaxel, with no changes in sensitivity to 5-fluorouracil, which is not a substrate for P-gp. Poria increased cellular uptake of rhodamine 123 (Takara et al. 2005). 

Conflicting data have been published as to the protection from TNF-mediated cytolysis by the E1B/19K protein. In several human cell lines (HEL-299 fibroblasts and cervical carcinoma cells ME-180 and HeLa), sensitized to TNF cytolysis by... 

HeLa human cervical carcinoma cell line... 

Many researchers have conducted in vitro studies on the potential anticancer activity of flavones and flavonols in diverse cell systems. An array of 55 flavones having a variety of substituents was evaluated by Cushman and Nagarathnam for cytotoxicity in five cancer cell cultures, A-549 lung carcinoma, MCF-7 breast carcinoma, HT-29 colon adenocarcinoma, SKMEL-5 melanoma, and MLM melanoma [151]. Other reports also revealed that flavones and flavonols exhibited cytotoxicity in vitro to many human cell lines, including esophageal cancer cells [152, 153], colon cancer cells [154, 155], hepatoma cells [156, 157], prostate carcinoma cells [158, 159], and cervical carcinoma cells [160, 161],... 

King TJ, Fukushima LH, Hieber AD, Shimabukuro KA, Sakr WA, Bertram JS (2000) Reduced levels of connexin 43 in cervical dysplasia inducible expression in a cervical carcinoma cell line decreases neoplastic potential with implications for tumor progression. Carcinogenesis 21 1097-1109... 

The most common application of BLI in cancer research is the use of stably transfected, luciferase expressing mmor cell lines where the luciferase signal is used as a measure of tumor burden and metastasis (55). The first example of this approach used the human cervical carcinoma cell line, HeLa (56,57). HeLa cells labeled with luciferase were injected into severe combined immunodeficient mice via the tail vein, and cells were immediately apparent in the lung. This model has since been used to examine lung colonization by several tumor cell lines. These, and now many other studies, have demonstrated that luciferase expression correlates with tumor burden through the use of many ex vivo assays and through the use of other imaging modalities (25,56,57). 

Figure 10.21 Infrared absorbance spectrum of single A431 cervical carcinoma cell.

Oridate N, Suzuki S, Higuchi M, Mitchell MF, Hong WK, Lotan R (1997) Involvement of reactive oxygen species in V-(4-hydroxyphenyl)retinamide-induced apoptosis in cervical carcinoma cells. J Nat Cancer Inst 89 1191-1198... 

Ryu S, Kim OB, Kim SH, He SQ, Kim JH (1998) In vitro radiosensitization of human cervical carcinoma cells by combined use of 13-d5-retinoic acid and interferon-a2a. Int J Radiat Oncol Biol Phys 41 869-873... 

Lancillotti F, Giandomenico V, Affabris E, Fiorucci G, Romeo G, Rossi G (1995) Interferon a-2b and retinoic acid combined treatment effects proliferation and gene expression of human cervical carcinoma cells. Cancer Res 55 3158-3164... 

---