Cancer cell growth

It is important to note that diet is a complex mixture that contain compounds with varying activity. Chemical stimulators of colon cancer growth include bile acids, 1,2-diglycerides and prostaglandins which stem from consumption of fat. In contrast, fruits and vegetables contain substances such as carotenoids, flavonoids and fibre, which may inhibit cancer cell growth, and the risk of colon cancer appears to be mirrored by the ratio of plant sterols to cholesterol in the... 

Cha, T.L. et al., Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth, Cancer Res., 65, 2287, 2005. 

Lian, F., D. E. Smith, H. Ernst, R. M. Russell, and X. D. Wang. 2007. Apo-lO -lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis 28(7) 1567-1574. 

Nahum, A., L. Zeller, M. Danilenko et al. 2006. Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin Dl. Eur JNutr 45(5) 275—282. 

Williams, A.W., Boileau, T.W., Zhou, J.R., Clinton, S.K., and Erdman, J.W. Jr. 2000 Beta-carotene modulates human prostate cancer cell growth and may undergo intracellular metabolism to retinol. J Nutr 130 728-732. 

G9a, also known as EHMT2, is overexpressed in human cancers and knockdown of G9a inhibits cancer cell growth [35]. In addition, G9a inactivates the tumor suppressor p53 via dimethylation of lysine 373 [22]. 

Jing P, Bomser JA, Schwartz SJ, He J, Magnuson BA and Giusti MM. 2008. Structure-function relationships of anthocyanins from various anthocyanin-rich extracts on the inhibition of colon cancer cell growth. 

Kleinman D, Karas M, Danilenko M (1996) Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction of IGF binding proteins. Endocrinology 137 1089-1095... 

Choi YH, Kang HS, Yoo MA. (2003) Suppression of human prostate cancer cell growth by betalapachone via down-regulation of pRB phosphorylation and induction of Cdk inhibitor p21(WAFl/CIPl). J Biochem Mol Biol 36 223-229. 

Presently it is under Phase 1 clinical trials for breast and prostate cancer. It has shown inhibitory activity for cancer cell growth and proliferation. The mechanism of anticancer activity is believed to be the... 

Wu JT, Archer SY, Hinnebnsch B, Meng S, Hodin RA. (2001) Transient vs. prolonged histone hyperacetylation Effects on colon cancer cell growth, differentiation, and apoptosis. Am J Physiol Gastrointest Liver Physiol 280 G482-G490. 

Chemistry, biology, and QSAR studies of substituted hiaryl hydroxamates and mercaptoacetamides as HDAC inhibitors-nanomolar-potency inhibitors of pancreatic cancer cell growth. ChemMedChem, 3, 487-501. 

Several studies have shown the ability of DNMT inhibitors to prevent cancer using different pathways [101-104]. Genistein demonstrated cancer chemopreventive activities in animal models [105]. It has been studied in different cancer cell lines and inhibition of cancer cell growth has been shown [106]. But several mechanisms, such as antihormonal effects, are discussed to explain this activity and the exact contribution of DNMT inhibition to in-vivo activity in cancer chemoprevention remains to be determined. 

Suzuki, T., Nagano, Y, Kouketsu, A., Matsuura, A., Maruyama, S., Kurotaki, M. et al. (2005) Novel Inhibitors of human histone deacetylases design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. Journal of Medicinal Chemistry, 48, 1019—1032. 

SMYD2 (KMT3C) SMYD3 Suppressor of p53 transcriptional activity [34] Overexpression and enhanced breast cancer cell growth [93] Overexpression also in colorectal and hepatocellular carcinoma [94] H3K56, p53K370... 

Fig.1 Some Src-dependent signal transduction pathways related to cancer cell growth, survival and migrations (adapted from Sawyer et al. [32])...

Tuckmantel, W., Kozikowski, A.P., and Romanczyk, L.J. Jr., Studies in polyphenol chemistry and bioactivity. 1. Preparation of building blocks from (+)-catechin. Procyanidin formation. Synthesis of the cancer cell growth inhibitor, 3-0-galloyl-(2R,3R)-epicatechin-4(3,8-[3,0-galloyl-(2R,3R)-epicatechin], J. Am. Chem. Soc., 121, 12073, 1999. 

The most reasonable approach for addressing this dilemma is to exploit differences in cell growth kinetics between cancer cells and host cells. A hallmark of cancerous cell growth is the rapidity of its cellular proliferation. At any given time, a malignant tumor should have more cells undergoing mitosis and replication than other tissues in the host. 

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