Human estrogen receptor

Metzger, D., Ah, S., Bomert, J.M., and Chambon, P. (1995). Characterization of the amino-terminal transcriptional activation function of the human estrogen-receptor in animal and yeast-ceUs. Journal of Biological Chemistry 270, 9535-9542. [Pg.360]

Tran, D.Q., Ide, C.R, and McLachlan, J.A. et al. (1996). The anti-estrogenic activity of selected polynuclear aromatic hydrocarbons in yeast expressing human estrogen receptor. Biochemical and Biophysical Research Communications 229, 102-108. [Pg.371]

OGAWA S, INOUE S, WATANABE T, HIROI H, ORIMO A, HOSOI T, OUCHI Y, MURAMATSU M (1998) The complete primary structure of human estrogen receptor beta (hER beta) and its heterodimerization with ER alpha in vivo and in vitro. Biochem Biophys Res Commun. 234 122-6. [Pg.84]

Hall JM, McDonnell DP (1999) The estrogen receptor beta-isoform of the human estrogen receptor modulates ER-alpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140 5566... [Pg.58]

Kumar V, Green S, Stack G, Berry M, Jin JR, Chambon P (1987) Functional domains of the human estrogen receptor. Cell 51 941... [Pg.58]

McDonnell DP, Norris JD (2002) Connections and regulation of the human estrogen receptor. Science 296 1642... [Pg.59]

Tora L, White J, Brou C, Tasset D, Webster N, Scheer E, Chambon P (1989) The human estrogen receptor has two independent nonacidis transcriptional activation functions. Cell 59 477... [Pg.61]

Tzukerman MT, Esty A, Santiso-Mere D, Danielian P, Parker MG, Stein RB, Pike JW, McDonnell DP (1994) Human estrogen receptor transactivational capacity is deter-minedbyboth cellular and promoter context and mediated by two functionally distinct intramolecular regions. Mol Endocrinol 8 21... [Pg.61]

Mclnerney EM, Weis KE, Sun J, Mosselman S, Katzenellenbogen BS (1998) Transcription activation by the human estrogen receptor subtype beta (ERb) studied with ERa and ERb receptor chimeras. Endocrinology 139 4513... [Pg.62]

Schafer JI, Liu H, Tonetti DA, Jordan VC (1999) The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor. Cancer Res 59 4308-4313... [Pg.168]

Wijayaratne AL, McDonnell DP (2001) The human estrogen receptor-alpha is a ubiq-uitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J Biol Chem 276 35684-35692... [Pg.168]

This is a third-generation SERM. It binds with high affinity to human estrogen receptors and acts as a tissue-selective estrogen antagonist or agonist. [Pg.293]

Phytoestrogens are a diverse group of polyphenolic non-steroidal plant compounds that bind to human estrogen receptors (Cos et al., 2003). The best studied of these compounds are the isoflavones, the phytoestrogens present in soy and red clover. [Pg.92]

A. J. Oosterkamp, M. T. Villaverde Herraiz, H. Irth, U. R. Tjaden, J. van der Greef Reversed-phase liquid chromatography coupled on-line to receptor afSnity detection based on the human estrogen receptor. Anal Chem 1996, 68, 1201-1206. [Pg.214]

R. B. Ultrafiltration tandem mass spectrometry of estrogens for characterization of structure and affinity for human estrogen receptors. J. Am. Soc. Mass Spectrom. 2005, 16, 271-279. [Pg.281]

OECD. 2006e. Stably transfected transcriptional activation TA) assay for detecting estrogenic activity of chemicals - The human estrogen receptor alpha mediated reporter gene assay using HeLa-hER-9903 cell line. Version October 2006. Paris OECD, http //www.oecd.org/dataoecd/49/55/37531918.pdf... [Pg.207]

For the sake of comparison, the 3-character code for the human estrogen receptor subtype a is 3.A.1, whereas the NC-IUPHAR RC would be 4.1.3 EST 1 ERA HUMAN 00. [Pg.45]

Lewis, D.F.V. et al. (2002) Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor a (hERa) LBD quantitative structure-activity... [Pg.75]

Arnold, S. F., Melamed, M., Yorojelkina, D. P., Notides, A. C., and Sasson. S. 1997. Estradiolbinding capacity of the human estrogen receptor is regulated by tyrosine phosphorylation. Mol. Endocrinol. 77 48-53. [Pg.306]

Kenealy, M.-R., Flouriot, G., Sonntag-Buck, V., Dandekar, T., Brand, H., and Gannon, F. 2000. The 3-untranslated region of the human estrogen receptor a gene mediates rapid messenger ribonucleic acid turnover. Endocrinology 747 2805-2813. [Pg.325]

Montano, M. M., Muller, V., Trobaugh, A., and Katzenellenboger, B. S. 1995. The carboxy-terminal F domain of the human estrogen receptor Role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antigonists. Mol. Endocrinol. 9 814—825. [Pg.332]

Mosselman, S., Polman, J., and Dijkema, R. 1996. ER beta Identification and characterization of a novel human estrogen receptor. FEBS Lett. 392 49-53. [Pg.332]

Traish, A. M., and Pavao, M. 1996. Binding of site-directed monoclonal antibodies to an epitope located in the A/B region (amino acids 140-154) of human estrogen receptor-induced conformational changes in an epitope in the DNA-binding domain. Steroids 61 549-556. [Pg.345]

PHAM T A, HWUNG Y P, SANTISO M D, MCDONNELL D P and O MALLEY B W, Ligand-dependant and independent function of the transactivation regions of the human estrogen receptor in yeast , Mol Endocr 1992 6 1043-50. [Pg.104]

Pink JJ, Wu SQ, Wolf DM, Bilimoria MM, Jordan YC. A novel 80kDa human estrogen receptor containing a duplication of exons 6 and 7. Nucleic Acids Res 1996 24(5) 962-969. [Pg.101]

E7. Enmark, E., Pelto-Huikko, M., Grandien, K., Lagercrantz, S., Lagercrantz, J., et al., Human estrogen receptor (3-gene structure, chromosomal localisation, and expression pattern. J. Clin. Endocrinol. Metab. 82, 4258 1265 (1997). [Pg.145]

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