Broad safety

The Commission and the CSM also made recommendations on the introduction of many other broad safety measures. These included the Phen-acetin Prohibition Order (SI 1974/1082), presentation of medicines in relation to child safety (SI 1975/2000), and declaration of alcohol in medicinal products on their package as active ingredient where this is likely to be pharmacologically active. Other labelling issues culminated in an Order (SI 1976/1726) that set out the standard particulars that must be shown on the containers and packaging of medicinal products. Consultations on other generally applicable warnings on the labels of certain medicines to protect children and to ensure that... 

The broad safety and focused safety panels of functional GPCR assays offered by Millipore. 

The naturally occurring nucleoside antibiotic pyrazofurine, CsiHnNsOs (38), shows broad-spectrum antiviral activity and a broad safety margin against boili RNA and DNA viruses in vitro. 

The initial emphasis in analytical biotechnology was on broad safety concerns that translated into detection of host-cell components such as DNA, endotoxins, Escherichia colt proteins, and retroviral contamination.2 The detection of these impurities requires development of high-sensitivity assays that are based primarily on antibodies [e.g., enzyme-linked immunosorbent assay (ELISA) for E. coli proteins) or radioactivity (e.g., dot-blot assays for DNA detection). New developments are focused on low-sensitivity detection, characterization, and removal of undesirable target sequence variants. Bioseparations play an important role even after a product has been isolated and shown to contain a low level of contaminants for initiation of clinical studies. The focus shifts to achievement of a reproducible, large-scale manufacturing process. At this stage, analytical methods provide essential informa-... 

This paper first provides a brief description of the U.S. plutonium immobilization using ceramic processing. A systematic approach for identifying and solving possible technical safety issues is introduced in Section 3. Technical and other broad safety issues specifically associated with the ceramic processing for excess plutonium immobilization are summarized in Section 4. A brief conclusion is given in Section 5. It should be emphasized that the results are preliminary, since at this moment the details of the facility and equipment designs are not yet available. 

A safety case regime is an objective-based regime whereby legislation sets broad safety objectives and the operator, who accepts direct responsibility for the ongoing management of safety, develops the most appropriate methods to... 

There is a broad safety concern that tihese events may be precursors of more significant control rod problems affecting the required shutdown margins and rod droptimes necessary to terminate certain DBAs properly. The CRDM failures of sticking control rods in the upper position have been considered even more safety significant. 

The group first discussed what safer means. Does it mean safety from terrorism, natural disasters, disease, hunger, etc. We can define safety specifically or broadly. Defined broadly, safety concerns are related to inequahties in the way basic human needs across the world are met. These inequalities make the world an unsafe place. Engineers need to be aware of political and ethical issues of inequality in the United States and abroad and become more involved in policy making to address these issues at the local and national levels. 

Variation is the fluctuations that can occur based on inconsistent environmental, human actions, equipment, tools, etc. Fluctuations of injuries and behaviors occur due to these variations in actions and conditions in the workplace. The statistical process control (SPC) (used in quality management) can aid in the review of injuries and observations, the organization can show the variations in its system. The SPC show whether the system is out of control and needs specific issues addressed or if it is in control but requires major across the broad safety program improvements (Daniels and Daniels, 2004 Deming, 1986). 

With reduced sensor cost the range of appHcations now includes thermal vision (2,3) industrial processing, industrial security, poHce work (3), maritime safety, airline safety and vision enhancement for night driving and flying and weather sateUites. For these appHcations, the thermal sensor typically uses a broad spectral band to achieve highest sensitivity. 

Because of the wide variation in the composition of natural gas as it is recovered at the wellhead and because natural gas can be used over a wide range of hydrocarbon contents, any specification for natural gas is usually broadly defined. However, the natural gas obtained at the wellhead usually undergoes some type of treatment or processing prior to its use for safety, economic, or system and material compatibiUty reasons. 

The four process control parameters are temperature, pressure, flow, and level. Modem process level detection systems are varied and ubiquitous in modem chemical plants there are thousands of processes requiring Hquid level indication and Hquid level control. From accumulators to wet wells, the need for level devices is based on the need for plant efficiency, safety, quaUty control, and data logging. Unfortunately, no single level measurement technology works rehably on all chemical plant appHcations. This fact has spawned a broad selection of level indication and control device technologies, each of which operates successfully on specific appHcations. 

Underwriters Laboratories 333 Pfingsten Road Northbrook, Id. 60062 Standards for Safety is ahst of more than 200 standards that provide specifications and requirements for constmetion and performance under test and in actual use of a broad range of electrical apparatus and equipment, including household appHances, fire-extinguishing and fire protection devices and equipment, and many other nongenerady classifiable items, eg, ladders, sweeping compounds, waste cans, and roof jacks for trader coaches. 

The Occupational Safety and Health Act (OSHA) covers a broad range of issues relating to worker health and safety, many of which impact the power generation industry (16,17). The Act sets standards designed to protect worker health and safety, particularly in industrial settings. The Occupational Health and Safety Administration, organized under the U.S. Department of Labor, implements and enforces OSHA standards and periodically updates poHcies governing worker health and safety. 

Sensors form a very broad-based, multihilHon doUar business. Detailed information and predictions of the growth in the many sensor subftelds can be found in the Hterature (39). Eor example, the relatively narrow area of acceleration and vibrations sensors was a 600 million business in 1995 and projected to become a 1 biUion business by the end of the twentieth century. New appHcations, often driven by regulatory and safety concerns, mean projected growth of just about every sensor type. 

Industrial solvent appHcations are broad, varied, and complex and each has its own set of characteristics and requirements. Proper solvent selection and blend development have a large impact on the success of the operation in which the solvent is used, from the perspectives of economic effects, technical adequacy, safety issues, and environmental impacts. 

The final choice of a suitable antimycotic and the route of adniinistration are deterrnined by many factors safety of the antimycotic, easy adniinistration, broad-spectmm activity, and rapid clinical improvement associated with mycological cure. 

Ketoconazole. For treatment of systemic mycoses with amphotericin B or miconazole, the patient must be admitted to a hospital. This is not always possible, particularly in areas where systemic mycoses occur frequently, nor is it always desirable, because of the expense. For these reasons, it was desirable to find an antimycotic that combined safety and broad-spectmm activity with oral adraiinistration. Ketoconazole (10), which is orally active, met most of these requirements. This inhibitor of the ergosterol biosynthesis is an A/-substituted imidazole, that differs from its precursors by the presence of a dioxolane ring (6,7). Ketoconazole is rapidly absorbed in the digestive system after oral adrninistration. Sufficient gastric acid is required to dissolve the compound and for absorption. Therefore, medication that affects gastric acidity (for example, cimetidine and antacids) should not be combined with ketoconazole. 

The fact that batch processes are not carried out at steady state conditions imposes broad demands on the control system. The instrumentation and control system have to be selected to provide adequate control for a wide variety of operating conditions and a wide variety of processes. In addition, basic process control and shutdown systems have to deal with sequencing issues. This chapter presents issues and concerns related to safety of instrumentation and control in batch reaction systems, and provides potential solutions. 

Hazardous Material In a broad sense, any substanee or mixture of substanees having properties eapable of produeing adverse effeets on health, safety or the environment. These dangers may arise from but are not limited to tox-ieity, reaetivity, instability, or eorrosivity. 

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