B lymphoma

Sapra P, Moase EH, Ma J, et al. Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab fragments. Clin Cancer Res 2004 10 1100. 

Cai et al. [37] SW CNT-1-plasmid DNA, with nickel under the influence of a magnetic field High efficiency of transduction of SW CNT-DNA conjugates in lymphoma cells (Ball 7 B-lymphoma)... 

Golay J, Zaffaroni L, Vaccari T et al. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro CD55 and CD59 regulate complement-mediated cell lysis. Blood 2000 95 3900-3908. 

Beckwith, M. Fenton, R.G. Katona, I.M. Longo, D.L. Phosphatidylinosi-tol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human b-lymphoma cell line. Blood, 87, 202-210 (1996)... 

Berinstein, N Levy, S., Levy, R. (1989). Activation of an excluded immunoglobulin allele in a human B lymphoma cell line. Science 244, 337-339. 

It was shown that oral administration of curcumin (50 200 mg/kg) inhibits the development of lymphoma (SGC7901) cell-induced xenografts in nude mice [Goel et al., 2007]. Curcumin inhibited the growth of both murine and human B lymphoma cells in vitro and murine B lymphoma cells in vivo by the down-regulation of spleen tyrosine kinase (Syk) activity accompanied by the down-regulation of Akt activation [Gururajan et al., 2007]. 

Gururajan M, Dasu T, Shahidain S, Jennings CD, Robertson DA, Rangnekar VM, Bondada S. 2007. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol 178 111-121. 

Biosynthesis of Blood-Group Related Glycosphingolipids in T- and B-Lymphomas and Neuroblastoma Cells... 

Yi, A.K., Hombeck, P., Lafrenz, D.E. and Krieg, A.M. (1996b) CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL. J. Immunol., 157, 4918 1925. 

Monocyte-macrophages are the only principal cells of the immune system that can synthesize all the eicosanoids. T and B lymphocytes are interesting exceptions to the general rule that all nucleated cells produce eicosanoids. However, in a B lymphoma cell line, there is non-receptor-mediated uptake of LTB4 and 5-HETE. Interaction between lymphocytes and monocyte-macrophages may cause the lymphocytes to release arachidonic acid from their cell membranes. The arachidonic acid is then used by the monocyte-macrophages for eicosanoid synthesis. In addition to these cells, there is evidence for eicosanoid-mediated cell-cell interaction by platelets, erythrocytes, PMNs, and endothelial cells. 

Zhou ZH, Unlap T, Li L, Ma HP (2002) Incomplete inactivation of voltage-dependent K+ channels in human B lymphoma cells. J Membr Biol 188 97-105... 

Lundberg, B. B., Griffiths, G., and Hansen, H. J. (2004), Cellular association and cytotoxicity of anti-CD74-targeted lipid drug-carriers in B lymphoma cells,/. Controlled Release, 94,155-161. 

Armstrong JS, Hornung B, Lecane P, Jones DP, Knox SJ. 2001. Rotenone-induced G2/M cell cycle arrest and apoptosis in a human B lymphoma cell line PW. Biochem. Biophys. Res. Commun. 289 973-78... 

Griffiths GL, Mattes MJ, Stein R, et al. Cure of SCID mice bearing human B-lymphoma xenografts by an anti-CD74 antibody-anthracycline drug conjugate. Clin Cancer Res 2003 9 6567-65671. 

Virus-receptor interactions have also been shown to be affected by these ManN derivatives [154,155]. Treatment of human B-lymphoma BJA-B cells or African green monkey kidney epithelium cells with either ManProp, ManBut, or ManPent resulted in structural modification of about 50% of total cell surface sialic acids. Polyoma viruses, which use sialic acids as ligands for binding prior to infection, show either reduced or enhanced ability to infect cells carrying these modified sialic... 

Among the modes of myc activation are two modes (A3) involving rearrangement close to the gene retroviral insertion in the murine T and avian B lymphomas... 

Antitumor activity of Fab and IgG-anti-CD22 immunotoxins in disseminated human B lymphomas grown in mice with severe combined immunodeficiency disease effect on tumor cells in extranodal sites. Cancer Res. 51,5876-5880. 

Most of the information on DNA rearrangements in switched cells is derived from analysis of B cells that became transformed after switching. The transformation had immortalized the switched phenotype. With few exceptions, switching within transformed cell lines of the B lineage is a rare event. It has been observed in murine pre-B cell lines [27-29], human pre-B and B lymphomas [30], the murine B cell lymphoma 1.29 [31] and in several murine myeloma and hybridoma cell lines (e.g. [32]). In general, the frequencies of switching in these lines do not reflect the switch frequencies in the corresponding B cells from which they are presumed to be derived. 

There is evidence which supports the proposal that it may be possible to polyadenylate the primary IgH transcript at a membrane polyadenylation site and then subsequently cleave and polyadenylate at a secreted site. A small RNA has been described that is polyadenylated at the am polyadenylation site and that appears to have a 5 terminus close to the as site [127]. Similarly, an RNA has also been described which is polyadenylated at /j.m and contains the CmM exons but not the other exons of the /u. gene [156]. However, these RNAs have either been described in B lymphomas or in a T cell lymphoma/plasmacytoma hybrid but they have not been found - as one might more reasonably expect - in several immunoglobulin-secreting plasmacytomas analysed [127,155,156]. Therefore, the significance of sequential cleavage/polyadenylation in the generation of mRNA for the secreted form of IgH polypeptides remains unclear. 

Mohammad, R.M., Maki, A., Vistisen, K., and Al-Katib, A., 1994a, Protein smdies of human non-Hodgkin s B-lymphoma Appraisal by two-dimensional gel electrophoresis. Electrophoresis 15 1566-1572. 

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