B cell lymphoma protein

Bcl-2 B cell lymphoma protein 2 (Bcl-2) is a family of proteins that regulate apoptosis (programmed cell death). Apoptosis is a necessary process whereby aged or damaged cells are replaced by new cells. Dysfunction of the apoptosis process results in disease inhibition of apoptosis results in cancer, autoimmune disorder, and viral infection, whereas increased apoptosis gives rise to neurodegenerative disorders, myelodysplastic syndromes, ischemic injury, and toxin-induced liver disease. 

Bcl-10 B-cell lymphoma protein 10 mE10, CARMEN, CLAP, CIPER... 

Another strategy is to directly enhance dopamine function as well as the activities of B-cell lymphoma protein 2 (Bcl-2), which is another important component that may play a role, eventually, in the resolution of depression. Examples of various non-selective enhancers of dopamine that also stimulate Bcl-2 are pergolide, ropinirole, and selegiline, while pramipexole may directly enhance Bcl-2. The antidepressant effect exhibited by enhanced dopaminergic transmission is thought to be at least partially related to increased dopaminergic transmission in limbic structures (e.g. the nucleus accumbens). - ... 

BCL-2 Codes for a protein that blocks apoptosis Indolent B-cell lymphomas... 

As described in several monographs [4], bryostatin 1 exhibits significant in vitro and in vivo antineoplastic activity against a range of tumor cell lines including murine leukemia, B-cell lymphoma, reticulum cell sarcoma, ovarian carcinoma, and melanoma. It is also effective in the modulation of apoptotic function [5], the reversal of multidrug resistance [6], and stimulation of the immune system [7]. These unique features displayed by bryostatin 1 are attributed to its high affinity for protein kinase C (PKC) isozymes and its ability to selectively modulate their functions [8]. PKCs are a type of intracellular serine and threonine kinase that... 

Tumor surface Ig 38C13 scFv B-cell lymphoma treatment N. benthamiana TMV coat protein Rice a-amylase SP + 60 pg/mL of intercellular medium 56... 

Robertson Ml, Kahl BS, Vose JM, de Vos S, LaughUn M, Flynn PJ, Rowland K, Cruz JC, Goldberg SL, Musib L, Darstein C, Enas N, Kutok JL, Aster JC, Neuberg D, Savage KJ, LaCasce A, Thornton D, Slapak CA, Shipp MA. (2007) Phase II study of enzastaurin, a protein kinase C beta inhibitor, in patients with relapsed or refractory diffuse large B-cell lymphoma. J Clin Oncol 25 1741-1746. 

The Bcl-2 protein was first identified as an oncoprotein coded by a gene affected by translocations of chromosomes 14 and 18 in B cell lymphomas. It was soon shown, however, that the Bcl-2 protein is not involved in regulation of the cell cycle, in contrast to many other oncoproteins, and thus does not fit into the classical oncogene picture. Furthermore, homology was estabhshed with the Ced9 protein of C. elegans, which has an antiapoptotic function in this organism. 

A cancer research group with Abbott Laboratories and Idun Pharmaceuticals studied compounds that bind and inhibit the activity of Bcl-XL, a protein associated with B-cell lymphoma. The team developed compound 7.6 as a moderately active inhibitor of Bcl-XL (Figure 7.9). Compound 7.6, however, lost almost all its inhibitory activity when screened in the presence of human serum. The group determined that 7.6 binds domain III of human serum albumin (HS A-III) with a KD of 0.1 /U.M through two key interactions. The 4-fluorophenyl... 

Wendt, M. D Shen, W Kunzer, A., McClellan, W. J., Bruncko, M., Oost, T. K., et al. Discovery and Structure-Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity In Vitro and In Vivo. J. Med. Chem. 2006, 49, 1165-1181. 

In comparison to most other B cell lymphomas, MCL is relatively unique based on overexpression the cell cycle protein cyclin Dl, which can be identified immunophenotypically in the nuclei of the tumor cells in formalin-fixed paraffin tissue sections (B8, D3, K34, S30, S33, V7, Y4, Z4). The overexpression of the cyclin Dl protein is due to the characteristic genetic translocation found in MCL, t( 11 14), which juxtaposes heBCL-l (PRAD1, CYCLIN Dl) gene on chromosome 11 next to the immunoglobulin heavy-chain gene on chromosome 14 (R12, W7, W8). 

K28. Krenacs, L., Himmelmann, A. W., Quintanilla-Martinez, L., Fest, T., Riva, A., Wellmann, A., Bagdi, E., Kehrl, J. H., Jaffe, E. S., and Raffeld, M., Transcription factor B-cell-specific activator protein (BSAP) is differentially expressed in B cells and in subsets of B-cell lymphomas. Blood 92, 1308-1316(1998). 

Skinnider, B. E, Horsman, D. E., Dupuis, B., and Gascoyne, R. D., Bcl-6 and Bcl-2 protein expression in diffuse large B-cell lymphoma and follicular lymphoma Correlation with 3q27 and 18q21 chromosomal abnormalities. Hum. Pathol. 30, 803-808 (1999). 

---