Murine asthma

Ryman-Rasmussen, J.P. et al. (2009) Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma. American Journal of Respiratory Cell and Molecular Biology,... 

Matheson, J.M., Johnson, V.J., and Luster, M.I., Immune mediators in a murine model for occupational asthma studies with toluene diisocyanate, Toxicol. Sci., 84, 99, 2005. 

Janssen EM, van Oosterhout AJM, Nijkamp FP, van Eden W, Wauben MHM The efficacy of immunotherapy in an experimental murine model of allergic asthma is related to the strength and site of T cell activation during immunotherapy. J Immunol 2000 165 7207-7214. 

Taube C. Dakhama A, Gelfand EW Insights into the pathogenesis of asthma utilizing murine models. Int Arch Allergy Immunol 2004 135 173-186. 

Kim YS.KoHM, Kang Nl.etal Mast cells play a key role in the development of late airway hyperresponsiveness through TNF-oi in a murine model of asthma. Eur J Immunol 2007 37 1107-1115. 

Bryce PJ, Geha R, Oettgen HC Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. J Allergy Clin Immunol 2003 112 149-158. 

CTLA41g inhibits airway eosinophilia and hyperresponsiveness by regulating the development of Thl/Th2 subsets in a murine model of asthma. Am J Respir Cell Mol Biol 1998 18 453-462. 

Janssen EM. van Oosterhout AJ, van Rensen AJ. van Eden W. Nijkamp FP. Wauben MH Modulation of Th2 responses by peptide analogues in a murine model of allergic asthma amelioration or deterioration of the disease process depends on the Thl or Th2 skewing characteristics of the therapeutic peptide. J Immunol 2000 164 580-588. 

Yang X, Wang S, Fan Y, Han X IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction. Eur J Immunol 2000 30 382-391. 

Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW Histamine 4 receptor activation induces recruitment of FoxP3+ T ceUs and inhibits allergic asthma in a murine model. J Immunol 2007 178 8081-8089. 

Holgate ST (1999) The epidemic of allergy and asthma. Nature 402(Suppl 6760) B2-B4 Hoskin DW, Reynolds T, Blay J (1994a) Colon adenocarcinoma cells inhibit anti-CD3-activated killer cell induction. Cancer Immunol Immunother CII 38(3) 201-207 Hoskin DW, Reynolds T, Blay J (1994b) Adenosine as a possible inhibitor of killer T-cell activation in the microenvironment of solid tumours. Int J Cancer 59(6) 854-855 Hoskin DW, Reynolds T, Blay J (1994c) 2-Chloroadenosine inhibits the MHC-unrestricted cytolytic activity of anti-CD3-activated killer cells evidence for the involvement of a non-Aj/ A2 cell-surface adenosine receptor. Cell Immunol 159(1) 85—93 Hoskin DW, Buttler JJ, Drapeau D, Haeryfar SM, Blay J (2002) Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells. Int J Cancer 99(3) 386—395... 

Currently, 17 mAbs have been approved in the United States (US) for therapeutic use in organ transplant, percutaneous coronary intervention, prophylaxis of respiratory syncytial virus, RA, Crohn s disease, asthma, chronic lymphocytic leukemia (CLL), acute myeloid leukemia, non-Hodgkin s lymphoma, breast cancer, and colorectal cancer. All approved mAbs are of the IgG class 13 human IgG1 one igG4, and two murine IgG2a. Thirteen are intact mAbs, three are conjugated, and one is a Fab fragment (Tables 12.2 to 12.4). 

MDC is chemotactic for a number of cell types, including thymocytes, monocytes, IL-2-activated NK cells, dendritic cells, and both TH2 and CLA-t-T cells. In the context of pathophysiology the latter two activities are the most relevant. TH2 T cells are important mediators of allergic inflammation and MDC appears to play a role in the migration of this cell type in disease settings. MDC levels are elevated in the affected tissues in murine models of asthma (Gonzalo et al, 1999) and atopic dermatitis... 

MDC levels are significantly elevated in the serum of patients with diseases characterized by the activation of TH2 T cells and this is associated with local expression of MDC at disease sites (Galli et al, 2000). MDC expression has also been found to be elevated in a murine model of asthma (Gonzalo et al, 1999) and in a spontaneous mouse model of atopic dermatitis (Vestergaard et al, 1999). 

Neutralizing antibodies to MDC have been shown to block airway hyperreactivity in a murine model of asthma (Gonzalo et al, 1999). 

Lukacs, N.W., Strieter, RM., Chensue, S.W. and Kunkel, S.L. Interleukin-4-dependent pulmonary eosinophil infiltration in a murine model of asthma. Am. J. Respir. Cell Mol. Biol. 10, 526-530. 

MDC (CCL22) and TARC (CCL17) (see Table 4.1). The role of the mouse ligand analogs has been studied in murine models of asthma. In ovalbumin-sensitized and -challenged mice. 

Respiratory disease Alveolar macrophages synthesize lipoxins Reduced levels of endogenous lipoxin observed in asthma and COPD LX administration to a murine model of asthma blocked airway hyper-responsiveness and pulmonary inflammation Kim et al. 1988 Vaichier et al. 2005 Levy et al. 2002... 

Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV, Thorne PS, Krieg AM Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol 1998 160 2555-2559. 

Omalizumab is the first anti-IgE antibody approved for the treatment of asthma not well controlled on high doses of ICSs. Omalizumab is a composite of 95% human and 5% antihuman murine IgE sequences. The mouse protein becomes part of the receptor complex and thus is shielded from exposure to the immune system and presents a low risk for an anaphylactic response. ... 

Itami DM, Oshiro TM, Araujo CA, Perini A, Martins MA, Macedo MS, Macedo-Soares ME (2005) Modulation of murine experimental asthma by Ascaris suum components. CUn Exp ADergy 35(7) 873-879... 

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