Processes, disease

The process of target identification analyzes a complex disease process by dissecting it into its fundamental components. This makes it possible to identify the one that is most integral to the manifestation of the disease. Target identification aims to understand the biological processes related to a disease, and to identify its mechanism and the structure of individual elements of the disease. Commonly these individual elements are receptors, enzymes, etc., which become the target of new drugs. 

The biodistribution of the ideal radiopharmaceutical would show extremely rapid distribution via the circulatory system to the organs of interest and htfle distribution to others. It would be rapidly extracted by the organ or tissue of interest differentially in a way that reflects the disease process of interest. Ideally, abnormahties should be defined by substantial increases in the concentration of the agent because lesions defined by a decrease from surrounding concentrations, ie, cold-spot imaging, are more difficult to image. 

Additionally, the electrophysiological effects are often obtained from normal myocardial preparations and the abnormalities of cellular electrophysiology which cause arrhythmias in a diseased myocardium may be uniquely related to the disease process (10). Nevertheless, antiarrhythmic agent classifications have been useful as a mnemonic device. 

The use of synthetic organic chemistry to create molecules that will alter in a useful way some disease process in a living system. 

Rational drug design is the ultimate goal of medicinal chemistry. By this is understood the design of medicinal agents on the basis of knowledge of the intimate biochemistry of the disease process. 

An alternative approach involves testing of new drug entities on whole-cell systems and measuring effects on integrated cellular pathways. Favorable phenotypic responses are identified with this approach that may better produce alteration of multicomponent disease processes. 

A disease process characterized by deterioration of the macula of the retina that results in a loss of shaip central vision. AMD is the leading cause of central vision loss in the developed countries today for those over the age of fifty years. 

A gene activity profile is a collection of quantitatively determined levels of gene products, found in one tissue or cell type, which is characteristic of the tissue, a disease process, a hormone response, a pharmaceutical intervention, etc. 

Increasing spatial and to some extent also contrast resolution of X-ray equipment and advances in the understanding of disease processes are in favor of improved X-ray contrast agents which provide important additional information. 

Teach patient/family about drug, disease process, treatment regimen, etc. 

Assess knowledge of disease process, drug, and drug regimen.]... 

A patient must have motivation (having the desire or seeing the need) to learn. Motivation depends on the patient s perception of the need to learn. Education concerning the disease process may be necessary for the patient to become motivated to learn. Encouraging patient participation in planning realistic and attainable goals also promotes motivation. If the patient has no motivation, he or she is likely to be noncompliant. 

Deficient Knowledge related to the drug regimen, possible adverse reactions, disease process, other factors... 

The therapeutic effect is achieved and symptoms of disease process subside or diminish. 

Risk for Imbalanced Nutrition Less Than Body Requirements related to adverse drug reactions or disease process (malaria)... 

Risk for Injury related to an adverse drug reaction (eg, dizziness, syncope, dumsiness) or disease process... 

Carry an identification card describing the disease process and your medication regimen. 

Decreased Cardiac Output related to adverse reactions or disease process... 

The foundation for the more rational approach to drug discovery that is practised today comes from basic research into disease processes and medical conditions. Much of this research is carried out in universities and other research institutions, with funding coming from both government and pharmaceutical industry sponsors. 

The first issue lies in the whole realm of the human disease process itself. Many adverse drug events mimic diseases and vice versa. Is an adverse event really an adverse event, or is it merely a natural occurrence of a disease process that is entirely independent of drug exposure The science of drug safety is often complicated by the lack of objective markers of drug toxicity that can systematically separate a disease process from an adverse drug event process [2]. Clinical trials, often viewed as the gold standard to assess efficacy, are simply too limited in scope to answer safety questions in a systematic way. 

Leukotrlenes LIpoxIns Are Potent Regulators of Many Disease Processes... 

Phospholipids and sphingolipids are involved in several disease processes, including respiratory distress syndrome (lack of lung surfactant), multiple sclerosis... 

To carry on an active program in research and development in order to improve the procedures for the understanding and the diagnosis of the disease process in the newborn. 

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