Tumors transplanting

Tumor transplantation to determine whether acrylonitrile is genotoxic i n the rat... 

The results obtained in tumors transplanted into an animal model were similar, showing greater potency and longer lasting effects for treatment with edotecarin than with SN-38. 

Arakawa H, Morita M, Kodera T, Okura A, Ohkubo M, Morishima H, et al. In vivo anti-tumor activity of a novel indolocarbazole compound, J-107088, on murine and human tumors transplanted into mice. Jpn. J. Cancer Res. 1999 Oct 90(10) 1163-70. 

Geiger T, Muller M, Dean NM, Fabbro D (1998) Antitumor activity of a PKC-alpha antisense oligonucleotide in combination with standard diemotherapeutic agents against various human tumors transplanted into nude mice. Anticancer Drug Des 13 35-45... 

No rodent bioassay Tumor promotion potential was evaluated by first identifying human tumor cell lines that bind natalizumab in vitro Tumor promotion potential was then evaluated by assessing tumor growth in athymic nude mice after tumor transplantation (sc) followed by treatment with natializumab. Natalizumab did not show any tumor promoting potential on two oc4 expression tumors (leukemia, melanoma) in a nude mouse xenograft model Not genotoxic (Ames, in vitro chromosomal aberrations in human PBLs)... 

Shapiro WR, Basler GA, Chernik NL, Posner JB. Human brain tumor transplantation into nude mice. J Natl Cancer Inst 1979 62 447-53. 

One of the most important questions concerning the antitumor effect of these polysaccharides is whether they can inhibit the growth of autochthonous tumors. Transplanted tumors, be they syngeneic or allogeneic, are artifacts produced in the laboratory, and are not necessarily truly comparable with tumors that arise spontaneously within the body of the host (autochthonous tumors). 

Polycythemia rubra vera Renal vascular disorders Severe anoxia Snake bite Solid tumors Transplant rejection... 

Corticosteroids are used in clinical practice to relieve pressure symptoms caused by many tumor types, notably intracerebral tumors but also those causing airway or central venous obstruction. Their mode of action has been studied in animals (57) and humans (58), and is thought to involve first constriction of tumor vascular volume and then a reduction in water content. Reduced interstitial pressure should increase perfusion and extravascular diffusion rates, and high doses of steroids have been shown to increase blood flow in human colonic tumors transplanted into mice. Uptake of antibody into tumors has been assessed before and after administration of high-dose dexamethasone to decrease tumor interstitial pressure and thus increase antigen accessibility. Three patients with recurrent colorectal carcinoma had two antibody scans each, 72 h apart, and the injected dose was the same for all scans (20 mg). Dexamethasone was started 24 h before the second dose of antibody, with an initial iv dose of 10 mg followed by 4 mg four times daily orally for 48 h. 

Gasa, S., Makita, A., Kameya, T., Kodama, T., Koide, T., Tsumuraya, M., and Komai, T., Arylsul tases of human-lung tumors transplanted into alythmic mice—Cancer assoeiated modification of arylsulfatase B variant. Eur. J. Biochem. 116, 497-503 (1981). 

Studies on the structure-activity relation of the metallocene dihalides were generally performed using as experimental system the Ehrlich ascites tumor (EAT) growing in female CF1 mice. The therapeutic effect was judged by determining the mean survival time (MST) and by calculating the increase in life span (ILS) compared to the untreated controls. The key-date for the survival studies was day 180 after tumor transplantation (Table I, III) or day 60 (Table VIII). 

Ph a) Day after tumor transplantation on which the animals were ... 

See Figure 2 for structures. Data adapted from references 10 and 23. All compounds were dissolved in NaCl 0.9% and further diluted in complete culture medium. ICjo is Inhibiting Concentration 50% of cellular growth after 48 h of drug exposure. Mean of 198 experiments. 10 cells i.p. into CD2F1 male mice. Treatment i.p. on days 1,5,9 after tumor transplantation (day 0). All compounds were dissolved in saline just before use. T/C median survival time of treated mice/median survival time of controls x 100. 

Sylven. B. Lysosomal enzyme activity in the interstitial fluid of solid mouse tumor transplants. Eur. J. Cancer. 4 463-474.1968. Szent-Gydrgyi. A. Observations of the functions of peroxidase systems and the chemistry of the adrenal cortex. Biochem. J.. 22 1387-1409, 1928. 

Polysaccharides were administered i.p. daily for 10 days, starting 24 h after tumor transplantation and the inhibition ratios of tumor-growth were calculated after 5 weeks. ... 

Figure 12.2 Survival of mice 30 days after tumor transplantation and 29 days after treatment with Cp2TiCl2 at the doses given on the abscissa [39]. M, tumor deaths without signs of substance toxicity. Deaths caused by toxicity (deaths after 8 days after transplantation without macroscopically visible tumor development). , Animals surviving on the 30th day after transplantation (therapeutic range)...

The triphasic response to selenium is similar in fact to antigenic stimulation of tumor transplants. The dose response effect of Se when added to the diets of mice or guinea pigs for immune enhancement appears to be 1-2 ppm as indicated by the PFC assay performed with mice and the DNCB challenge of guinea pigs. When selenium is administered by injection, the immune response is measured by the hemagglutination titers and is dose related as well... 

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