Applications to quality control

TMA has mainly been used in the study of polymers. The mechanical properties study may be used to characterize a polymer as well as to assess its mechanical utility. There is an obvious application to quality control. The ability to study small specimens gives the technique a distinct advantage over more traditional methods of mechanical testing if sample size is limited. A typical TMA study has already been exemplified in Figure 11.19. 

There are many GC detectors available although the flame ionisation detector remains the most widely used and the most widely applicable to quality control of pharmaceutical products. However, newer detectors such as the plasma emission detector for analysis of trace impurities or the GC-FTIR detector for the structural characterisation of components in mixtures are becoming increasingly important. 

Valentao, P. et al.. Analysis of vervain flavonoids by HPLC/diode array detector method. Its application to quality control, J. Agric. Food Chem., 47, 4579, 1999. 

Sarri, A.K., Megoulas, N.C., and Koupparis, M.A. Development of a novel liquid chromatography evaporative light scattering detection method for bacitracins and applications to quality control of pharmaceuticals. Anal. Chim. Acta 2006, 573,... 

The methods also have application to quality control and routine analysis. Samples can be studied with reasonably rapid turnover. Once established on an authentic sample, the gas product distribution is frequently characteristic and distinguishable among various materials. Hence, Fast Thermolysis/FTIR has broad applications extending beyond the study of energetic materials. Its commercial availability will make advances possible in a wide range of applications in the future. 

R 303 B. Bluemich, S. Anferova, F. Casanova, K. Kremer, J. Perlo and S. Sharma, Unilateral NMR Principles and Applications to Quality Control of Elastomer Products , KGK, Kaut.Gummi Kunstst., 2004,57,346 R 304 PJ. Bond and M.S. Sansom, The Simulation Approach to Bacterial Outer Membrane Proteins (Review) , Mol.Membr.Biol., 2004,21,151 R 305 N. Borkakoti, Matrix Metalloprotease Inhibitors Design from Structure , Biochem.Soc.Trans., 2004,32,17... 

Contaminant concentrations Dispersal of airborne contaminants such as odors, fumes, smoke, VOCs, etc. transported by these airflows and transformed by a variety of processes including chemical and radiochemical transformation, adsorption, desorption to building materials, filtration, and deposition to surfaces evolution of contaminant concentrations in the individual zones air quality checks in terms of CO2 levels cross-contamination evaluation of zones air quality evaluations in relation to perception as well as health. Methods ate also applicable to smoke control design. 

Immunoglobulins in the form of monoclonal antibodies are manufactured commercially for therapeutic and diagnostic uses. Major areas of consideration in these applications are quality control and bioactivity. Separation of immunoglobulins has proven to be a challenge even for well-established techniques such as HPLC. Difficulties arise due to the large size of antibodies and their surface properties, which increase their tendency to interact with proteins and matrix. 

Unlike other methods currently employed for quantitative transcript measurements, including cDNA microarrays and real-time RT-PCR, competitive RT-PCR is amenable to quality control, which is critical for clinical diagnostic and pharmaceutical industry applications. Furthermore, microarray approaches are limited to generating snap-shot like profiles, but they do not control for differences in hybridization efficiencies of different gene probes with their corresponding cDNAs. That is, cross comparisons are relative and not absolute. Real-time PCR has gained acceptance recently largely due to the reduced cost associated... 

Natural products, from plants and foods to rocks and minerals, are complicated systems, but their analysis by Raman spectroscopy is a growing area. Most examples come from quality control laboratories, motivated to replace current time-consuming sample preparation and analysis steps with a less labor-intensive, faster technique but most authors anticipated the eventual application to process control. Often a method will be practiced in a trading house or customs facility to distinguish between items perceived to be of different qualities, and thus prices. 

The emphasis of the current research is on molecular structure of oligomeric fractions leached from quality cured, industrial resins. However, the potential for applications in quality control should not be overlooked. Chromatography analysis provides positive feedback capable of molecular descriptions of extent of cure actually achieved. Oligomeric distributions coupled to kinetic reaction analysis allows for detailed estimates of crosslink architecture within the resin (7). 

Spectral imaging is a complex and multidisciplinary field. The introduction of new FPAs is making it increasingly powerful and attractive. It has proven potential in qualitative pharmaceutical analysis and can be used when spatial information becomes relevant for an analytical application. Even if online applications and regulatory method validation require further study, the potential contribution of imaging to quality control and PAT needs no further demonstration. 

Antoon, M. K., Starkey, K. M., Koenig, J. L. Applications of Fourier Transform Infrared Spectroscopy to Quality Control of the Epoxy Matrix, Composite Materials, Fifth Conference, ASTM, p. 541, 1979... 

The taste sensor will be applicable for quality control in food industry and help automation of the production. The sense of taste is vague and largely depends on subjective factors of human feelings. If we compare the standard index measured by means of the taste sensor with the sensory evaluation, we will be able to assess taste objectively. Moreover, the mechanism of information processing of taste in the brain as well as the reception at taste cells will also be clarified by developing a taste sensor which has output similar to that of the biological gustatory system. 

Applications of Capillary Zone Electrophoresis to Quality Control... 

The use of 2,7-dimethyl-3,8-dinitrodipyrazolo[l,5-a,l, 5 -d]pyrazine-4,9-dione - a new labeling reagent for liquid chromatographic analysis of amino acids - is offered [671], Application of the method to quality control of commercially available oral polyaminoacid formulations is described. 1,2-1 ii acetyl -4,4-di n i (ropyrazol idi ne and products of its further nitration have been obtained [672],... 

Recent developments in the technique have made it amenable for everyday use in pharmaceutical research and development. This article contains examples of how SSNMR can be used to solve pharmaceutical problems, along with specific applications from the literature. It is the authors opinion that SSNMR will eventually become an integral part of the pharmaceutical laboratory, from discovery to quality control. 

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