Antitumor activity in mice

Methotrexate-7-Hydrazide and Divinyl Ether—Maleic Anhydride Conjugate Antitumor Activity in Mice... 

The conjugation of deacetylvinblastine to a monoclonal antibody that recognizes a tumor-associated antigen results in an agent with substantial antitumor activity in mice with relatively little toxicity (la). Conjugates of this type are of obvious interest for future clinical trials as site-directed cancer chemotherapeutic agents. 

Hybrid and Consensus IFNs. After the sequences of all IFN-a subtypes and their activities were deduced, recombinant hybrids were designed to improve the activity of natural subtypes. It is possible to radically change the properties of an IFN by making hybrids. For example, a hybrid made from the first 61 amino-acid residues of IFN-al and the last 104 amino-acid residues of IFN-a2 exhibited high antiviral activity on mouse cells, while another hybrid produced from the first 91 amino-acid residues of IFN-al and the last 72 amino-acid residues of IFN-a4 had no antiviral effect but displayed enhanced antitumor activity in mice, a property neither of the parent molecules exhibit. Structure-function analysis of hybrid molecules has indicated that the NH2 terminus portion of the IFN-a molecule is important for its biological activity [46]. 

A pivotal feature of the preclinical lead discovery process for identifying orally active platinum complexes was a comparison of antitumor activity in mice bearing the ADJ/PC6 subcutaneous murine plasmacytoma by the oral vs. intraperitoneal (i.p.) routes of administration. The ADJ/PC6 tumor model had been widely used in earlier platinum drug development pro-... 

Table. Intraperitoneal vs. Oral Antitumor Activity in Mice Bearing the ADJ/PC6 Plasmacytoma for Selected Platinum Agentsa)...

After the formulation of the antimetabolite theory by Woods and Fildcs in 1940,antimetabolites based on a variety of known nutrients were prepared. The first purine analogue to show antitumor activity in mice. 8-azaguanine. was synthesized by Roblin in I94. i. This compound was intro-... 

Besides peptides that are presented by MHC molecules to prime/activate T cells, there is another family of peptides responsible for immune response modulation and rejection of tumor cells. Alloferon 1 (HGVSGHGQHGVHG), a peptide isolated from the hemolymph of experimentally infected insect Calliphora vicina, showed an antiviral and antitumor activity in mice. Although immunomodulatory properties of the peptide remain to be clarified in detail, it is suggested that alloferon 1 has a significant capacity to stimulate NK cell activity and IFN synthesis in murine and human models [334]. 

Gabizon A, Dagan A, Goren D, Barenholz Y, Fuks Z (1982) Liposomes as in vivo carriers of adriamycin reduced cardiac uptake and preserved antitumor activity in mice. Cancer Res 42 4734 739... 

We have recently shown (unpublished data) the antitumor activity in mice and the gonotoxic effect of a fraction isolated from methanol extract of saffron, that had been purified on a silica gel column using chloroform/methanol as eluent. P388 tumor cells were transplanted in... 

Adachi, K., Nanba, H., and Kuroda, H., Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake), Chem. Pharm. Bull. (Tokyo), 35, 35262-35270,1987. 

Masui H, Moroyama T, Mendelsohn J. Mechanism of antitumor activity in mice for anti-epidermal growth factor receptor monoclonal antibodies with different isotypes. Cancer Research 1986 46 5592-5598. 

Polysyncraton lithostrotum. 1 mg was obtained from 1 kg of tissue. N. exhibits strong in vitro cytotoxicity with a mean ICjo of 3.5 ng/mL and in vivo antitumor activity in mice (P388 leukemia model) with ED40 3 Mg/kg. 

Iga K, Hamaguchi N, Igari Y, Ogawa Y, Gotoh K, Ootsn K, et al. Enhanced antitumor activity in mice after administration of thermosensitive liposome encapsulating dsplatin with hyperthermia. J Pharmacol Exp Ther 1991 257 1203-7. 

Tanshinones showed a broad spectrum of cytotoxic effects on cell lines derived from human carcinomas of the colon, ovary, lung, mouth, and breast [3, 38, 39] (Table 117.1). The mode of action (MoA) for antitumor activity has been studied for different tanshinones. Tan-1 (1) and llA (11) have been studied efficiently for their cytotoxic activity and induced differentiation and apoptosis [45, 46], Przewaquinones A (24) and B (2) showed promising antitumor activity in mice [47]. This section will outline antitumor activity of tanshinones, especially Tan-1, Tan-IIA, and neo-tanshinlactones in vitro and in vivo, and their MoA. 

Y. Kimura, and H. Okuda, Prevention by chitosan of myelotoxicity, gastrointestinal toxicity and immunocompetent organic toxicity induced by 5-fluorouracil without loss of antitumor activity in mice, Jpn. J. Cancer Res., 90 (7), 765-774,1999. 

Naganuma A, Satoh M, Imura N (1987) Prevention of lethal and renal toxicity of cis-diamminedichloroplatinum(II) by induction of metallothionein synthesis without compromising its antitumor activity in mice. Cancer Res 47 983-987 Naganuma A, Satoh M, Imura N (1988) Specific reduction of toxic side effects of adriamycin by induction of metallothionein in mice. Jpn J Cancer Res 79 406-411... 

In the evaluation of a number of studies, Saxena and Huber found that the most active organotin species were the dialkyltin compounds. Brown found that triphenyltin acetate exhibited antitumor activity in mice, while triphenyltin chloride was inactive. She believed that the degree of water solubility was an important factor in the anticancer activity of the organotin compounds. 

Gu DL, Gonzalez AM, Printz MA, Doukas J, Ying W, D Andrea M, Hoganson DK, Curiel DT, Douglas JT, Sosnowski BA, Baird A, Aukerman SL, Pierce GF. Fibroblast growth factor 2 retargeted adenovirus has redirected cellular tropism evidence for reduced toxicity and enhanced antitumor activity in mice. Cancer Res 1999 59 2608-2614. 

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