Thermosensitive liposomes

Chiu GN, Abraham SA, Ickenstein LM, et al. Encapsulation of doxorubicin into thermosensitive liposomes via complexation with the transition metal manganese. J Control Release 2005 104 271. 

Fig. 12. Thermosensitive liposomal MRI contrast agent as described by Fossheim et al. [103]...

Aoki, H., et al. 2004. Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome Evaluation of drug distribution in a rat glioma model. Int J Hyperthermia 20 595. 

In a human tumor xenograft model, Kong et al.21 compared the antitumor effect of doxorubicin encapsulated in three types of liposome formulations, a nonthermosensitive liposome (NTSL), a traditional thermosensitive liposome (TTSL), and a low-temperature-sensitive liposome (LTSL). All three liposomes are sterically stabilized with PEG grafted on their surface. All the liposomes have a long circulation time and can accumulate selectively in tumor tissue. However, the lipid compositions of the three formulations are different. The NTSL was composed of saturated long-chain lipids such as hydrogenated soybean... 

Bochot, A., Fattal, E., Gulek, A., and Aonarraze, G. (1998), Liposome dispersed within thermosensitive gel. A new dosage form for ocular delivery of oligonucleotide, Pharm. Res., 15,1364-1369. 

Aoki, H., Kakinuma, K., Morita, K., Kato, M., Uzuka, T., Igor, G, Takahashi, H., and Tanaka, R. (2004), Therapeutic efficacy of targeting chemotherapy using local hyperthermia and thermosensitive liposome Evaluation of drug distribution in a rat glioma model, Int. J. Hypertherm., 20, 595-605. 

Kono, K. (2001), Thermosensitive polymer-modified liposomes, Adv. Drug Deliv. Rev., 53,307-319. 

Bochot A, Fattal E, Gulik A, et al. Liposomes dispersed within a thermosensitive gel a new dosage form for ocular delivery. Pharm Res 1998 15 1364-1369. 

Chen, Q. Tong, S. Dewhirst, M. W. Yuan, F. Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. Mol. Cancer Then 2004, 3, 1311-1317. 

Kono K, Henmi A, Takagishi T. Temperature-controlled interaction of thermosensitive polymer-modified cationic liposomes with negatively charged phospholipid membranes. Biochim Biophys Acta 1999 1421 183-197. 

Puri, A., Kramer-Marek, G., Campbell-Massa, R., 2008. HER2-specific affibody-conjugated thermosensitive liposomes (Affisomes) for improved delivery of anticancer agents. J. Liposome Res. 18 (4), 293—307. 

Thermosensitive liposomes are made from phospholipids whose membrane undergoes the gel-to-liquid crystalline phase transition a few degrees above physiological temperature. Increasing the temperature of a mmor s cells using an external source may induce drug release from thermosensitive liposomes at the tumor site [17,18], It has been recently shown that when certain copolymers incorporate in liposome bilayers, the vesicles become thermosensitive and the tumor targeting is enhanced upon induction of hyperthermia [19],... 

Iga K, Hamaguchi N, Igari Y, Ogawa Y, Gotoh K, Ootsn K, et al. Enhanced antitumor activity in mice after administration of thermosensitive liposome encapsulating dsplatin with hyperthermia. J Pharmacol Exp Ther 1991 257 1203-7. 

Kono K, Ozawa T, Yoshida T, Ozaki F, Ishizaka Y, Maruyama K, et al. Highly temperature sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy. Biomaterials 2010 27 7096-105. 

Gene, R., Murphy, D., Fragoso, A., Ortiz, M., O Sullivan, C. K. Signal-enhancing thermosensitive liposomes for highly sensitive immunosensor development. Anal. Chem. 83, 563-570 (2011)... 

Thermosensitive HPMA mono/dilactate polymer was prepared and the temperature-triggered release of content from polymer-coated liposomes studied. HPMA mono/ dilactate polymer was synthesized with a cholesterol anchor suitable for incorporation in the liposomal bilayers and with a cloud point temperature of the polymer slightly above normal body temperature (42°C)... 

A separate group of smart pol5miers is represented by particulate systems. Liposomes that reversibly precipitate on salt addition and removal were prepared from a synthetic phospholipid that had a diacetylene moiety in the hydrophobic chain and an amino group in the hydrophilic head of the phospholipid, followed by polymerization of diacetylene bonds (35). Latices composed of thermosensitive polymers or a layer of thermosensitive polymer at the surface represent another example of insoluble but reversibly suspended particulate systems that respond to increasing/decreasing temperature (31). 

Smart particles capable of reversible transition between aggregated and dispersed states were used for affinity precipitation of proteins. Thermosensitive (44) or pH-sensitive latices (45) or salt-sensitive liposomes that have polsrmerized membranes (35) are examples of such systems. 

The reversible flocculation of latices has been used to produce thermosensitive reversibly soluble (more precisely reversibly dispersible) biocatalysts using trypsin (129), papain (130), and a-amylase (131). Latices sensitive to a magnetic field have been used to immobilize trypsin and j0-galactosidase (132). Liposomes that have a polymerized membrane reversibly aggregate on changing salt concentration and have been used to immobilize a-chymotiypsin (133). 

Kono K, Nakai R, Morimoto K et al. Thermosensitive polymer-modified liposomes that release contents around physiological temperature. Biochim Biophys Acta 1999 1416 239-250. 

Hayashi H> Kono K, Takagishi T. Temperature-dependent associating property of liposomes modified with a thermosensitive polymer. Bioconju te Chem 1998 9 382-389. 

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