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Antisense inhibition

Good L., Nielsen P.E. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nature Biotech-nol. 1998 16 355-358. [Pg.174]

Neckers, L., Whitesel, L., Rosolen, A., and Geselowitz, D.A., Antisense inhibition of oncogene expression, Critical Reviews in Oncogenesis, 1992, 3, 175-231. [Pg.16]

To, R. Y., and Neiman, RE., The potential for effective antisense inhibition of retroviral replication mediated by retroviral vectors. In Erickson R.P., Izant J.G., eds., Gene Regulation Biology of Antisense RNA and DNA. Raven Press, New York, 1992, pp. 261-271. [Pg.16]

TAUBERGER, E., FERNIE, A.R., EMMERMANN, M., KOSSMANN, J., WILLMITZER, L., TRETHEWEY, R.N., Antisense inhibition of plastidial phosphoglucomutase provides compelling evidence that potato tuber amyloplasts import carbon from the cytosol in the form of glucose-6-phosphate, Plant J., 2000, 23, 43-53. [Pg.78]

Lev-Lehman, E., Ginzberg, D., Homreich, G., Ehrlich, G., Meshorer, A., Eckstein, E., Soreq, H., and Zakut, H. (1994) Antisense inhibition of acetylcholinesterase gene expression causes transient hematopoietic alterations in vivo. Gene Therapy 1, 127-135. [Pg.400]

Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S (1997) Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2. Mol Pharmacol 52 1000-1009 Wang XY, Repasky E, Liu HT (1999a) Antisense inhibition of protein kinase C alpha reverses the transformed phenotype in human lung carcinoma cells. ]q> Cell Res 250 253-263... [Pg.93]

HeiligM (1995) Antisense inhibition of neuropeptide Y (NPY)-Y 1 receptor expression blocks the anxiolytic-like action ofNPY in amygdala and paradoxically increases feeding. Regul Pept 59 201-205... [Pg.361]

Van der Meer, l.M. et al., Antisense inhibition of flavonoid biosynthesis in Petunia anthers results in male sterility, Plant Cell, 4, 253, 1992. [Pg.435]

Ghelardini, C., Galeotti, N., Bartolini, A. Loss of muscarinic antinociception by antisense inhibition of M1 receptors, Br. J. Pharmacol. 2000, 129, 1633-1640. [Pg.452]

Stein, C.A. and Cheng, Y.C. (1997) Antisense inhibition of gene expression. In V.T.De Vita, S.Hellman and S.A.Rosenberg (eds) Cancer Principles and Practice of Oncology, Lippincott-Raven, Philadelphia, pp. 3059-3074. [Pg.48]

A PK/PD relationship in humans has recently been reported for a novel hypolipidemic agent, ISIS 301012, a 2 -MOE partially modified antisense inhibitor of human apoB-100 [59, 64]. ApoB-100 is a structural component of LDL-cholesterol, and plays a key role in its metabolism and transport Prefiminary data from this study indicate that antisense inhibition of apoB-100 results in both dose- and concentration-dependent sustained reductions in serum levels of apoB-100, LDL-cho-lesterol and total cholesterol, but does not affect levels of HDL-cholesterol. [Pg.114]

T. Sharp, and P.J. Harrison. 1997. Critical issues in the antisense inhibition of brain gene expression in vivo experiences targetting the 5-HT1A receptor. Neurochem. Int. 31 349-362. [Pg.267]

The last remaining question is if AVI-4126 will find a place in future therapeutic regimens for the prevention of restenosis this answer might be found in the results of phase II clinical studies currently being conducted, such as AVAIL. Our recent data on six-month follow-up on the patients enrolled in the AVAIL study (87) showed that AVI-4126 is effective in reducing neointimal formation, particularly when locally delivered in high dose. We also concluded that local delivery of antisense is safe and feasible, The results indicate that antisense (AVI-4126) can be as effective in prevention of the restenosis as most of the well-known antiproliferative agents do, but in contrast to other chemotherapeutics (paclitaxel, actinomycin D) c-myc antisense inhibits cell cycle in the G-1 phase, which make its effect less toxic and comparable with that of rapamycin. [Pg.377]

Sibille E, Samyai Z, Benjamin D, Gal J, Baker H, Toth M. Antisense inhibition of 5-hydroxytryptamine2a receptor induces an antidepressant-like effect in mice. Mol Pharmacol 1997 52(6) 1056-1063. [Pg.566]

Antisense inhibition of RNA function requires the inhibition of thousands of copies of the target RNA present in the cell. However, inhibition of transcription at the level of DNA requires the inactivation of transcription from only one or two active copies of a gene present in the genome this is the rationale for... [Pg.212]

Deng W, Li R, Guerrera M, Liu Y, Ladisch S. Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation. Glycobiology 2002 12 145-152. [Pg.634]

Braasch DA, Liu Y, Corey DR. Antisense inhibition of gene expression in cells by obgonucleotides incorporating locked nucleic acids effect of mRNA target sequence and chimera design. Nucleic Acids Res. 2002 30 5160-5167. [Pg.1672]

Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of pradrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation 2000 101 682-688. [Pg.334]

Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 108 1833. [Pg.125]

The results of experiments In which active myosin II is eliminated from the cell demonstrate that cytokinesis is indeed dependent on myosin II (Figure 19-21). In one type of experiment, antl-myosin II antibodies are microinjected into one cell of a sea urchin embryo at the two-cell stage. In other experiments, expression of myosin II Is Inhibited by deletion of the myosin gene or by antisense Inhibition of myosin mRNA expression. In all cases, a cell lacking myosin II replicates to form a multinucleated syncytium because cytokinesis, but not chromosome separation, Is Inhibited. Without myosin II, cells fail to assemble a contractile ring, although other events in the cell cycle proceed normally. [Pg.796]

Zhang H, Goodman HM and Jansson S (1997) Antisense inhibition of the Photosystem I antenna protein Lhca4 in Arabidopsis thaliana. Plant Physiol 115 1525-1531... [Pg.291]

Carrier peptides represent another interesting class of molecules to which PNA has been conjugated. These peptides have been found to traverse the cell membrane and are capable of actively transporting attached constructs [50]. PNA conjugated to these biomolecules by a disulfide linkage has been shown to be internalized in the cytoplasm and dissociated from the carrier peptides, presumably by reduction of the linkage. These internalized PNAs have demonstrated antisense inhibition of messenger RNA in the model systems studied. [Pg.575]

Most similar to RNAi compounds in their application and chemical nature are antisense compounds one of which, Vitravene, reached the market as an FDA-approved drug in 1998 [194,195]. Antisense oligonucleotides have been studied for their ability to knock down gene expression since 1978 [196, 197]. Later studies support that the mechanism of antisense inhibition acts either through the inhibition of translation or through RNase H-dependent degradation of mRNA [198]. [Pg.1135]


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See also in sourсe #XX -- [ Pg.244 , Pg.311 ]




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