Acetylcholinesterase genes

Taylor P, Li Y, Camp S, et al. 1993. Structure and regulation of expression of the acetylcholinesterase gene. Chem Biol Interactions 87 199-207. 

Grauso, M., Culetto, E., Combes, D., Fedon, Y., Toutant, J.-P. and Arpagaus, M. (1998) Existence of four acetylcholinesterase genes in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. FEBS Letters 424, 279-284. 

Lev-Lehman, E., Ginzberg, D., Homreich, G., Ehrlich, G., Meshorer, A., Eckstein, E., Soreq, H., and Zakut, H. (1994) Antisense inhibition of acetylcholinesterase gene expression causes transient hematopoietic alterations in vivo. Gene Therapy 1, 127-135. 

Bentley, C.N., Jones, A.K. and Agnew, A. (2003) Mapping and sequencing of acetylcholinesterase genes from the platyhelminth blood fluke Schistosoma. Gene 314, 103-112. 

Damodaran T.V., Jones, K.H., Patel, A.G., Ahou-Donia, M.B. (2003). Sarin (nerve agent GB)-induced differential expression of mRNA coding for the acetylcholinesterase gene in rat central nervous system. Biochem. Pharmacol. 65 2041-7. 

Evron, T., Greenberg, D., Mor, T.S., Soreq, H. (2007). Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults. Toxicology 233 97-107. 

Mis, K., Mars, T., Golicnik, M., Jevsek, M., Gmbic, Z. (2006). Effects of acetylcholinesterase gene silencing on its activity in cultured human skeletal muscle. J. Mol. Neurosci. 30 31-2. 

Chan, R.Y., Boudreau-Lariviere, C., Angus, L.M., Mankal, F.A., Jasmin, B.J. (1999). An intronic enhancer containing an N-box motif is required for synapse- and tissue-specific expression of the acetylcholinesterase gene in skeletal muscle fibers. Proc. Natl Acad. Sci. USA 96 4627-32. 

Li, Y., Camp, S., Taylor, P. (1993). Tissue-specific expression and alternative mRNA processing of the mammalian acetylcholinesterase gene. J. Biol. Chem. 268 5790-7. 

A. is sometimes called true cholinesterase in contrast to relatively unspecific acylcholinesterases (see Cholinesterase). [D.K.Getman etal. Tlanscriptional Factor Repression and Activation of the Human Acetylcholinesterase Gene J. Biol. Chem. 270 (1995) 23511-23519]... 

Soreq, S., Patinkin, D., Lev-Lehman, E., et al., 1994. Antisense oligonucleotide inhibition of acetylcholinesterase gene expression induces progenitor cell expansion and suppresses hematopoietic apoptosis ex vivo. Proc. Natl. Acad. Sci. USA 91, 7907-7911. 

While these functions can be a carried out by a single transporter isoform (e.g., the serotonin transporter, SERT) they may be split into separate processes carried out by distinct transporter subtypes, or in the case of acetylcholine, by a degrading enzyme. Termination of cholinergic neurotransmission is due to acetylcholinesterase which hydrolyses the ester bond to release choline and acetic acid. Reuptake of choline into the nerve cell is afforded by a high affinity transporter (CHT of the SLC5 gene family). 

Arpagaus, M., Fedon, Y., Cousin, X., Chatonnet, A., Berge, J.-B., Fournier, D. and Toutant, J.-P. (1994) cDNA sequence, gene structure, and in wire expression of ace-1, the gene encoding acetylcholinesterase of class A in the nematode Caenorhabditis elegans. Journal of Biological Chemistry 269, 9957-9965. 

Xie, W., Stribley, J., Chatonnet, A. et al. Postnatal development delay and supersensitivity to organophosphate in gene targeted mice lacking acetylcholinesterase. /. Pharmacol. Exp. Then 293 896-902, 2000. 

Lapidot-Iifson Y, et al. Coamplification of human acetylcholinesterase and butyrylcholinesterase genes in blood cells correlation with various leukemias and abnormal megakaryocytopoiesis. Proc. Natl. Acad. Sci. USA, 1989, 86(12), 4715-4719. 

Choi, R.C., Yung, L.Y., Dong, T.T., Wan, D.C., Wong, Y.H., Tsim, K.W. (1998). The calcitonin gene-related peptide-induced acetylcholinesterase synthesis in cultured chick myotuhes is mediated hy cyclic AMP. J. Neurochem. 71 152-60. 

Andres, C., Beeri, R., Friedman, A., Lev-Lehman, E., Henis, S., Timherg, R., Shani, M., Soreq, H. (1997). Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Iheta gene expression followed by late-onset neuromotor deterioration. Proc. Natl Acad. Sci. USA 94 8173-8. 

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