Pradrenergic receptors

Ritodrine has an effect on beta (p)2-adrenergic receptors, principally those that innervate the uterus. Stimulation of these p2-adrenergic receptors inhibits uterine smooth muscle contractions. The pradrenergic receptors are located in the heart and are not stimulated by ritodrine when administered as prescribed. Ritodrine is used to... 

The paradigm used by Ahlquist for classifying receptors based on their pharmacological characteristics (i.e., rank order of potency of agonists) was further developed by Lands and colleagues with the subdivision of the P-adrenergic receptors into pr and P2-subtypes (12). The pradrenergic receptor, the dominant receptor in heart and adipose tissue, was equally sensitive to epinephrine and... 

Lattion AL, Abuin L, Nenniger-Tosato M, Cotecchia S. Constitutively active mutants of the pradrenergic receptor. FEBS Lett 1999 457 302-306. 

Lin F, Wang H, Malbon CC. Gravin-mediated formation of signaling complexes in pradrenergic receptor desensitization and resensitization. J Biol Chem 2000 275 19,025-19,034. 

Xu J, Paquet M, Lau AG, Wood JD, Ross CA, Hall RA. prAdrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95. J Biol Chem 2001 276 41,310-41,317. 

Fan G, Shumay E, Malbon CC, Wang H. c-Src tyrosine kinase binds the Pradrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization. J Biol Chem 2001 276 13,240-13,247. 

Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ. G protein-coupled receptor kinase 5 regulates pradrenergic receptor association with PSD-95. J Biol Chem 2002 277 1607-1613. 

Hu LA, Tang Y, Miller WE, et al. Pj-Adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of pradrenergic receptor interaction with IV-methyl-D-aspartate receptors. J Biol Chem 2000 275 38,659-38,666. 

Bisognano JD, Weinberger HD, Bohlmeyer TJ, et al. Myocardial-directed overexpression of the human pradrenergic receptor in transgenic mice. J Mol Cell Cardiol 2000 32 817-830. 

Engelhardt S, Hein L, Wiesmann F, Lohse MJ. Progressive hypertrophy and heart failure in pradrenergic receptor transgenic mice. Proc Natl Acad Sci USA 1999 96 7059-7064. 

Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of pradrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation 2000 101 682-688. 

Perez JM, Rathz DA, Petrashevskaya NN, et al. prAdrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nat Med 2003 9 1300-1305. 

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