Oncogene expression

HU G, HAN c and chen j (1995) Inhibition of oncogene expression by green tea and (-)-epigallocatechin gallate in mice Nutrition and Cancer 24, 203-9. 

LIN J K, CHEN Y c, HUANG Y T and LiN-SHiAU s Y (1997) Snppression of protein kinase C and nuclear oncogene expression as possible molecnlar mechanisms of cancer chemoprevention by apigenin and curciunin Journal Cell Biochemistry Suppl. 28-9, 39-48. 

RAO G N and berk b c (1992) Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression Circulation Research 70, 593-9. 

LIN J K s, LEE F, HUANG Y T, LiN-SHiAU s Y (1995) Signal transduction and oncogene expression mediated by reactive oxygen species. In Proceedings of the International Symposium on Natural Antioxidants - Molecular Mechanisms and Health Effects. Eds Packer, L, Traber, M G, Xin, W Champaign, I L, USA AOCS Press, 303-19. 

Basset-S6guin, N., Escot, C., Blanchard, J.M., Kerai, C., Verrier, B., Moin, H. and Guilhou, J.J. (1990). High levels of c-fos proto-oncogene expression in normal human adult skin. J. Invest. Dermatol. 94, 418-422. 

Mutter, G. L and Wolgemuth, D. J. (1987). Distinct developmental patterns of c-mos proto-oncogene expression in female and male mouse germ cells. Proc. Nad. Acad. Sci. USA 88 7869-7872. 

Sanchez, J-C., Wirth, P., Jaccoud, S., Appel, R.D., Sarto, C.Wilkins, M.R., Hochstrasser, D.F. (1997). Simultaneous analysis of cyclin and oncogene expression using multiple monoclonal antibody immunoblots. Electrophoresis 18, 638. 

Neckers, L., Whitesel, L., Rosolen, A., and Geselowitz, D.A., Antisense inhibition of oncogene expression, Critical Reviews in Oncogenesis, 1992, 3, 175-231. 

Bakkus, M.H., Brakel-van Peer, K.M., Adriaansem, H.J., Wierenga-Wolf, A.F., van den Akker, T.W., Dicke-Evingep M.J., and Benner, R. (1989) Detection of oncogene expression by fluorescent in situ hybridization in combination with immunofluorescent staining of cell surface markers. Oncogene 4,1255-1262. 

Gribaldo, L., M.G. Sacco, S. Casati, I. Zucchi, M.K. Dosanjh, P. Catalani, and E. Marafante. 1998. Modulation of proto-oncogene expression by polychlorinated biphenyls in 3T3-L1 cell line. Jour. Toxicol. Environ. Health 55A 121-131. 

Finzer P, Ventz R, Kuntzen C, Seibert N, Soto U, Rosl F. (2002) Growth arrest of HPV-positive cells after histone deacetylase inhibition is independent of E6/E7 oncogene expression. Virology 304 265-273. 

At-MNDP 31-33, 36, 108), whose mechanism of intracellular localization is related to the presence of oncogenically expressed tumor-membrane alkaline phosphatase isoenzymes 42, 108), has been demonstrated strikingly effective in an animal tumor model 33, 34, 38, 39). It has also served as a concomitant analytical probe for identifying the intracellular locus of radiotherapeutic action of this class of drug by a-particle track autoradiography 33,106-109). Phase I and II human therapeutic trials are shortly envisaged 33, 34). 

This study reports that retrovirus vector insertion into a proto-oncogene activates proto-oncogene expression, which may trigger malignancy. 

Richmond, R.E., DeAngelo, A.B. Daniel. F.B. (1992) Immunohistochemical detection of ras and myc oncogene expression in regenerating rat liver. Toxicol. Lett., 60, 119-129... 

The mechanisms by which antitumor-promoters suppress the tumor promotion are not known, but may be due to the following effects (i) inhibition of polyamine metabolism (ii) inhibition of arachidonic acid metabolism (iii) protease inhibition (iv) induction of differentiation (v) inhibition of oncogene expression (vi) inhibition of PKC and (vii) inhibition of oxidative DNA damage [3,6,91]. The polyamine content of cells is correlated to their proliferative, and often, their neoplastic capabilities. A key enzyme in the polyamine biosynthetic pathway, ornithine decarboxylase (ODC), catalyzes the convertion of ornithine to putrescine. Phorbol ester promoters such as TPA cause increased ODC activity and accumulation of polyamines in affected tissues. Diacylglycerol activated PKC, and the potent tumor promoter, TPA, binds to, and activates PKC, in competition with diacylglycerol. PKC stimulation results in phosphorylation of regulatory proteins that affect cell proliferation. Some chemopreventive agents have inhibitory activity towards PKC. Refer to recent review articles for further discussion [3,6,91]. 

Dati, C., Antoniotti, S., Tavema, D., Perroteau, I., and Bartoli, M. 1990. Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells. Oncogene 5 1001-1006. 

Press, M. F., Hung, G., Godolphin, W., and Slamon, D. J. 1994. Sensitivity of HER-2/neu antibodies in archival tissue samples Potential source of error in immunohistochemical studies of oncogene expression. Cancer Res. 54 2771-2777. 

Landers, J.E., Cassel, S.L. and George, D.L. (1997) Translational enhancement of MDM2 oncogene expression in human tumor cells containing a stablized wild-type p53 protein. Cancer Res., 57, 3562-3568. 

Fung H, Quinlan TR, Janssen YMW, et al. 1997b. Inhibition of protein kinase C prevents asbestos-induced c-fos and c-jun proto-oncogene expression in mesothelial cells. Cancer Res 57 3101-3105. 

Hall AP, hvine J, Blyth K, Cameron ER, Onions DE, Campbell ME (1998) Tumours derived horn HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. J Pathol 186 209—214. 

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