Anti-inflammatory antioxidants

Epidemiological studies and intervention trials with food and beverages rich in flavonoids are not conclusive although flavonoids were recognized to display numerous antioxidant, anti-inflammatory, anti-tumoral, and anti-microbial activities. The antioxidant capacity of flavonoids has been largely reported in numerous in vitro and ex vivo systems. Numerous reviews "" have been published on the antioxidant properties of flavonoids. Degenerative diseases are largely associated with oxidative mechanisms that may be counteracted by flavonoids. 

Resveratrol is another type of polyphenol, a stilbene derivative, that has assumed greater relevance in recent years as a constituent of grapes and wine, as well as other food products, with antioxidant, anti-inflammatory, anti-platelet, and cancer preventative properties. Coupled with the cardiovascular benefits of moderate amounts of alcohol, and the beneficial antioxidant effects of flavonoids, red wine has now emerged as an unlikely but most acceptable medicinal agent. 

In light of the antioxidant, anti-inflammatory, and antiamyloid effects, curcumin has become a candidate compound for the prevention or treatment of AD [Calabrese et al., 2007]. Treatment of astrocytes with curcumin induced the cytoprotective proteins HO-1, NAD(P)H quinone oxidoreductase 1 (NQOl), and glutathione transferase (GST) and provided protection against... 

Anti-inflammatory, antimutagenic, antioxidant Anti-inflammatory, antitumor, cholesterol-lowering activity Anti-inflammatory, cancer preventive... 

ABSTRACT More than 200 naturally occurring oligostilbenes isolated from plant kingdom are grouped into I-V structural types. They are a special kind of polyphenolic natural products with multi-faceted bioactivities. This article will review their classification, distribution, spectral characteristics, biological activities (anti-fungal, antibacterial, antioxidant, anti-inflammatory and anticarcinogenic activities, etc.) and mimetic biosynthesis. 

The pharmacological assays and activities of natural phenylpropanoid glycosides, extracted from a variety of plants are summarized in this review, such as antioxidant, anti-inflammatory, healing, antimicrobial and antitumoral-chemopreventive. Structure-activity relationships are also discussed. 

Tropical Zingiberaceae plants possessing new anti-inflammatory antioxidants anti-inflammatory activity of isolated aniioxidanl, 225,226r Curcuma domestica, 220,222-223/ Curcuma xanthorMza, 220,223/ Zingiber cossumar, 220,224/... 

Abstract In the current presentation, our latest results performed on Lycopodium clavatum L. the most common species in Turkey, are given in terms of biological activity, which include antibacterial, antifungal, antiviral, cytotoxic, antioxidant, anti-inflammatory and immunomodulatory activities of this fern. Antioxidant activity of the plant was assessed on the basis of the radical scavenging effect of the stable... 

Like pleiotropic effects of statins, DHA also produces antiexcitotoxic, antioxidant, anti-inflammatory effects through the generation of its hpid mediators (Table 3.4) (Simopoulos, 2006 Farooqui et al., 2008 Farooqui, 2009b). These lipid mediators include resolvins and neuroprotectins. These metabohtes are very important from stroke therapeutic point of view. They antagonize the effects of... 

Caffeine provides the short-term benefits of increasing speed and accuracy of the cognitive processes, as well as enhancing a sense of well-being. Recent data also point to antioxidant, anti-inflammatory, and anti-amyloid activities of caffeine in the brain. (Coffee and tea, especially green tea, also contain other compounds besides caffeine that can contribute to health in a variety of ways.)... 

More complex shikimate derivatives have also been produced. One example is the antioxidant, anti-inflammatory, and antiproliferative hydroxycinnamoyl anthranilates (also known as avenanthramides or Avns). The production was first shown from feeding of cinnamates and anthranilates, but the entire pathway from glucose was also demonstrated by using feedback-resistant AroG and TyrA as well as exogenous 4-coumarate CoA ligase from Arabidopsis thcdiana and hydroxycinnamoyl/benzoyl-CoA/anthranilate Af-hydroxycinnamoyl/ benzoyltransferase from Dianthus caryophyllus (carnation) [43]. 

More than 60 ginsenosides have been isolated from different parts of American ginseng, Panax quinquefolius, most of them also exhibiting a four-trans-ring rigid steroid skeleton. Antioxidant, anti-inflammatory, and immunostimulatory activities of ginseng seem to explain their neuroprotective, cardioprotective, antidiabetic, antioxidant, and anticancer properties [186]. 

The active stilbene agents, reported in this chapter, derived from either marine or terrestrial sources tested in clinics have a unique chemistry that offers valuable information for their use as compounds for further chemical synthesis of more potent chemotherapeutic drugs against a variety of cancers. The stilbenes also possess the antioxidative, anti-inflammatory, and estrogenic effects and chemo-preventive activities. A challenging goal is the search for more active natural products as therapeutic agents in cancer and other diseases. This search should be continued until a novel and very effective compound is found. 

Many food proteins were found to possess biological activities beyond basic nutritional values. The peptides generated from certain food proteins may possess strong biological activities such as antioxidant, anti-inflammatory, antihypertensive, antimicrobial, immunomodulatory, and opioid properties (Bennett et al., 2005 Ferreira et al., 2007 FitzGerald et al., 2004 Gauthier et al., 2006 Gobbetti et al., 2004 Yamamoto et al., 2003). 

Resveratol is an antioxidant, anti-inflammatory, antiplatelet and antiallergy agent with demonstrated cancer-preventative activity (Cheong et al. 1999 Steele et al. 1998). It has been shown to inhibit cycloxygenase-2 (COX-2) in vitro (Subbaramaiah et al. 1998). 

---