Antigen, 3, 306 defined

Gerdes, J., Lemke, H, Baisch, H, Wacker, H -H, Schwab, U, and Stem, H. (1984) Cell-cycle analysis of a proliferation-associated human nuclear antigen defined by the MAb Ki-67. J Immunol 133, 1710-1715... 

Eissenberg, J.C., Ayyagari, R., Gomes, X.V. and Burgers, P.M. (1997) Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase and DNA polymerase. Mol. Cell. Biol., 17, 6367-6378. 

Durbin H, Young S, Stewart LM, Wrba F, Rowan AJ, Snary D, et al. An epitope on carcinoembryonic antigen defined by the clinically relevant antibody PR1A3. Proc Natl Acad Sci USA 1994 91(10) 4313-4317. 

The CDS antigen defines the suppressor/cytotoxic T-cell subset. It is expressed in concert with CD4 in thymocytes, but this state persists in only a small population of circulating cells. CD4/CD8 ratios are not analogous to immunoglobulin light chain ratios in B-cell malignancies infectious and inflammatory conditions can markedly skew the normal 2 1 ratio. The beta chain of CDS detected in fixed tissue has nearly the sensitivity of flow cytometry. 

Sheibani K, Nathwani BN, Winberg CD, et al. Antigenically defined subgroups of lymphoblastic lymphoma. Relationship to clinical presentation and biologic behavior. Cancer. 1987 60(2) 183-190. 

Tanimoto M, Scheinberg DA, Cordon-Cardo C, Huie D, Clarkson BD, Old LJ. Restricted expression of an early myeloid and monocytic cell surface antigen defined by monoclonal antibody M195. Leukemia 1989 3 339-348. 

The HLA-DR series of serological specificities was defined at the Seventh International Histocompatibility Workshop (B16) following the finding that human serum contains antibodies that react with B cells rather than T cells (V3). The serological reaction patterns of these antibodies correlated well with the HLA-D specificities detected in the MLC test and the antigens defined in this way were designated HLA-DR (where the DR stands for D-Related ). A total of 24 HLA-DR specificities are currently recognized by the WHO Nomenclature Committee (Table 1) (B17). 

Bourdon, M.A., Wikstrand, D.J., Furthmayr, H., Matthews, T.J. and Bigner, D.D. (1983) Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. Cancer Res. 43 2796-2805. 

Civin C 1, Strauss L C, Brovall C (1984). Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-la cells. J. Immunol. 133 157-165. 

The definition of an association constant for an antibody—antigen reaction can become more complex if the antibody—antigen reaction iavolves a multivalent antigen, as is the case when a polyclonal antisemm is used for detection of an antigen. This type of multivalent binding is termed avidity and is defined by the equation ... 

LDH-x is one of the best characterized antigens and its amino acid sequence is known. A synthetic peptide based on a portion of the molecule has been shown to reduce fertUity in laboratory animals. The nucleotide sequence coding for human LDH-x has been defined and engineered into an expression vector system (121). 

The normal immune response is modeled using antibodies A, B cells, helpers H, suppressors S and antigens, or viruses, V. Each of these concentrations can be either high (= 1) or low 0). The dynamics is defined as follows ... 

CD lb Known to be present on thymocytes and dendritic cells CDlc Isoform c also known as non-classical MHC class I-like surface antigen present on thymocytes CD2 Defines T cells involved in antigen non-specific cell activation CD3 Also known as T cell receptor-associated surface glycoprotein on T cells CD4 Defines MHC class Il-restricted T cell subsets... 

CDS Defines MHC class I-restricted T cell subset present on NK cells CDIO Known to be common acute leukaemia antigen CDlla Known to be zn a chain of LFA-1 (leucocyte function antigen-1) present on several types of leucocyte and which mediates adhesion CDllc Known to be z complement receptor 4 a chain. 

The role of antigens derived from dietary intake in the development of IBD is less well defined. There is some speculation that ingestion of large quantities of refined carbohydrates or margarine leads to higher rates of CD. Use of oral contraceptives has been associated with increased development of IBD in some cohort studies, but a strong causal relationship has not been proven.7... 

Prostate-specific antigen (PSA) is a useful marker for detecting prostate cancer at early stages, predicting outcome for localized disease, defining disease-free status, and monitoring response to... 

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